Highly sensitive Surface Plasmon Resonance for Biosensor employing MXene and perovskite Heterostructure

Abstract

Cancer has become the most serious disease in the world, and achieving rapid and accurate detection has become the focus of research. In this paper, the novel surface plasmon resonance (SPR)-based biosensor cancer cells (Jurkat/PC12/HeLa) is presented. The biosensor is based on a hybrid structure of two-dimensional (2D) material with MXene (Ti3C2Tx) and perovskite (MAPbBr3). The Blood (Jurkat), Adrenal Glands (PC12), Cervical (HeLa) cancer cells through the multilayer Ag-ITO thin film caused by the change of reflectivity, so as to calculate the sensitivity and figure of merit (FOM) value. The simulation analysis shows that PC12 has the highest sensitivity in SPR biosensor. When the Ag, ITO and MAPbBr3 are 52 nm, 5 nm, and monolayer, the minimum sensitivity of SPR biosensor is 288.79 °/RIU and by PC12. Compared with the Ag film of traditional SPR biosensors, the PC12 sensitivity of the hybrid structure is increased by 1.89 times. In terms of disease diagnosis, the sensitivity and accuracy of SPR biosensors have been greatly improved, providing a basis for early diagnosis and treatment of diseases. In addition, SPR biosensor hardware provides theoretical support.