Highly sensitive/selective 3D nanostructured immunoparticle-based interface on a multichannel sensor array for detecting amyloid-beta in Alzheimer's disease

Liu, Ta Chung; Lee, Yi Chao; Ko, Chiung Yuan; Liu, Ru‐Shi; Ke, Chien-Chih; Lo, Yu Chun; Hong, Pei Sung; Chu, Chao; Chang, Ching Wen; Wu, Pu Wei; Chen, San Yuan

doi:10.7150/thno.25625

Cited by 29 publications

(18 citation statements)

References 37 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One day after the final treatment (at day 28), mice were injected intravenously with 0.282 mCi [ 18 F]‐fluorodeoxyglucose ( 18 F‐FDG). Images were acquired using a LabPET/X‐SPECT/X‐O CT imaging system (TriFoil Imaging, Inc., USA) at 30 min after injection of 18 F‐FDG . In addition, CT acquisitions were conducted for 3 min (FOV = 80 mm) after each PET scan to detect anatomical information for each animal and construct an attenuation map for further image restoration.…”

Section: Methodsmentioning

confidence: 99%

pH‐Responsive PEG‐Shedding and Targeting Peptide‐Modified Nanoparticles for Dual‐Delivery of Irinotecan and microRNA to Enhance Tumor‐Specific Therapy

Juang¹,

Chang²,

Wang³

et al. 2019

Small

124

View full text Add to dashboard Cite

Irinotecan is one of the main chemotherapeutic agents for colorectal cancer (CRC). MicroRNA‐200 (miR‐200) has been reported to inhibit metastasis in cancer cells. Herein, pH‐sensitive and peptide‐modified liposomes and solid lipid nanoparticles (SLN) are designed for encapsulation of irinotecan and miR‐200, respectively. These peptides include one cell‐penetrating peptide, one ligand targeted to tumor neovasculature undergoing angiogenesis, and one mitochondria‐targeting peptide. The peptide‐modified nanoparticles are further coated with a pH‐sensitive PEG‐lipid derivative with an imine bond. These specially‐designed nanoparticles exhibit pH‐responsive release, internalization, and intracellular distribution in acidic pH of colon cancer HCT116 cells. These nanoparticles display low toxicity to blood and noncancerous intestinal cells. Delivery of miR‐200 by SLN further increases the cytotoxicity of irinotecan‐loaded liposomes against CRC cells by triggering apoptosis and suppressing RAS/β‐catenin/ZEB/multiple drug resistance (MDR) pathways. Using CRC‐bearing mice, the in vivo results further indicate that irinotecan and miR‐200 in pH‐responsive targeting nanoparticles exhibit positive therapeutic outcomes by inhibiting colorectal tumor growth and reducing systemic toxicity. Overall, successful delivery of miR and chemotherapy by multifunctional nanoparticles may modulate β‐catenin/MDR/apoptosis/metastasis signaling pathways and induce programmed cancer cell death. Thus, these pH‐responsive targeting nanoparticles may provide a potential regimen for effective treatment of colorectal cancer.

show abstract

Section: Methodsmentioning

confidence: 99%

pH‐Responsive PEG‐Shedding and Targeting Peptide‐Modified Nanoparticles for Dual‐Delivery of Irinotecan and microRNA to Enhance Tumor‐Specific Therapy

Juang¹,

Chang²,

Wang³

et al. 2019

Small

124

View full text Add to dashboard Cite

show abstract

“…Similar concept of electrochemical application was extended using silk broin material by Liu et al on the development of POC device for Ab detection based on blood sample. 226 In addition, a thorough discussion on state-of-the-art of microelectrode-based in vivo neurochemicals sensing has been discussed in a review by Xu et al 227 A microelectrode principle was further employed by Peng et al using carbon bre to monitor the superoxide anion radical (O 2 c À ) which directly correlate with production of reactive oxygen species-induced Ab. 224 They engineered ionic-liquid polymer with carbon nanotubes to mask the immobilized oxide dismutase (i.e., catalysing O 2 c À into peroxide species) from the enzyme leakage thereby, achieving better sensitivity (Fig.…”

Section: Current In Vivo Strategies Of Biosensors For Admentioning

confidence: 99%

Clinically oriented Alzheimer's biosensors: expanding the horizons towards point-of-care diagnostics and beyond

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Chemical sensors target analytes such as chemical compounds found in urine (Wong et al, 2020), blood (Liu, Lee, et al, 2018) and human serum (Yang et al, 2017). These body fluids contain biomarkers, drugs and metabolites that can give valuable information about human health.…”

Section: Elec Tro Chemic Al Ba S Ed S Ensormentioning

confidence: 99%

Conducting polymers in wearable devices

et al. 2020

View full text Add to dashboard Cite

The increase interests in wearable device market are triggered by healthcare monitoring. Common examples are pulse, heart rate and temperature monitors. Wearable technology has opened up new path for non-invasive diagnostic and therapeutic technologies via sensing of biomarker/drug from the liquid extracted on skin including sweat (Bandodkar & Wang, 2014; Liu et al., 2017). The increasing demand of integrating electronic technology in wearable devices is driven by needs for individual monitoring remotely at home, often called as ubiquitous health care (Choudhuri et al., 2019). In addition, wearable devices allow continuous, long time monitoring at any place, anytime (Bohr et al., 2019). Mechanical and electrical responsive conducting polymers (CPs), plus high flexibility and stretch-ability contribute to recent accelerate growth of publications involving conducting polymer in wearable and skin-attachable device. Metals and silica (semiconductors) are inorganic materials that are generally regarded as highly conductive but are rigid and inflexible. The concept of organic conductors/semiconductors has arisen since the discovery of highly conducting polyacetylene by Hideki Shirakawa, working along with Alan MacDiarmid and physicist Alan Heeger in 1977 (Shirakawa et al., 1977). The most apparent advantage of organic electronics as compared to inorganic is that they are highly flexibility and they are lightweight. These properties are ideal for wearable sensors. Conducting polymers with long-term electrical and chemical stability such as polypyrrole (PPy), poly(3,4-ethylenedioxy-thiophene) (PEDOT) and polyaniline (PANi) (Figure 1) have gained popularity in this field (Puiggali-Jou et al., 2019; Talikowska et al., 2019). Doping counterions in close proximity to the extended pi-bond significantly improve CP conductivity. These doped CPs have electrical conductivities ranging from >1 S/cm to >1000 S/cm aligning CPs with the inorganic semiconductors, for example silicon

show abstract

Highly sensitive/selective 3D nanostructured immunoparticle-based interface on a multichannel sensor array for detecting amyloid-beta in Alzheimer's disease

Cited by 29 publications

References 37 publications

pH‐Responsive PEG‐Shedding and Targeting Peptide‐Modified Nanoparticles for Dual‐Delivery of Irinotecan and microRNA to Enhance Tumor‐Specific Therapy

pH‐Responsive PEG‐Shedding and Targeting Peptide‐Modified Nanoparticles for Dual‐Delivery of Irinotecan and microRNA to Enhance Tumor‐Specific Therapy

Clinically oriented Alzheimer's biosensors: expanding the horizons towards point-of-care diagnostics and beyond

Conducting polymers in wearable devices

Contact Info

Product

Resources

About