Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats

Filho, Machado; Loiola, Raphael T.; Rocha, Eduardo Lima da; Simão, Antônio Felipe; Gomes, Antoniela S.; Souza, Marcellus H.; Ribeiro, Ronaldo A.

doi:10.1590/s0100-879x2009005000025

Cited by 26 publications

(21 citation statements)

References 35 publications

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“…Even though ischemia/reperfusion can be deleterious to the muscle, transient ischemic preconditioning (repeated short episodes of ischemia/reperfusion) of the limb elicits local and systemic anti-inflammatory effects in rats (136), protects against local muscle damage, and confers remote cardiac and liver protection from subsequent acute ischemia of these tissues (24,161). This suggests that skeletal muscle produces anti-inflammatory factors that can systemically protect itself and other tissues from the deleterious effects of inflammation.…”

Section: Molecular Aspects Of Skeletal Muscle Inflammationmentioning

confidence: 99%

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Pillon

Bilan

Fink

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

246

220

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Section: Molecular Aspects Of Skeletal Muscle Inflammationmentioning

confidence: 99%

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Pillon

Bilan

Fink

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

246

220

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“…A study [35] was carried out in rats for the evaluation of IPC and RIPC for protection against right paw edema induced by carrageenan or dextran, with reduction of edema with IPC in the ipsilateral paw, and also in another group with RIPC in the left paw protecting the contralateral paw. Dextran edema occurs by degranulation of mast cells with a low protein concentration in the fluid and few neutrophils.…”

Section: Introductionmentioning

confidence: 99%

“…RIPC protects the lesion from ifosfamide by acting on the reduction in TNF-α and IL-1. The cytokines involved in RIPC appear to be TNF-α, IL-1, and iNOS [35]. …”

Section: Introductionmentioning

confidence: 99%

Effect of Remote Ischemic Preconditioning on Systemic Toxicity and Ototoxicity Induced by Cisplatin in Rats: Role of TNF-α and Nitric Oxide

Mjb

Ama²,

Ynf³

et al. 2017

ORL

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Background/Aims: Cisplatin is a chemotherapeutic agent. The use of remote ischemic preconditioning (RIPC) was proposed after the observation that ischemic preconditioning of a cardiac vascular area could protect another completely distinctly. Methods: This is an experimental study. Male Wistar rats were anesthetized, and they underwent a hearing evaluation via measurement of the brainstem auditory evoked potential (BSAEP). Then, cisplatin was administered intraperitoneally (IP) at a dose of 8 mg/kg/day for 4 consecutive days to group 1, whereas saline solution was administered IP to group 2. In groups 3 and 4, ischemia of the right hind paw was performed for 10 min, followed by reperfusion for 30 min, after which cisplatin or saline was administered IP to group 3 or group 4, respectively. Afterwards, all animals were evaluated via the BSAEP. The right cochlea was dissected for immunohistochemistry. Results: RIPC lowered the increase in BSAEP of the animals treated with cisplatin (p = 0.0146). Weight loss decreased in the animals subjected to RIPC (p < 0.005). In group 3, RIPC reversed immunostaining for tumor necrosis factor-α and inducible nitric oxide synthase in the stria vascularis injured by cisplatin (p < 0.05). Conclusion: RIPC protects against systemic toxicity and ototoxicity induced by cisplatin in rats.

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“…Ischemic Remote Preconditioning (IPCr) is a strategy that also has demonstrated promising results in local and systemic tolerance against hypoxia and reoxygenation. The IPCr protects the organs exposed to lethal ischemia and the magnitude of protection is equivalent to the IPC, through the release of biochemical messengers in the circulation or by activation of neuronal pathways, or a combination of both 11,12 .…”

Section: Ischemic Preconditioning (Ipc) Is a Technique Thatmentioning

confidence: 99%

“…The pregnant rat was submitted to ischemic preconditioning 24 hours before delivery by applying a rubber band tourniquet 11 , by using an elastic band in the proximal region of the left hind paw. It was induced 10 minutes of ischemia, after what the tourniquet was removed allowing reperfusion.…”

Section: Remote Ischemic Preconditioning Protocolmentioning

confidence: 99%

Effects of maternal ischemic preconditioning in the colon of newborn rats submitted to hypoxia-reoxygenation insult

et al. 2014

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PURPOSE:To evaluate the effects of maternal remote ischemic preconditioning (IPCr) in the colonic mucosa of newborn rats subjected to hypoxia and reoxygenation. METHODS:Newborn Wistar rats were divided into three groups. Control Group (CG), Hypoxia and Reoxygenation Group (HRG) and Remote Ischemic Preconditioning Group (IPCrG). Hypoxia and reoxygenation was performed 2x per day, with an interval of 6 hours, on the 1st, 2nd and 3rd days of life, with 10 minutes of CO 2 at 100%, followed by 10 minutes O 2 at 100%(HRG/IPCrG). The maternal IPCr was performed 24 hours before delivery by applying a rubber band tourniquet to the left hind limb (IPCrG). Segments of the colon underwent histological (HE) and immunohistochemical analysis for caspase-3 and COX -2. RESULTS:The histological findings showed no intestinal mucosal damage in the CG group and severe lesions in HRG that was attenuated in the IPCrG (p<0.05). The expression of the apoptotic cells was lower in the HRG group than in the CG and IPCrG. The COX-2 expression was intense in HRG and attenuated in the IPCrG (p<0.05). CONCLUSIONS:Maternal IPCr protected the colonic mucosa of newborn rats subjected to hypoxia and reoxygenation, reducing the morphological alterations and inflammatory response. It ameliorates the occurrence of apoptosis, keeping the physiological process of renewal and regeneration in the epithelial lining of the colonic mucosa.Key words: Enterocolitis, Necrotizing. Colon. Apoptosis. Rats. Effects of maternal ischemic preconditioning in the colon of newborn rats submitted to hypoxia-reoxygenation insultActa

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Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats

Cited by 26 publications

References 35 publications

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Effect of Remote Ischemic Preconditioning on Systemic Toxicity and Ototoxicity Induced by Cisplatin in Rats: Role of TNF-α and Nitric Oxide

Effects of maternal ischemic preconditioning in the colon of newborn rats submitted to hypoxia-reoxygenation insult

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