Hindbrain structures involved in pain processing as revealed by the expression of c-Fos and other immediate early gene proteins

́ri-Minet, M. Lante; Weil-Fugazza, J.; Pommery, J. de; ́trey, D. Mene

doi:10.1016/0306-4522(94)90035-3

Cited by 106 publications

(45 citation statements)

References 56 publications

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“…Indeed, a notable increase in c-Fos expression in the PB area has been observed after gingival injection of interleukin-1-b and tooth pulp stimulation (Hamba et al, 1994) or intraplantar injection of formalin (Pertovaara et al, 1993;Lantéri-Minet et al, 1994). Although no quantitative data were provided in the study of Hamba et al (1994) performed under urethane 1 chloralose, the location of the evoked Fos-ir neurones roughly corresponds with our results.…”

Section: Heat-induced C-fos Expression At the Parabrachial Levelsupporting

confidence: 88%

Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes: A c-Fos study in the rat

et al. 1997

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We have analysed in briefly anaesthetised rats (1% halothane for 18 minutes) the effects of innocuous and noxious heat, applied to the hindpaw, on evoked c-Fos immunoreactivity at the levels of the parabrachial area (PB), spinal cord, and nucleus of the solitary tract (NTS). After anaesthesia recovery, animals were left to move freely for 2 hours. At the spinal level, c-Fos was expressed primarily in the ipsilateral superficial laminae, increasing with the applied temperatures in a dependent manner in the noxious range (correlation coefficient r = 0.954, n = 20). At the NTS level, no noxiously evoked c-Fos expression was observed. At the PB level, c-Fos was expressed preferentially contralaterally, increasing with the applied temperatures in a dependent manner in the noxious range (r = 0.971, n = 25). The maximum expression was observed in the outer portion of the external lateral, the lateral crescent, and the superior lateral subnuclei around the pontomesencephalic junction. This was congruent with the densest supraspinal projection of lamina I neurones of the dorsal horn. Labelling in the PB area was highly correlated (r = 0.936, n = 20) with labelling in the superficial laminae. We conclude that, under our experimental procedures, noxious heat-induced c-Fos expression at the PB level depends on the intensity of the noxious stimulation. These data further support the relevance of the recently described spino-PB pain pathway. Because of their location, the Fos-immunoreactive neurones observed in the pontine and the mesencephalic divisions of the PB area were likely PB-amygdaloid and PB-hypothalamic nociceptive neurones, respectively.

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Section: Heat-induced C-fos Expression At the Parabrachial Levelsupporting

confidence: 88%

Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes: A c-Fos study in the rat

et al. 1997

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“…Because FLI induction in 5SP did not exceed that in controls, presumably nociceptive laryngeal afferents terminating in 5SP (Lucier et al, 1986) may have not been activated by SLN stimulation. In addition, codeine failed to reduce FLI in brainstem nuclei implicated in pain integration (5SP, n.com, and NPBL) (Lantéri-Minet et al, 1994). Thus, the marked FLI reduction observed in stimulated-treated cats likely resulted from the antitussive properties of codeine rather than its analgesic properties.…”

Section: Significance Of Reduced Fli In Stimulated-treated Catsmentioning

confidence: 87%

Differential Brainstem Fos-Like Immunoreactivity after Laryngeal-Induced Coughing and Its Reduction by Codeine

1997

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We used the expression of the immediate-early gene c-fos, a marker of neuronal activation, to localize brainstem neuronal populations functionally related to fictive cough (FC). In decerebrate, paralyzed, and ventilated cats, the level of Fos-like immunoreactivity (FLI) was examined in five groups of animals: (1) controls, sham-operated unstimulated animals; (2) coughing cats, including both animals in which FC was elicited by unilateral electrical stimulation of the superior laryngeal nerve (SLN) and (3) those in which FC was elicited by bilateral SLN stimulation; (4) stimulated-treated cats, in which bilateral SLN stimulation was applied after selective blockade of FC by codeine; and (5) codeine controls, sham-operated unstimulated cats subjected to administration of codeine. Fifteen brainstem structures were compared for numbers of labeled cells. Because codeine selectively blocks FC, brainstem nuclei activated specifically during FC were identified as regions showing increased FLI after FC and significant reductions in FLI after FC suppression by codeine in stimulated-treated cats. In coughing animals, we observed a selective immunoreactivity in the interstitial and ventrolateral subdivisions of the nucleus of the tractus solitarius, the medial part of the lateral tegmental field, the internal division of the lateral reticular nucleus, the nucleus retroambiguus, the para-ambigual region, the retrofacial nucleus, and the medial parabrachial nucleus. FLI in all these nuclei was significantly reduced in stimulated-treated cats. Our results are consistent with the involvement of neurons overlapping the main brainstem respiratory-related regions as well as the lateral tegmental field and the lateral reticular nucleus in the neural processing of laryngeal-induced FC.

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“…Pain inflicted to a conscious animal by the subcutaneous injection of capsaicin (Ceccatelli et al, 1989;Honkaniemi et al, 1994) or formalin (Senba et al, 1993;Lantéri-Minet et al, 1994) has been shown to raise Fos-IR cell numbers in the forebrain, midbrain, and medullary CA nuclei with a distribution similar to that occurring after a processive stressor, like restraint (Cullinan et al, 1995). This may result from the psychological distress provoked in the animals by conscious pain.…”

Section: Supraspinal C-fos Activation By Noxious Stimulationmentioning

confidence: 93%

Central afferent pathways conveying nociceptive input to the hypothalamic paraventricular nucleus as revealed by a combination of retrograde labeling and c-fos activation

Pan¹,

Castro‐Lopes²,

Coimbra³

1999

J. Comp. Neurol.

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Hindbrain structures involved in pain processing as revealed by the expression of c-Fos and other immediate early gene proteins

Cited by 106 publications

References 56 publications

Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes: A c-Fos study in the rat

Further evidence for the involvement of the spinoparabrachial pathway in nociceptive processes: A c-Fos study in the rat

Differential Brainstem Fos-Like Immunoreactivity after Laryngeal-Induced Coughing and Its Reduction by Codeine

Central afferent pathways conveying nociceptive input to the hypothalamic paraventricular nucleus as revealed by a combination of retrograde labeling and c-fos activation

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