Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis

Liang, Xiaoyu; Li, Huiyang; Li, Xuanling; Tian, Xinxin; Zhang, Aiai; Luo, Qiong; Duan, Jianwei; Chen, Youlu; Pang, Liyun; Li, Chen; Liang, Xing‐Jie; Zeng, Yong; Yang, Jing

doi:10.1016/j.apsb.2022.04.002

Cited by 19 publications

(15 citation statements)

References 59 publications

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“…NPs also enhanced RAP release in response to CTSK stimulation in vitro, significantly inhibiting OxLDL phagocytosis and cytokine release by pro-inflammatory macrophages. These results show that the strategy based on enzyme-sensitivity could [131] Copyright 2022, Elsevier Ltd. B) The therapeutic mechanism of HA-CeO 2 NPs. Reproduced with permission.…”

Section: Enzyme-responsive Strategiesmentioning

confidence: 79%

“…designed a new H 2 O 2 ‐scavenging polymer, polylactic glycolic acid‐diphenyl ring‐peroxyoxalate bond‐polyethylene glycol. [ 131 ] The conjugation of the diphenyl ring with the peroxyoxalate bond increased the sensitivity to hydrogen peroxide; the desired reaction could be obtained at 10 µmol L −1 , which is close to the lowest concentration of H 2 O 2 in the pathological environment. At the same time, a H 2 O 2 ‐scavenging nano‐bionic system decreased ROS to normal levels in lipopolysaccharide‐stimulated RAW and endothelial cells in vitro.…”

Section: Therapeutic Strategies For Asmentioning

confidence: 99%

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Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Xiao,

Li,

Xiong

et al. 2023

Advanced Science

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Atherosclerosis, the leading cause of death worldwide, is responsible for ≈17.6 million deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery efficiencies and significant side effects, and this has hampered the development of effective treatment strategies. Diversified nanomaterials can improve drug properties and are considered to be key for the development of improved treatment strategies for atherosclerosis. The pathological mechanisms underlying atherosclerosis is summarized, rationally designed nanoparticle‐mediated therapeutic strategies, and potential future therapeutic targets for nanodelivery. The content of this study reveals the potential and challenges of nanoparticle use for the treatment of atherosclerosis and highlights new effective design ideas.

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Section: Enzyme-responsive Strategiesmentioning

confidence: 79%

Section: Therapeutic Strategies For Asmentioning

confidence: 99%

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Xiao,

Li,

Xiong

et al. 2023

Advanced Science

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“…Of course, the exponential conversion of doses between animals and humans using body surface area (0.67) is not the gold standard, and estimates always require the careful consideration of differences in pharmacokinetics and pharmacodynamics between species. In addition, research on the combination of nanotechnology and drugs in recent years can improve bioavailability and markedly reduce the drug dose, which is also worthy of further exploration in the future (Liang et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

Icariin alleviates ferroptosis‐related atherosclerosis by promoting autophagy in xo‐LDL‐induced vascular endothelial cell injury and atherosclerotic mice

Wang

Meng

Mao

et al. 2023

Phytotherapy Research

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Vascular endothelial cells (VECs) are located between the blood plasma and the vascular tissue, and the ferroptosis (iron‐dependent programmed cell death) of VECs can lead to a range of cardiovascular diseases. Icariin is the main active ingredient of Epimedium brevicornum Maxim., which can improve endothelial cell dysfunction. In the present study, the protective effects of icariin on oxidised low‐density lipoprotein (ox‐LDL)‐treated VECs and high‐fat diet‐fed Apolipoprotein E‐deficient mice were investigated. Inflammatory fibrosis in tissues and inflammatory factors in serum and cell supernatants were detected, and mitochondrial membrane potential and the expression levels of ferroptosis‐associated proteins were also detected. The results revealed that icariin reduced the endothelial atherosclerotic plaque area and collagen fibres in aortic sinus tissue, and increased the viability and mitochondrial membrane potential, whereas it reduced the reactive oxygen species levels of VECs. The nucleation of transcription factor EB (TFEB) and subsequent autophagy were negatively associated with ferroptosis in endothelial cells, and the more prominent the autophagy, the lower the levels of ferroptosis. Furthermore, by co‐treating the cells with icariin and the two autophagy inhibitors, Bafilomycin A1 (blocking autophagosome and lysosome fusion) and 3‐methyladenine (blocking autophagosome formation), respectively, the promoting effects of icariin on autophagy were found to be mediated through the process of autophagosome–lysosome fusion. In in vivo experiments, icariin reduced ferroptosis, alleviated atherosclerotic lesions and increased the rate of TFEB nucleation. Additionally, it was found that ARG304, THR308 and GLN311 were the optimal binding sites for the interaction between icariin and TFEB. Taken together, these results suggest that the fusion of autophagosomes and lysosomes promoted by icarrin enhances autophagy and thus reduces ferroptosis. Therefore, icariin may be a potential candidate for the prevention of ferroptosis of VECs and, thus, for the treatment of cardiovascular diseases.

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Section: Biomedical Biosensing and Bioimagingmentioning

confidence: 99%

“…For example, unbalanced human concentrations of H 2 O 2 are related to myocardial infarction, alzheimer's disease, and atherosclerosis, which can be used as potential biomarkers for many diseases, as well as intermediate biomolecules in analytical measurements. [189][190][191] Therefore, the development of H 2 O 2 biosensors with micromolar detection limits (LODs) based on time-sensitivity, sensoramplification, and precision-improvement is highly needed but not yet realized completely. An iron-hemin based MOF loaded on chitosan reduced graphene oxide (GO) was used for realtime monitoring of H 2 O 2 released by living cells (Fig.…”

Section: Biosensingmentioning

confidence: 99%

Tunable metal–organic frameworks assist in catalyzing DNAzymes with amplification platforms for biomedical applications

Zhu,

Xu,

Ling

et al. 2023

Chem. Soc. Rev.

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Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis

Cited by 19 publications

References 59 publications

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Recent Advances in Anti‐Atherosclerosis and Potential Therapeutic Targets for Nanomaterial‐Derived Drug Formulations

Icariin alleviates ferroptosis‐related atherosclerosis by promoting autophagy in xo‐LDL‐induced vascular endothelial cell injury and atherosclerotic mice

Tunable metal–organic frameworks assist in catalyzing DNAzymes with amplification platforms for biomedical applications

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