Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm

Abstract

Con and Riby, Leigh (2015) Hippocampal involvement in glucose facilitation of recognition memory: Event-related potential components in a dual-task paradigm. Nutrition and Aging, 3 (1 Northumbria University has developed Northumbria Research Link (NRL) to enable users to access the University's research output. Copyright © and moral rights for items on NRL are retained by the individual author(s) and/or other copyright owners. Single copies of full items can be reproduced, displayed or performed, and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided the authors, title and full bibliographic details are given, as well as a hyperlink and/or URL to the original metadata page. The content must not be changed in any way. Full items must not be sold commercially in any format or medium without formal permission of the copyright holder. The full policy is available online: http://nrl.northumbria.ac.uk/policies.html This document may differ from the final, published version of the research and has been made available online in accordance with publisher policies. To read and/or cite from the published version of the research, please visit the publisher's website (a subscription may be required.) Nutrition and Aging 3 (2015) METHODS:In this double-blind placebo-controlled cross-over study, 12 older participants (mean age = 69.33 ± 1.69 years) completed the remember-know paradigm both with and without a concurrent tracking task while recording event-related potentials (ERPs). RESULTS: Counter to predictions, glucose reduced overall accuracy. No treatment effects were found for proportion of Remember, Know and Guess responses, although there was a trend towards greater accuracy for 'Remember' responses following glucose. There was weak evidence for dissociation of drink effects on tracking with glucose being associated with preferential allocation of resources to 'Remember' over 'Know' responses. At P3 and F3 electrode sites, a significantly greater left parietal (LP) recollection effect and greater FN400 effect respectively were found for glucose. CONCLUSIONS: These findings do not support task effort modulation of the memory-enhancing effects of glucose. There was evidence of a greater glucose facilitatory effect for hippocampus-mediated LP recollection.

Fuel for Thought? A Systematic Review of Neuroimaging Studies into Glucose Enhancement of Cognitive Performance

“…Six studies were conducted with healthy adult participants (An, Jung, Kim, Lee, & Kim, 2015;Brown & Riby, 2013;Parent et al, 2011;Riby et al, 2008;Serra-Grabulosa, Adan, Falcon, & Bargallo, 2010;Zanchi et al, 2018). Three studies were conducted with healthy elderly samples (Gagnon et al, 2012;Knott, Messier, Mahoney, & Gagnon, 2001;Scholey et al, 2015). One study was conducted with healthy adolescent participants (Smith et al, 2009) and one study was conducted with adults diagnosed with chronic schizophrenia (Stone, Thermenos, Tarbox, Poldrack, & Seidman, 2005).…”

“…Seven of the included studies used Electroencephalography (EEG) as a measure of brain activity, five of these focused on event-related potentials (ERPs: Brown & Riby, 2013;Knott et al, 2001;Riby et al, 2008;Smith et al, 2009;Scholey et al, 2015). Two studies reported spectral analysis of resting EEG (An et al, 2015;Knott et al, 2001).…”

“…In one repeated-measures study, testing pre-and post-ingestion was conducted on the same day (Serra-Grabulosa et al, 2010), in all other studies with repeated-measures, testing of the active and placebo drink occurred on separate days. In seven studies participants were asked to attend the lab after at least eight hours of fasting (usually overnight: An et al, 2015;An et al, 2015;Gagnon et al, 2012;Knott et al, 2001;Parent et al, 2011;Serra-Grabulosa et al, 2010;Scholey et al, 2015;Stone et al, 2005;Zanchi et al, 2018) and in three studies participants were instructed to fast for two hours prior to the testing sessions (Brown & Riby, 2013;Riby et al, 2008;Smith et al, 2009). In ten studies, glucose was administered orally as a drink, in one study the drink was administered via a nasogastric tube (Zanchi et al, 2018).…”

“…The amount of glucose in the active drink was 25 g in four studies (Brown & Riby, 2013;Riby et al, 2008;Scholey et al, 2015), 50 g in four studies (Gagnon et al, 2012;Knott et al, 2001;Parent et al, 2011;Stone et al, 2005), 75 g in two studies (Serra-Grabulosa et al, 2010;Zanchi et al, 2018) and 17 g in one study (An et al, 2015). Seven studies used the non-caloric sweetener saccharine in the placebo condition (Brown & Riby, 2013;Gagnon et al, 2012;Knott et al, 2001;Parent et al, 2011;Riby et al, 2008;Scholey et al, 2015;Stone et al, 2005), while aspartame was used in one (Smith et al, 2009). In two studies baseline testing was conducted without the administration of any reported drink (An et al, 2015;Serra-Grabulosa et al, 2010).…”

Functional Connectivity of the Anterior and Posterior Hippocampus: Differential Effects of Glucose in Younger and Older Adults

“…While cognitive domains implicated in the glucose facilitation effect have been argued to preferentially enhance hippocampusdependent tasks, relatively limited research has directly explored underlying neurophysiological mechanisms in the human brain. Several event-related potential (ERP) studies support the involvement of the hippocampus (Smith et al, 2009;Brown and Riby, 2013;Scholey et al, 2015). Further evidence for the involvement of the hippocampus in the effect stems from a study using fMRI (Parent et al, 2011).…”