Hip involvement in juvenile idiopathic arthritis

Rostom, S.; Amine, Bouchra; Bensabbah, R.; Abouqal, Rédouane; Hajjaj–Hassouni, N.

doi:10.1007/s10067-008-0853-9

Cited by 31 publications

(27 citation statements)

References 4 publications

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“…Inflammation of the spine and coxofemoral joints is an indicator of more serious forms of the disease. 19,36,37 In our study, spreading to the cervical spine and coxofemoral joints arthritis were only found in children with detectable IL-17A values in the active phase of JIA. Therefore, children with detectable IL-17A levels should be closely monitored, and such results imply that, on the basis of IL-17A values in the initial phase of JIA, it may be possible to select patients at a higher risk from a worse functional outcome.…”

Section: Discussioncontrasting

confidence: 46%

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

et al. 2017

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Objectives: This study aims to determine the serum levels of interleukin-17A (IL-17A) in children with juvenile idiopathic arthritis (JIA) and analyze the correlation between IL-17A values and disease activity, certain clinical features, and laboratory markers of inflammation. Patients and methods:The study included 30 children (7 boys, 23 girls; mean age 8.8±5.3 years; range 1 to 18 years), who had been diagnosed with JIA (18 children were diagnosed during the study period and 12 children were diagnosed before the start of the study) and had active disease during the study period. Control group included 30 healthy, age-and sex-matched children (9 boys, 21 girls; mean age 8.3±4.8 years; range 1 to 18 years). The enzyme-linked immunosorbent assay was used to assess the serum IL-17A levels of children with JIA in the active phase of the disease and control group. Clinical and laboratory features of the disease were evaluated for the children with JIA. Results: Serum levels of IL-17A in children with JIA were significantly higher in comparison to control group. In children with JIA who were prospectively monitored, statistically significantly decreased IL-17A level was recorded in the inactive phase of the disease. The incidence of arthritis of coxofemoral joints was significantly more common, and the mean levels of erythrocyte sedimentation rate and C-reactive protein were significantly higher in the group of children with JIA with detectable levels of IL-17A. Children with JIA and detectable levels of IL-17A had significantly higher values of Juvenile Arthritis Disease Activity Score-27 in comparison to children with JIA and non-detectable IL-17A. Conclusion: Assessment of serum IL-17A levels in early phases of JIA gives an opportunity for early detection of children that have higher risk for worse functional outcome.

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Section: Discussioncontrasting

confidence: 46%

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

et al. 2017

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“…Rostom et al 55 observed CR hip disease to start after 4 years of disease, whereas 80% had developed hip disease at 6 years, and 100% after 14 years. Other studies describing radiological features of JIA found most CR changes in the hands (57%), knees (47%), ankles (27%) and feet (36%), with erosions mainly in hands (18%) and feet (25%) 56.…”

Section: Resultsmentioning

confidence: 99%

EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice

et al. 2015

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To develop evidence based points to consider the use of imaging in the diagnosis and management of juvenile idiopathic arthritis ( JIA) in clinical practice. The task force comprised a group of paediatric rheumatologists, rheumatologists experienced in imaging, radiologists, methodologists and patients from nine countries. Eleven questions on imaging in JIA were generated using a process of discussion and consensus. Research evidence was searched systematically for each question using MEDLINE, EMBASE and Cochrane CENTRAL. Imaging modalities included were conventional radiography, ultrasound, MRI, CT, scintigraphy and positron emission tomography. The experts used the evidence obtained from the relevant studies to develop a set of points to consider. The level of agreement with each point to consider was assessed using a numerical rating scale. A total of 13 277 references were identified from the search process, from which 204 studies were included in the systematic review. Nine points to consider were produced, taking into account the heterogeneity of JIA, the lack of normative data and consequent difficulty identifying pathology. These encompassed the role of imaging in making a diagnosis of JIA, detecting and monitoring inflammation and damage, predicting outcome and response to treatment, use of guided therapies, progression and remission. Level of agreement for each proposition varied according to the research evidence and expert opinion. Nine points to consider and a related research agenda for the role of imaging in the management of JIA were developed using published evidence and expert opinion.

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“…4 Hip involvement in juvenile AS patients has been reported to be as high as 50%. 13 In juvenile-onset cases, bilateral involvement in which one side is more affected is frequently encountered. 13 In our study group, there was also bilateral synovial fluid and bone marrow edema in a patient who was 18 years old and who had been affected by the disease for four years.…”

Section: Discussionmentioning

confidence: 99%

“…13 In juvenile-onset cases, bilateral involvement in which one side is more affected is frequently encountered. 13 In our study group, there was also bilateral synovial fluid and bone marrow edema in a patient who was 18 years old and who had been affected by the disease for four years. In the patient group, the rate of early signs of hip involvement was found as 43.4%.…”

Section: Discussionmentioning

confidence: 99%

Early Diagnosis of Hip Joint Involvement of Ankylosing Spondylitis Using Magnetic Resonance Imaging in the Absence of Clinical and X-Ray Findings

et al. 2014

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Objectives: This study aims to describe magnetic resonance imaging (MRI) findings of hip joint involvement in ankylosing spondylitis (AS) in the absence of clinical and X-ray signs. Patients and methods: Between January 2012 and June 2012, 23 patients with AS without hip pain symptoms who were admitted to Adana Training and Research Hospital, Department of Physical Therapy and Rheumatology were included in the study. The control group consisted of 20 healthy individuals. All patients underwent MRI examination of both hips. Results: Of 23 patients, 10 (43.4%) had a pathological finding in at least one of the two sides based on the MRI findings. Seven patients demonstrated unilateral, and three patients demonstrated asymmetrically bilateral involvements. Bone marrow edema was present in six out of the 46 hip joints (13%). Eleven hip joints (24%) showed synovial fluid. One patient had bone marrow edema together with a subchondral cyst, while another patient demonstrated a combination of bone marrow edema and tendinitis. Conclusion: There may be hip joint involvement in AS patients even in the absence of clinical and X-ray signs. Early detection of bony abnormalities may prevent both the damage to the bone and the development of ankylosis.

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Hip involvement in juvenile idiopathic arthritis

Cited by 31 publications

References 4 publications

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

Interleukin-17A Levels Increase in Serum of Children With Juvenile Idiopathic Arthritis

EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice

Early Diagnosis of Hip Joint Involvement of Ankylosing Spondylitis Using Magnetic Resonance Imaging in the Absence of Clinical and X-Ray Findings

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