Highly specific selenium nanosystems for fluorescent image-guided rapid diagnosis and pathological grading of ovarian malignant tumors

Zheng, Shaolie; Li, Nan; Yuan, Songliu; Wang, Xiaoyu; Chen, Tianfeng

doi:10.1016/j.cclet.2022.107764

Cited by 4 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fortunately, advances in nanotechnology offer great promise for the diagnosis and treatment of ovarian cancer. 7,8 Autophagy is a conserved catabolic process that maintains intracellular homeostasis by degrading intracellular biomolecules and damaged organelles. 9 However, an excessive and prolonged autophagy may lead to the death of autophagic cells.…”

Section: Introductionmentioning

confidence: 99%

“…Ovarian cancer is a common malignant tumor of the female reproductive system, ranking just behind cervical and endometrial cancers in terms of incidence and exhibiting high mortality, recurrence, and low survival rates. , Currently, ovarian cancer is treated with surgery to shrink the tumor followed by multidrug chemotherapy with platinum or paclitaxel-like compounds. , However, inherent or acquired chemoresistance in ovarian cancer severely affects the efficacy of chemotherapy. , Therefore, there is an urgent need to find new strategies to improve the outcome of ovarian cancer treatment. Fortunately, advances in nanotechnology offer great promise for the diagnosis and treatment of ovarian cancer. , …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Zhu,

Hu,

Yang

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Chemotherapy resistance is a major cause of the high mortality in ovarian cancer. Therefore, there is an urgent need to develop strategies to increase the sensitivity of ovarian cancer to chemotherapeutic medicines. Here, we synthesized nucleic acid aptamer (NucA)-modified zinc ferrite nanoparticles (NAZs), to induce pro-death autophagy for enhancing the sensitivity of ovarian cancer cells to the chemotherapeutic agent�cisplatin (DDP). First, we verified that zinc ferrite nanoparticles (ZFONPs) effectively induced intact cellular autophagy in SKOV3 cells. Moreover, the use of small-molecule autophagy inhibitors markedly curtailed cell death induced by ZFONPs. Notably, we found that ZFONPs-induced pro-death autophagy was mediated by increasing zinc ion release and thereby intracellular reactive oxygen species (ROS) production. Second, we demonstrated that the modification of ZFONPs with the tumor-targeting aptamer (NucA) endowed the nanoparticles with the ability to target tumor cells. Furthermore, the induction of deathpromoting autophagy by NAZs sensitized ovarian cancer cells to DDP chemotherapy. Significantly, the constructed NAZs exhibited ovarian cancer targeting capabilities, served as T 2 -weighted magnetic resonance imaging (MRI) contrast agents, and enhanced the therapeutic effect of DDP in both in vitro and in vivo experiments. Collectively, these findings present a promising and effective approach for the precise treatment and diagnosis of ovarian cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Zhu,

Hu,

Yang

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

Rapid Selenoprotein Activation by Selenium Nanoparticles to Suppresses Osteoclastogenesis and Pathological Bone Loss

Zou,

Xiong,

et al. 2024

Advanced Materials

Self Cite

View full text Add to dashboard Cite

Osteoclast hyperactivation stands as a significant pathological factor contributing to the emergence of bone disorders driven by heightened oxidative stress levels. The modulation of the redox balance to scavenge reactive oxygen species (ROS) emerges as a viable approach in addressing this concern. Selenoproteins, characterized by selenocysteine (SeCys2) as the active center, are crucial for selenium‐based antioxidative stress therapy for inflammatory diseases. This study reveals that surface‐active elemental selenium (Se) nanoparticles, particularly those derived from lentinan (LNT‐Se), exhibit enhanced cellular accumulation and accelerated metabolism to SeCys2, the primary active Se form in biological systems. Consequently, LNT‐Se demonstrates significant inhibition of RANKL‐induced osteoclastogenesis and osteoclastic activity when compared to alternative Se species. Furthermore, in vivo studies underscore the superior therapeutic efficacy of LNT‐Se over SeCys2, potentially attributable to the enhanced stability and safety profile of LNT‐Se. Specifically, LNT‐Se effectively modulates the expression of the selenoprotein GPx1, thereby exerting regulatory control over macrophage polarization, osteoclast activity inhibition, and the prevention of CIA/OVX‐induced osteolysis. In summary, these results suggest that the prompt activation of selenoproteins by Se nanoparticles serves to suppress osteoclastogenesis and pathological bone loss by upregulating GPx1 to re‐polarize macrophages. Moreover, the utilization of bioactive Se species presents a promising avenue for effectively managing bone disorders, with considerable potential for clinical translation.This article is protected by copyright. All rights reserved

show abstract

Selenol Switch Assay for Selenoprotein Derivatization

Wei,

Zhang,

Shi

et al. 2024

ChemBioChem

View full text Add to dashboard Cite

Selenoproteins are a class of protein that have selenocysteine (Sec) residues, and essential for diverse cellular functions. Although the human genome encodes 25 selenoproteins, nearly half of these selenoproteins’ function is not clear. This is largely due to the lack of convenient methods to study selenoproteins. We report in this work a novel Selenol Switch assay to exclusively derivatize selenoproteins. The Selenol Switch assay relies on the selective conversion of the Sec residue to the electrophilic dehydroalanine (DHA) residue, which is then labeled by nucleophiles. The multiple reactions of the Selenol Switch assay are readily performed in a single test tube, and the conversion yield is nearly quantitative. The abundance of selenoproteins in mouse tissues determined by the Selenol Switch assay is consistent with that from the classical ICP‐MS assay, validating the reliability of the Selenol Switch assay in studying selenoproteins.

show abstract

Highly specific selenium nanosystems for fluorescent image-guided rapid diagnosis and pathological grading of ovarian malignant tumors

Cited by 4 publications

References 36 publications

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Rapid Selenoprotein Activation by Selenium Nanoparticles to Suppresses Osteoclastogenesis and Pathological Bone Loss

Selenol Switch Assay for Selenoprotein Derivatization

Contact Info

Product

Resources

About