Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma

Roseboom, Ignace C.; Thijssen, Bram; Rosing, Hilde; Mbui, Jane; Beijnen, Jos H.; Dorlo, Thomas P. C.

doi:10.1016/j.jpba.2020.113245

Cited by 10 publications

(24 citation statements)

References 24 publications

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“…The detection wavelength was set at 254 nm, and the total run time was 15 min. The method validation of the bioanalytical assays for pharmacokinetic studies was performed according to the bioanalysis guidelines from the US FDA [34].…”

Section: Hplc Instrumentation and Methods Validationmentioning

confidence: 99%

Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone

Hsueh

Tsai²

2020

BMC Complement Med Ther

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Background: The prevalence and therapeutic effects of the use of herbal remedies for chronic liver diseases make the combined administration of herbal products with conventional treatment unable to be ignored. This study investigated the pharmacokinetic and pharmacodynamic herb-drug interactions between the herbal formula Yin-Chen-Hao-Tang (YCHT) and spironolactone. Methods: A selective high-performance liquid chromatography (HPLC) method was developed and validated for the detection of spironolactone and its metabolite canrenone in rat urine. The interaction study was conducted by collecting urine samples after oral administration of spironolactone alone or in combination with YCHT for 5 days. Urine pharmacokinetic parameters and urinary sodium, potassium, volume, and weight were analyzed. Results: The results revealed significant increases in the cumulative amount and the area under the rate curve (AURC) of the metabolite canrenone after pretreatment with the high dose of YCHT. The urine weight and volume were significantly reduced dose-dependently as a result of pretreatment with YCHT. The urinary sodium-topotassium ratio, which indicates diuretic effects, was also reduced in the high-dose YCHT condition. Conclusions: Herb-drug pharmacokinetic and pharmacodynamic interactions between YCHT and spironolactone were observed in the study. The herb-drug interaction that appeared with a single dose of spironolactone should be considered when patients are being treated with a continuous administration of this drug.

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Section: Hplc Instrumentation and Methods Validationmentioning

confidence: 99%

Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone

Hsueh

Tsai²

2020

BMC Complement Med Ther

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“…Sixty-seven (67) out of the 71 articles reported the use of HPLC in the bioanalysis of aminoglycosides, while four articles used ultra-performance liquid chromatography (UPLC) [35]. The relevant aspect of liquid chromatographic conditions used in the various articles, such as matrix, sample preparation, flow rate, column selection, mobile phase, and detection, have been summarized (Table 1 A d v a n c e d o n l i n e a r t i c l e…”

Section: Aminoglycosidesmentioning

confidence: 99%

“…Solvents that were used for PPT included acetonitrile for the extraction of netilmicin, amikacin, tobramycin, gentamicin, etimicin, neomycin, and isepamicin [6,15,21,23,32,[37][38][39][40]42,68,[73][74][75][76]78,79,82,86]; trichloroacetic acid for the extraction of geneticin, spectinomycin, tobramycin, gentamicin, kanamycin, hygromycin, apramycin, streptomycin, dihydrostreptomycin, amikacin, neomycin, and paromomycin [29,34,35,57,61,72,81]; methanol for the extraction of geneticin, amikacin, tobramycin, sisomicin, and netilmicin [29,41,48]; perchloric acid for the extraction of kanamycin, dibekacin, arbekacin, and streptomycin [26,33,49,51]; formic acid for the extraction of amikacin [84,85]; and methylene chloride for the extraction of isepamicin [62]. PPT aids in reducing interference during derivatization [7], and this may have accounted for its use by 41 articles.…”

Section: Sample Cleanupmentioning

confidence: 99%

“…Also, mass spectrometry can analyze small sample volumes with high precision, sensitivity, and selectivity [68,81]. In this review, 15 articles reported the use of mass spectrometry as a detector for the bioanalysis of neomycin, streptomycin, dihydrostreptomycin, amikacin, kanamycin, paromomycin, tobramycin, spectinomycin, apramycin, hygromycin, gentamicin, and arbekacin [5,31,[33][34][35]68,69,72,73,75,79,81,[83][84][85]. Interestingly, articles published between 1977 [20] to 2002 [67] were dominated by fluorescence or UV detection methods.…”

Section: A D V a N C E D O N L I N E A R T I C L Ementioning

confidence: 99%

“…Interestingly, articles published between 1977 [ 20 ] to 2002 [ 67 ] were dominated by fluorescence or UV detection methods. More importantly, mass spectrometry was the mostly used detection mode from 2014 to 2020 [ 34 , 35 , 81 , 83-85 ], except in one case [ 82 ]. This is not surprising as mass spectrometry appears to be an effective detection method [ 103 ].…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

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Bioanalysis of aminoglycosides using high-performance liquid chromatography

et al. 2022

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Aminoglycosides are broad-spectrum antibiotics used in the treatment of gram-negative bacterial infections. Due to their nephrotoxic and ototoxic potential (narrow therapeutic index), the use of aminoglycoside for clinical indications requires monitoring. The objective of this review was to identify relevant literature reporting liquid chromatographic methods for the bioanalysis of aminoglycosides in both preclinical and clinical settings/experiments. Data on liquid chromatographic methods were collected from articles in an online academic database (PubMed, Science Direct, Scopus, and Google Scholar). All 71 articles published from 1977 to 2020 were included in the review. Reversed-phase liquid chromatography was the most used method for the bioanalysis of aminoglycosides. Fluorescence or ultraviolet detection methods were mostly used from 1977 to 2002 (51 articles), while mass spectrometry was predominantly used as a detector from 2003 to 2020 (15 articles). Sixty-seven articles reported calibration ranges, which varied significantly for the various drugs assayed: some in the range of 0.1-0.5 ng/mL and others 1250-200000 ng/mL. Also, 61 articles reported R2 values (0.964-1.0) for almost all analytes under consideration. Sixty-three articles reported percent recoveries mostly between 61.0 % to 114.0 %, with only two articles reporting recoveries of 4.9 % and 36 %. Out of the 71 reviewed articles, 56 reported intermediate precision values ranging between 0.331 % to 19.76 %, which is within the acceptable limit of 20 %. This review will serve as a guide for research and/or routine clinical monitoring of aminoglycosides in biological matrices.

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Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs

Roseboom

Rosing

Beijnen

et al. 2022

Biomedical Chromatography

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Bioanalytical method development and validation for the quantification of antileishmanial drugs are pivotal to support clinical trials and provide the data necessary to conduct pharmacokinetic (PK) analysis. This review provides a comprehensive overview of published validated bioanalytical assays for the quantification of antileishmanial drugs amphotericin B, miltefosine, paromomycin, pentamidine, and pentavalent antimonials in human matrices. The applicability of the assays for leishmaniasis clinical trials as well as their relevance to PK studies with emphasis on the choice of matrix, calibration range, sample volume, sample preparation, choice of internal standards, separation, and detection was discussed for each antileishmanial drug. Given that no published bioanalytical methods included multiple antileishmanial drugs in a single assay although antileishmanial shortened combination regimens currently were under investigation, it was recommended to combine various drugs in a single bioanalytical method. Furthermore, bioanalytical method development regarding target site matrix as well as applying microsampling strategies was recommended to optimize future clinical PK studies in leishmaniasis.

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Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma

Cited by 10 publications

References 24 publications

Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone

Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone

Bioanalysis of aminoglycosides using high-performance liquid chromatography

Bioanalytical methods for pharmacokinetic studies of antileishmanial drugs

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