Hippocampal Magnetization Transfer Ratio at 3T: Validation of Automated Postprocessing and Comparison of Quantification Metrics

Abstract

Excellent scan-rescan reproducibility (ICC > .9, COV < 10%) was observed for specific MTR histogram metrics and the mean MTR approach. These results are comparable to the volumetric approach. Future studies can examine the possibility that MTR changes precede morphological changes as this study suggests that both MTR and volumetric measurements of the hippocampus can be used as reliable imaging tools.