Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study

Cherbuin, Nicolas; Sargent‐Cox, Kerry; Easteal, Simon; Sachdev, Perminder S.; Anstey, Kaarin J.

doi:10.1016/j.jagp.2014.07.009

Cited by 61 publications

(47 citation statements)

References 41 publications

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“…Several of the impaired WM tracts connect structures involved in the early stages of AD, such as the hippocampus, the medial temporal lobe, and the posterior cingulate cortex [12, 31, 32]. Our results were generally consistent with previous research [19, 33], whose results suggested that underlying neurodegenerative changes have already occurred at the SCD stage and that DTI can contribute additional information at this stage.…”

Section: Discussionsupporting

confidence: 91%

White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

Tang

Sun

et al. 2016

Oncotarget

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Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer's disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3±8.0), 35 aMCI (age=69.2±8.6) and 25 AD patients (age=68.3±9.4) and 37 normal controls (NC) (age=65.1±6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p<0.05), increased mean diffusivity (MD; p<0.05), and increased radial diffusivity (RD; p<0.05). In addition, localized WM alterations showed increased axial diffusivity (AxD; p<0.05) similar to what was observed in aMCI and AD patients (p<0.05). In the shared WM impairment tracts, SCD patients had FA values between the NC group and the other two patient groups. In the NC and SCD groups, the AVLT-delayed recall score correlated with higher AxD (r=−0.333, p=0.045), MD (r=−0.351, p=0.03) and RD (r=−0.353, p=0.025). In both the aMCI and AD groups the diffusion parameters were highly correlated with cognitive scores. Our study suggests that SCD patients present with widespread WM changes, which may contribute to the early memory decline they experience.

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Section: Discussionsupporting

confidence: 91%

White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

Tang

Sun

et al. 2016

Oncotarget

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“…Subjective memory assessments appear to rely not only on the same processes or brain regions involved in the actual memory processes, e.g., hippocampal (Cherbuin et al, 2014; Erk et al, 2011; Hafkemeijer et al, 2013; Saykin et al, 2006; Scheef et al, 2012; Stewart et al, 2011; van der Flier, et al, 2004) or entorhinal cortex (Jessen et al, 2006) structure or function, but subjective memory assessment also likely relies on a more cortical network of brain regions, including at least the prefrontal cortex and precuneus (Erk et al, 2011; Hafkemeijer et al, 2013; Rodda et al, 2009; Saykin et al, 2006; Scheef et al, 2012; Stewart et al, 2011). These subjective memory assessment results, coupled with our memory strategy selection findings, lend further support for the view that BDNF does not only exerts effects via activity-dependent expression in hippocampal synapses, but also in extra-hippocampal, though memory-relevant regions such as the prefrontal cortex.…”

Section: Discussionmentioning

confidence: 99%

BDNF val66met polymorphism affects aging of multiple types of memory

et al. 2015

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The BDNF val66met polymorphism (rs6265) influences activity-dependent secretion of brain-derived neurotrophic factor in the synapse, which is crucial for learning and memory. Individuals homozygous or heterozygous for the met allele have lower BDNF secretion than val homozygotes and may be at risk for reduced declarative memory performance, but it remains unclear which types of declarative memory may be affected and how aging of memory across the lifespan is impacted by the BDNF val66met polymorphism. This cross-sectional study investigated the effects of BDNF polymorphism on multiple indices of memory (item, associative, prospective, subjective complaints) in a lifespan sample of 116 healthy adults aged 20-93 years. Advancing age showed a negative effect on item, associative and prospective memory, but not on subjective memory complaints. For item and prospective memory, there were significant age x BDNF group interactions, indicating the adverse effect of age on memory performance across the lifespan was much stronger in the BDNF met carriers than for the val homozygotes. BDNF met carriers also endorsed significantly greater subjective memory complaints, regardless of age, and showed a trend (p < .07) toward poorer associative memory performance compared to val homozygotes. These results suggest that genetic predisposition to the availability of brain-derived neurotrophic factor, by way of the BDNF val66met polymorphism, exerts an influence on multiple indices of episodic memory – in some cases in all individuals regardless of age (subjective memory and perhaps associative memory), in others as an exacerbation of age-related differences in memory across the lifespan (item and prospective memory).

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“…Sun et al, 2015), as demonstrated by findings from a recent meta-analysis indicating adults with SDC are twice as likely to develop dementia compared to those without SCD, with annual conversion rates of 2.3% in adults with SCD compared to 1% in those without SCD (Mitchell, Beaumont, Ferguson, Yadegarfar, & Stubbs, 2014). Individuals with SCD also exhibit pathologic markers of AD, such as amyloid-beta and tau protein deposition (Barnes, Schneider, Boyle, Bienias, & Bennett, 2006), regional brain atrophy (Cherbuin, Sargent-Cox, Easteal, Sachdev, & Anstey, 2015; Stewart et al, 2011), and altered brain function (Y. Sun et al, 2015), with evidence of both higher and lower levels of regional cerebral perfusion and metabolism compared to those without SCD.…”

Section: Introductionmentioning

confidence: 99%

Subjective Cognitive Decline Modifies the Relationship Between Cerebral Blood Flow and Memory Function in Cognitively Normal Older Adults

Hays

Zlatar

Campbell

et al. 2017

J Int Neuropsychol Soc

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Objective Subjective cognitive decline (SCD), or self-reported cognitive decline despite normal neuropsychological test performance, is a risk factor for objective cognitive decline and Alzheimer’s disease (AD). While brain mechanisms contributing to SCD are not well defined, studies show associations with vascular risk factors and altered cerebral blood flow (CBF), raising the hypothesis that those with SCD might be experiencing vascular dysregulation, or a disruption in the normal relationship between CBF and cognition. We examined whether the association between CBF and verbal memory performance differs between those with SCD (SCD+) and those without SCD (SCD−). Methods Linear mixed effect models were employed to investigate whether the voxel-wise relationship between arterial spin labeling (ASL) MRI-measured CBF and verbal memory performance was modified by SCD among a group of 70 cognitively normal older adults (35 SCD+, 35 SCD−; mean age=72) matched on age, gender, and symptoms of depression. Results Results indicated that the SCD− group exhibited positive associations between verbal memory and CBF within the posterior cingulate cortex, middle temporal gyrus, and inferior frontal gyrus, whereas the SCD+ group displayed negative associations between verbal memory and CBF within the posterior cingulate cortex, middle temporal gyrus, hippocampus, fusiform gyrus, and inferior frontal gyrus. Conclusions Findings suggest that while higher CBF is supportive of memory function in those without SCD, higher CBF may no longer support memory function in those presenting with SCD, perhaps reflecting neurovascular dysregulation.

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Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study

Cited by 61 publications

References 41 publications

White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

BDNF val66met polymorphism affects aging of multiple types of memory

Subjective Cognitive Decline Modifies the Relationship Between Cerebral Blood Flow and Memory Function in Cognitively Normal Older Adults

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