Highly sensitive microcantilever biosensors with enhanced sensitivity for detection of human papilloma virus infection

Kim, Hyung Hoon; Jeon, Hae Jeong; Cho, Hyun Kook; Cheong, Jea Hun; Moon, Hyeong-Soon; Go, Jeung Sang

doi:10.1016/j.snb.2015.08.014

Cited by 33 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These studies fall into two categories in terms of the operation mode: dynamic mode and static mode. Nanomechanical sensors operated in dynamic mode detect viruses by their mass (more specifically, shifts in the resonant frequency; Johnson et al, 2006 ; Braun et al, 2009 ; Cha et al, 2009 ; Capobianco et al, 2010 ) while static mode operates based on the stress or strain (Gunter et al, 2003 ; Sreepriya and Hai-Feng, 2006 ; Alodhayb et al, 2013 ; Xu et al, 2014 ; Gorelkin et al, 2015 ; Kim et al, 2015 ). Thus, the FEA simulation in the present study can be adapted to the detection of viruses in static mode.…”

Section: Discussionmentioning

confidence: 99%

Finite Element Analysis on Nanomechanical Detection of Small Particles: Toward Virus Detection

2016

View full text Add to dashboard Cite

Detection of small particles, including viruses and particulate matter (PM), has been attracting much attention in light of increasing need for environmental monitoring. Owing to their high versatility, a nanomechanical sensor is one of the most promising sensors which can be adapted to various monitoring systems. In this study, we present an optimization strategy to efficiently detect small particles with nanomechanical sensors. Adsorption of particles on the receptor layer of nanomechanical sensors and the resultant signal are analyzed using finite element analysis (FEA). We investigate the effect of structural parameters (e.g., adsorption position and embedded depth of a particle and thickness of the receptor layer) and elastic properties of the receptor layer (e.g., Young's modulus and Poisson's ratio) on the sensitivity. It is found that a membrane-type surface stress sensors (MSS) has the potential for robust detection of small particles.

show abstract

Section: Discussionmentioning

confidence: 99%

Finite Element Analysis on Nanomechanical Detection of Small Particles: Toward Virus Detection

2016

View full text Add to dashboard Cite

show abstract

“…For instance, Kim et al [13] developed a microcantilever-based biosensor for the electrical detection of HPV by its conjugation with specific proteins and magnetic beads. Similarly, Huang et al [14] implemented electrical impedance spectroscopy (EIS) and differential pulse voltammetry on graphene/gold electrodes to detect specific DNA strands of HPV.…”

Section: Case Of Study: Hpvmentioning

confidence: 99%

Detection of Pathogens Using Microfluidics and Biosensors

Lopez‐Barbosa¹,

Campaña²,

JulianaNoguera³

et al. 2018

Biosensing Technologies for the Detection of Pathogens - A Prospective Way for Rapid Analysis

View full text Add to dashboard Cite

Point-of-care devices technology are a promising way towards the recognition of pathogens in early-stage diagnosis, which is critical for the success of inexpensive treatments as opposed to the high costs of managing the disease. The integration of immunoassays with read out circuitry allows the implementation of diagnostic devices for their use by untrained personnel, without compromising reliability. In the following chapter, three different biosensors based on lab-on-a-chip (LoC) and microfluidic technologies were designed, assembled and tested for pathogen diagnosis. The devices allowed the effective detection of the human papilloma virus, Mycobacterium tuberculosis and Chagas parasite in shorter times and with smaller sample volumes than those required by current clinical diagnosis techniques. All devices were benchmarked against commercial techniques in terms of cost and time requirement per test.

show abstract

“…Kim et al (2015) introduced a piezoresistive microcantilever integrated with magnetic nanobeads for the detection of HPV genotype. The magnetic force in the cross-sectional direction compelled the magnetic beads associated with the biocomplex to deflect and sense [ 20 ]. Similarly, Wee et al (2005) developed a novel electrical detection of prostate-specific antigens and C-reactive proteins using piezoresistive self-sensing micro-cantilevers.…”

Section: Introductionmentioning

confidence: 99%

Piezoelectric point-of-care biosensor for the detection of SARS-COV-2 (COVID-19) antibodies

Mandal

Indaleeb

Younan

et al. 2022

Sensing and Bio-Sensing Research

View full text Add to dashboard Cite

Highly sensitive microcantilever biosensors with enhanced sensitivity for detection of human papilloma virus infection

Cited by 33 publications

References 29 publications

Finite Element Analysis on Nanomechanical Detection of Small Particles: Toward Virus Detection

Finite Element Analysis on Nanomechanical Detection of Small Particles: Toward Virus Detection

Detection of Pathogens Using Microfluidics and Biosensors

Piezoelectric point-of-care biosensor for the detection of SARS-COV-2 (COVID-19) antibodies

Contact Info

Product

Resources

About