Hippocampal lesions and active avoidance

Olton, David S.; Isaacson, Robert L.

doi:10.1016/0031-9384(68)90142-x

Cited by 174 publications

(48 citation statements)

References 18 publications

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“…In addition Alvarez-Palaez (1973) reported that fimbria-fornix damage enhanced the acguisition of a two-way avoidance task. Olton and Isaacson (1968) reported similar results following hippocampal ablation.…”

Section: Possible Neural Mechanisms Involved In the Tuninq-out Processsupporting

confidence: 55%

Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictitating membrane response.

Solomon

1977

Journal of Comparative and Physiological Psychology

469

208

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Section: Possible Neural Mechanisms Involved In the Tuninq-out Processsupporting

confidence: 55%

Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictitating membrane response.

Solomon

1977

Journal of Comparative and Physiological Psychology

469

208

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“…Isaacson [101] extended these findings by showing differential effects of hippocampal aspiration lesion on the acquisition and retention of two types of active avoidance tasks.…”

Section: Electrical Lesionmentioning

confidence: 82%

Roles of the hippocampal formation in pain information processing

2009

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Abstract:Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchicallyinterconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation (HF) in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.

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“…The active avoidance test is an associative learning test (Olton and Isaacson, 1968;Shetty et al, 2013) where mice were placed in an acrylic T-shaped apparatus with black coloured walls and a clear ceiling. The T-shaped apparatus was divided into three compartments, a stem and two goal arms.…”

Section: Active Avoidance Testmentioning

confidence: 99%

The effects of sigma (σ1) receptor‐selective ligands on muscarinic receptor antagonist‐induced cognitive deficits in mice

Malik

Rangel‐Barajas

Sumien

et al. 2015

British J Pharmacology

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BACKGROUND AND PURPOSECognitive deficits in patients with Alzheimer's disease, Parkinson's disease, traumatic brain injury and stroke often involve alterations in cholinergic signalling. Currently available therapeutic drugs provide only symptomatic relief. Therefore, novel therapeutic strategies are needed to retard and/or arrest the progressive loss of memory. EXPERIMENTAL APPROACHScopolamine-induced memory impairment provides a rapid and reversible phenotypic screening paradigm for cognition enhancement drug discovery. Male C57BL/6J mice given scopolamine (1 mg·kg −1 ) were used to evaluate the ability of LS-1-137, a novel sigma (σ1) receptor-selective agonist, to improve the cognitive deficits associated with muscarinic antagonist administration. KEY RESULTSLS-1-137 is a high-affinity (Ki = 3.2 nM) σ1 receptor agonist that is 80-fold selective for σ1, compared with σ2 receptors. LS-1-137 binds with low affinity at D2-like (D2, D3 and D4) dopamine and muscarinic receptors. LS-1-137 was found to partially reverse the learning deficits associated with scopolamine administration using a water maze test and an active avoidance task. LS-1-137 treatment was also found to trigger the release of brain-derived neurotrophic factor from rat astrocytes. CONCLUSIONS AND IMPLICATIONSThe σ1 receptor-selective compound LS-1-137 may represent a novel candidate cognitive enhancer for the treatment of muscarinic receptor-dependent cognitive deficits. AbbreviationsAD, Alzheimer's disease; BDNF, brain-derived neurotrophic factor; BiP, binding immunoglobulin protein; ER, endoplasmic reticulum; PPCC, methyl(1R,2S/1S,2R)-2-[4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopro-panecarboxylate; QNB, quinuclidinyl benzylate IntroductionImpairment in learning and memory is seen in (i) aged populations, (ii) patients with neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease, (iii) stroke patients and (iv) patients with traumatic brain injury (Scarpini et al., 2003;Tarawneh and Galvin, 2010;Ruscher et al., 2011). Although the causes of cognitive impairments vary, previous studies have suggested that alteration in cholinergic neurotransmission may play an important role in the disruption of learning and memory (Francis et al., 1999;Craig et al., 2011;Dumas and Newhouse, 2011). According to the cholinergic hypothesis, age-dependent cognitive decline is primarily related to impairment in cholinergic neurotransmission (Bartus et al., 1982;Coyle et al., 1983;Kirk et al., 1994). Administration of the competitive cholinergic muscarinic receptor antagonist scopolamine causes cognitive dysfunctions similar to those observed in normal aging and AD (Ebert and Kirch, 1998;Bejar et al., 1999;Klinkenberg and Blokland, 2010). A scopolamine-dependent model of cognitive deficits has been used to screen for potential cognition-enhancing drugs (Flood and Cherkin, 1986;Ennaceur and Meliani, 1992;Antonini et al., 2009;Klinkenberg and Blokland, 2010). Since the sigma σ1 receptor is known to potently modulate cho...

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Hippocampal lesions and active avoidance

Cited by 174 publications

References 18 publications

Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictitating membrane response.

Role of the hippocampus in blocking and conditioned inhibition of the rabbit's nictitating membrane response.

Roles of the hippocampal formation in pain information processing

The effects of sigma (σ1) receptor‐selective ligands on muscarinic receptor antagonist‐induced cognitive deficits in mice

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