Highly stable intrinsically radiolabeled indium-111 quantum dots with multidentate zwitterionic surface coating: dual modality tool for biological imaging

Sun, Minghao; Sundaresan, Gobalakrishnan; Jose, Purnima; Yang, Likun; Hoffman, David; Lamichhane, Narottam; Zweit, Jamal

doi:10.1039/c4tb00296b

Cited by 32 publications

(32 citation statements)

References 49 publications

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“…A similar compound to 6 has been reported by Sun et al . (structure 7 , Figure ), and employed in the development of 109 Cd‐radiolabeled quantum dots detectable by both optical imaging and gamma counting.…”

Section: Zwitterionic Coatings: a Viable Route Forward?mentioning

confidence: 80%

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

García

Zarschler

Barbaro

et al. 2014

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Nanoparticles represent highly promising platforms for the development of imaging and therapeutic agents, including those that can either be detected via more than one imaging technique (multi-modal imaging agents) or used for both diagnosis and therapy (theranostics). A major obstacle to their medical application and translation to the clinic, however, is the fact that many accumulate in the liver and spleen as a result of opsonization and scavenging by the mononuclear phagocyte system. This focused review summarizes recent efforts to develop zwitterionic-coatings to counter this issue and render nanoparticles more biocompatible. Such coatings have been found to greatly reduce the rate and/or extent of non-specific adsorption of proteins and lipids to the nanoparticle surface, thereby inhibiting production of the "biomolecular corona" that is proposed to be a universal feature of nanoparticles within a biological environment. Additionally, in vivo studies have demonstrated that larger-sized nanoparticles with a zwitterionic coating have extended circulatory lifetimes, while those with hydrodynamic diameters of ≤5 nm exhibit small-molecule-like pharmacokinetics, remaining sufficiently small to pass through the fenestrae and slit pores during glomerular filtration within the kidneys, and enabling efficient excretion via the urine. The larger particles represent ideal candidates for use as blood pool imaging agents, whilst the small ones provide a highly promising platform for the future development of theranostics with reduced side effect profiles and superior dose delivery and image contrast capabilities.

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Section: Zwitterionic Coatings: a Viable Route Forward?mentioning

confidence: 80%

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

García

Zarschler

Barbaro

et al. 2014

Small

450

371

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“…With the availability of a large number of isotopes that are suitable for PET imaging applications, 86 it will be desirable to use the isotope with a decay half-life that matches the circulation half-life of the nanomaterial of interest in future studies of radiolabeled nanomaterials. 5, 87 …”

Section: Tissue Engineering With Graphene-based Nanomaterialsmentioning

confidence: 99%

Graphene: a versatile nanoplatform for biomedical applications

et al. 2012

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Graphene, with its excellent physical, chemical, and mechanical properties, holds tremendous potential for a wide variety of biomedical applications. As research on graphene-based nanomaterials is still at a nascent stage, due to the very short time span since its initial report in 2004, a focused review on this topic is timely and necessary. In this feature review, we first summarize the results from toxicity studies of graphene and its derivatives. Although literature reports have mixed findings, we emphasize that the key question is not how toxic graphene itself is, but how to modify and functionalize it and its derivatives so that they do not exhibit acute/chronic toxicity, can be cleared from the body over time, and thereby can be best used for biomedical applications. Next, we discuss in detail the exploration of graphene-based nanomaterials for tissue engineering, molecular imaging, and drug/gene delivery applications. The future of graphene-based nanomaterials in biomedicine looks brighter than ever, and it is expected that they will find a wide range of biomedical applications with future research effort and interdisciplinary collaboration.

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“…For radiolabeling, QDs can be coated with various radioactive materials for PET measurements, such as 65Zn (PET) and 111 In (SPECT) (Stachowski et al 2014;Sun et al 2014). This technique requires particle size homogeneity for reliable results and may provide improved sensitivity, especially when combined with fluorescent QDs (Jaiswal et al 2004;Stachowski et al 2014).…”

Section: Spect Imagingmentioning

confidence: 99%

“…This, however, leads to the necessity of injection of the radioactive tracer substrate for every measurement. Recent research proposed the use of radiolabeled QDs and nanoparticles as CAs for PET/SPECT (Bargheer et al 2015;Sun et al 2014Sun et al , 2015.…”

Section: Radioscintigraphy: Pet and Spectmentioning

confidence: 99%

Lost signature: progress and failures in in vivo tracking of implanted stem cells

Haar

Lavrentieva

Stahl

et al. 2015

Appl Microbiol Biotechnol

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Stem cell therapy as a part of regenerative medicine provides promising approaches for the treatment of injuries and diseases. The increasing use of mesenchymal stem cells in various medical treatments created the demand for long-term in vivo cell tracking methods. Therefore, it is necessary to analyze post-transplantational survival, biodistribution, and engraftment of cells. Furthermore, stem cell treatment has been discussed controversially due to possible association with tumor formation in the recipient. For therapeutic purpose, stem cells must undergo substantial manipulation such as differentiation and in vitro expansion, and this can lead to the occurrence of genetic aberrations and altered expression of both tumor suppression and carcinogenic factors. To control therapy, it is necessary to find a reliable and general method to track and identify implanted cells in the recipient. This is especially challenging for autologous transplantations, as standard fingerprinting methods cannot be applied. An optimal technique for in vivo cell monitoring does not yet exist, and its development holds several challenges: small numbers of transplanted cells, possibility of cell number quantification, minimal transfer of the contrast agent to non-transplanted cells, and no genetic modification. This review discusses most of the proposed solutions, including magnetic resonance imaging, magnetic particle imaging, positron emission tomography, single-photon emission computed tomography, and optical imaging methods. Additionally, the recent research on cell labeling for stem cell monitoring after transplantation including in vitro, ex vivo, and in vivo imaging studies is described. Promising future imaging modalities for stem cell monitoring after transplantation are shown.

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Highly stable intrinsically radiolabeled indium-111 quantum dots with multidentate zwitterionic surface coating: dual modality tool for biological imaging

Abstract: A highly stable bimodal indium(111) radiolabeled indium QDs were synthesized for in vivo SPECT/fluorescence imaging.

Cited by 32 publications

References 49 publications

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

Graphene: a versatile nanoplatform for biomedical applications

Lost signature: progress and failures in in vivo tracking of implanted stem cells

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