Hinge and Twist Rigid Body Domain Motions in Ionotropic Glutamate Receptor GluR6 and the Hydrogen Bond Interactions that Switch Them On and Off

Abstract

prefers to open to the intermediate and large conductance states. In the presence of the willardiine partial agonists, the channel opens more frequently to the smallest and intermediate conductance states. Kinetic modeling using maximum interval likelihood rate optimization revealed two time constants in each open state and at least three in the closed state for the partial and the full agonists. These data suggest the mode of channel activation is similar for both glutamate and willardiine compounds with varying rates of activation. Supported by NIH NS049223.