Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways

Hergovich, Alexander; Hemmings, Brian A.

doi:10.1016/j.semcdb.2012.04.001

Cited by 82 publications

(71 citation statements)

References 121 publications

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“…The MEN GTPase, Tem1p (Spg1), is thought to be the central switch in MEN regulation. MEN/SIN achieve the equal distribution of genetic material between mother and daughter cells through a kinase cascade that triggers the dephosphorylation and consequent inactivation of mitotic CDK1 (cyclin-dependent kinase 1; TR_70266, TV_36994, and TA_127794) by the serinethreonine phosphatase CDC14 (TR_27406, TV_61598, and TA_91339) (715,716).…”

Section: Ras-gtpasesmentioning

confidence: 99%

The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species

Schmoll

Dattenböck

Carreras-Villaseñor

et al. 2016

Microbiol Mol Biol Rev

164

195

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SUMMARYThe genusTrichodermacontains fungi with high relevance for humans, with applications in enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a broad, comprehensive overview of the genomic content of these species for “hot topic” research aspects, including CAZymes, transport, transcription factors, and development, along with a detailed analysis and annotation of less-studied topics, such as signal transduction, genome integrity, chromatin, photobiology, or lipid, sulfur, and nitrogen metabolism inT. reesei,T. atroviride, andT. virens, and we open up new perspectives to those topics discussed previously. In total, we covered more than 2,000 of the predicted 9,000 to 11,000 genes of eachTrichodermaspecies discussed, which is >20% of the respective gene content. Additionally, we considered available transcriptome data for the annotated genes. Highlights of our analyses include overall carbohydrate cleavage preferences due to the different genomic contents and regulation of the respective genes. We found light regulation of many sulfur metabolic genes. Additionally, a new Golgi 1,2-mannosidase likely involved inN-linked glycosylation was detected, as were indications for the ability ofTrichodermaspp. to generate hybrid galactose-containingN-linked glycans. The genomic inventory of effector proteins revealed numerous compounds unique toTrichoderma, and these warrant further investigation. We found interesting expansions in theTrichodermagenus in several signaling pathways, such as G-protein-coupled receptors, RAS GTPases, and casein kinases. A particularly interesting feature absolutely unique toT. atrovirideis the duplication of the alternative sulfur amino acid synthesis pathway.

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Section: Ras-gtpasesmentioning

confidence: 99%

The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species

Schmoll

Dattenböck

Carreras-Villaseñor

et al. 2016

Microbiol Mol Biol Rev

164

195

View full text Add to dashboard Cite

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“…Interestingly, a number differentially regulated S-phase genes also present E2F target genes in line with E2F requirement for S-phase progression (133). Beyond S-phase entry and progression, there is increasing evidence that the Hippo pathway is involved in the regulation of G2/M-phase (134). However, these functions seem to be independent of the Hippo downstream effectors YAP and TAZ and mainly mediated by MST1/2 and NDR kinases (reviewed in (134)).…”

Section: Transcriptional Control Of Proliferationmentioning

confidence: 99%

“…Beyond S-phase entry and progression, there is increasing evidence that the Hippo pathway is involved in the regulation of G2/M-phase (134). However, these functions seem to be independent of the Hippo downstream effectors YAP and TAZ and mainly mediated by MST1/2 and NDR kinases (reviewed in (134)). Additionally, LATS2 seems to be required for mitotic progression and cytokinesis (135).…”

Section: Transcriptional Control Of Proliferationmentioning

confidence: 99%

Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway

Ehmer

Sage

2016

Molecular Cancer Research

127

102

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The control of cell division is essential for normal development and the maintenance of cellular homeostasis. Abnormal cell proliferation is associated with multiple pathological states, including cancer. While the Hippo/YAP signaling pathway was initially thought to control organ size and growth, increasing evidence indicates that this pathway also plays a major role in the control of proliferation independent of organ size control. In particular, accumulating evidence indicates that the Hippo/YAP signaling pathway functionally interacts with multiple other cellular pathways and serves as a central node in the regulation of cell division, especially in cancer cells. Here recent observations are highlighted that connect Hippo/YAP signaling to transcription, the basic cell cycle machinery, and the control of cell division. Furthermore, the oncogenic and tumor suppressive attributes of YAP/TAZ are reviewed which emphasizes the relevance of the Hippo pathway in cancer.

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“…MOB1 was originally shown in yeast to regulate mitotic exit and modulate cytokinesis (24)(25)(26)(27)(28)(29). In Drosophila, dMOB1 (MATS) overexpression is tumor suppressive, while loss of dMOB1 triggers tumor development (17).…”

Section: Introductionmentioning

confidence: 99%

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

et al. 2012

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Mps one binder 1a (MOB1A) and MOB1B are key components of the Hippo signaling pathway and are mutated or inactivated in many human cancers. Here we show that intact Mob1a or Mob1b is essential for murine embryogenesis and that loss of the remaining WT Mob1 allele in Mob1a Δ/Δ 1b tr/+ or Mob1a Δ/+ 1b tr/tr mice results in tumor development. Because most of these cancers resembled trichilemmal carcinomas, we generated doublemutant mice bearing tamoxifen-inducible, keratinocyte-specific homozygous-null mutations of Mob1a and Mob1b (kDKO mice). kDKO mice showed hyperplastic keratinocyte progenitors and defective keratinocyte terminal differentiation and soon died of malnutrition. kDKO keratinocytes exhibited hyperproliferation, apoptotic resistance, impaired contact inhibition, enhanced progenitor self renewal, and increased centrosomes. Examination of Hippo pathway signaling in kDKO keratinocytes revealed that loss of Mob1a/b altered the activities of the downstream Hippo mediators LATS and YAP1. Similarly, YAP1 was activated in some human trichilemmal carcinomas, and some of these also exhibited MOB1A/1B inactivation. Our results clearly demonstrate that MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway.

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Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways

Cited by 82 publications

References 121 publications

The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species

The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species

Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

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