Highly sensitive label-free liquid crystal-based aptasensor to detect alpha-fetoprotein

Duong, Duong Song Thai; Jang, Chang‐Hyun

doi:10.1080/02678292.2021.2005165

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Liquid crystal (LC) sensors achieve target detection by transducing and amplifying chemical and biological events into visible optical signals. In the LC sensor by Duong and Jang (2021) , the aptamer was immobilized on the surface of substrates, and then the binding of the AFP to its aptamer disrupted the LC alignment to generate the detection signal. The quantification limit of AFP achieved was 12.62 pg/mL ( Duong and Jang, 2021 ).…”

Section: Optical Aptasensorsmentioning

confidence: 99%

“…In the LC sensor by Duong and Jang (2021) , the aptamer was immobilized on the surface of substrates, and then the binding of the AFP to its aptamer disrupted the LC alignment to generate the detection signal. The quantification limit of AFP achieved was 12.62 pg/mL ( Duong and Jang, 2021 ). Qi et al (2020) designed a platform where the two aptamers for AFP captured targets synergistically to format sandwich complexes of apt1/protein/apt2, which induced the release of signal DNA into the aqueous solution (Qi et al, 2020a).…”

Section: Optical Aptasensorsmentioning

confidence: 99%

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Recent advances in optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of hepatocellular carcinoma

Dong

Wang

Yuan

et al. 2023

Front. Cell Dev. Biol.

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Hepatocellular carcinoma (HCC) accounts for approximately 90% of all primary liver cancers and is one of the main malignant tumor types globally. It is essential to develop rapid, ultrasensitive, and accurate strategies for the diagnosis and surveillance of HCC. In recent years, aptasensors have attracted particular attention owing to their high sensitivity, excellent selectivity, and low production costs. Optical analysis, as a potential analytical tool, offers the advantages of a wide range of targets, rapid response, and simple instrumentation. In this review, recent progress in several types of optical aptasensors for biomarkers in early diagnosis and prognosis monitoring of HCC is summarized. Furthermore, we evaluate the strengths and limitations of these sensors and discuss the challenges and future perspectives for their use in HCC diagnosis and surveillance.

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Section: Optical Aptasensorsmentioning

confidence: 99%