Highly stable molybdenum dioxide nanoparticles with strong plasmon resonance are promising in photothermal cancer therapy

Liu, Wei; Li, Xinshi; Li, Wentao; Zhang, Qiqi; Bai, Hua; Li, Junfang; Xi, Guangcheng

doi:10.1016/j.biomaterials.2018.02.021

Cited by 59 publications

(50 citation statements)

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“…However, most of the reported TMOs suffer from relatively low photothermal conversion efficiencies (PTCEs) in NIR-II region. As an emerging type of NIR plasmonic semiconductor, oxygen-deficient molybdenum oxides (MoO x , 2 ≤ x < 3) have seen a remarkable burst of interest due to the lowcost synthesis, tunable band gap and pH-dependent oxidative degradation [26][27][28]. For example, Yin et al [29] synthesized small-sized MoO x nanoparticles with a wide light absorption from 600 to 1200 nm using the facile hydrothermal method.…”

Section: Introductionmentioning

confidence: 99%

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo

Zhang

et al. 2020

Sci. China Mater.

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Research on deep-tissue photothermal therapy (PTT) in the near-infrared II (NIR-II, 1000-1350 nm) region has bloomed in recent years, owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I (NIR-I, 650-950 nm) region. However, more details need to be uncovered to facilitate a fundamental understanding of NIR-II PTT. Herein, a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide (MoO 2) nanoaggregates was fabricated. The photothermal conversion capabilities of MoO 2 in the NIR-I and II regions were investigated step by step, from a simple tissue phantom to a three-dimensional cellular system, and further to a tumor-bearing animal model. NIR-II laser exhibited a lower photothermal attenuation coefficient (0.541 at 1064 nm) in a tissue phantom compared with its counterpart (0.959 at 808 nm), which allows it to be more capable of deeptissue PTT in vitro and in vivo. Depth profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration depth. Moreover, the depth-related tumor ablation was also studied by Raman fingerprint analysis, which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues, providing fundamental knowledge to NIR-II deeptissue photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Guo

Zhang

et al. 2020

Sci. China Mater.

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“…uorescence. 33 As indicated in Fig. 5b, few dead cells could be found in both TiO 2 and g-Ti 3 O 5 HPMs exposure groups without laser irradiation.…”

Section: Stability Of G-ti 3 O 5 Hpms In Physiological Mediummentioning

confidence: 58%

“…The photothermal conversion efficiency of g-Ti 3 O 5 HPMs was calculated according to the method in former research. 31,33,[42][43][44] The calculate detail was described in ESI. † The photothermal conversion efficiency (h) of g-Ti 3 O 5 HPMs irradiated by 808 nm laser can be calculated to be 65.29%.…”

Section: Photothermal Property Under Nir Irradiationmentioning

confidence: 99%

“…The tumor model developed as the method in former works. 33,38 The mice were randomly divided into 3 groups (5 mice per group) and injected with 100 mL PBS, TiO 2 and g-Ti 3 O 5 HPMs (0.5 mg mL À1 in PBS) respectively into the tumor of the mice by intratumor injection. 1.5 h later, the entire region of the tumor was irradiated with the 808 nm NIR laser (1 W cm À2 ) for 10 min.…”

Section: In Vivo Toxicity and Photothermal Experimentsmentioning

confidence: 99%

“…32) et al Among these PTT agents, oxygen vacancy-rich transition metal oxides are considerable appealing owing to their metallic features, strong localized surface plasmon resonance (LSPR) effect, low cost and easy synthesis. 33 Furthermore, the application of titanium oxides nanoparticles in cosmetics as ultraviolet absorbents has been proved to be effective and biocompatible. Recently, some research reported that the titanium oxides nanoparticles could be used as photodynamic therapy (PDT) agent by utilizing its strong UV absorption.…”

Section: Introductionmentioning

confidence: 99%

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Metallic Ti₃O₅ hierarchical porous microspheres with an enhanced photothermal property

Liu

Bai

et al. 2020

RSC Adv.

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Plasmonic Oxygen Defects in MO₃₋_x (M = W or Mo) Nanomaterials: Synthesis, Modifications, and Biomedical Applications

Zhou

Liu

et al. 2021

Adv Healthcare Materials

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Nanomedicine is a promising technology with many advantages and provides exciting opportunities for cancer diagnosis and therapy. During recent years, the newly developed oxygen-deficiency transition metal oxides MO 3−x (M = W or Mo) have received significant attention due to the unique optical properties, such as strong localized surface plasmon resonance (LSPR) , tunable and broad near-IR absorption, high photothermal conversion efficiency, and large X-ray attenuation coefficient. This review presents an overview of recent advances in the development of MO 3−x nanomaterials for biomedical applications. First, the fundamentals of the LSPR effect are introduced. Then, the preparation and modification methods of MO 3−x nanomaterials are summarized. In addition, the biological effects of MO 3−x nanomaterials are highlighted and their applications in the biomedical field are outlined. This includes imaging modalities, cancer treatment, and antibacterial capability. Finally, the prospects and challenges of MO 3−x and MO 3−x -based nanomaterial for fundamental studies and clinical applications are also discussed.

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Highly stable molybdenum dioxide nanoparticles with strong plasmon resonance are promising in photothermal cancer therapy

Cited by 59 publications

References 50 publications

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Metallic Ti₃O₅ hierarchical porous microspheres with an enhanced photothermal property

Plasmonic Oxygen Defects in MO₃₋_x (M = W or Mo) Nanomaterials: Synthesis, Modifications, and Biomedical Applications

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Highly stable molybdenum dioxide nanoparticles with strong plasmon resonance are promising in photothermal cancer therapy

Cited by 59 publications

References 50 publications

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

Metallic Ti3O5 hierarchical porous microspheres with an enhanced photothermal property

Plasmonic Oxygen Defects in MO3−x (M = W or Mo) Nanomaterials: Synthesis, Modifications, and Biomedical Applications

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Product

Resources

About

Metallic Ti₃O₅ hierarchical porous microspheres with an enhanced photothermal property

Plasmonic Oxygen Defects in MO₃₋_x (M = W or Mo) Nanomaterials: Synthesis, Modifications, and Biomedical Applications