Hippocampal monoamine receptor complex levels linked to spatial memory decline in the aging C57BL/6J

Saroja, Sivaprakasam R.; Kim, Eunjung; Shanmugasundaram, Bharanidharan; Höger, Harald; Lubec, Gert

doi:10.1016/j.bbr.2014.01.042

Cited by 17 publications

(14 citation statements)

References 55 publications

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“…Dopamine increases hippocampal rat neurogenesis and, vice versa, its depletion decreases NPC proliferation [27]. VTA dopaminergic neurons and hippocampal dopamine receptor 1 (DR1) and DR2 decrease with age in mice [43]. …”

Section: Age-related Changes Affecting Neurogenesismentioning

confidence: 99%

Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review

Seib

Martín-Villalba²

2014

Gerontology

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New neurons are continuously generated and added to neural circuits in the adult brain. However, increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis. Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associated with memory impairments. Several mechanisms are known that might counteract this decline in cognitive functions. Here, we give an overview of ageing-related changes in neurogenesis in the brain of humans and rodents. We discuss possible causes for reduced neurogenesis with age, its consequences on cognition, and how neurogenesis might be restored in old age.

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Section: Age-related Changes Affecting Neurogenesismentioning

confidence: 99%

Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review

Seib

Martín-Villalba²

2014

Gerontology

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“…For instance, the time-course (0–120 h) of autoshaped responses revealed progressive performance and mRNA 5-HT 1A or 5-HT 7 receptors are monotonically augmented or declined in prefrontal cortex, hippocampus and raphe nuclei, respectively (Perez-Garcia and Meneses, 2009). Moreover, 5-HT 1A receptor is increased, whereas 5-HT 7 receptor levels are decreased by aging (Saroja et al, 2014). Also, they showed significant correlation with the time spent in target quadrant; hence according with Saroja et al (2014) these are two key parameter of memory retrieval which in turn unambiguously links the serotonergic receptor system to spatial memory performance.…”

Section: -Ht7 Receptor Stimulationmentioning

confidence: 99%

“…Moreover, 5-HT 1A receptor is increased, whereas 5-HT 7 receptor levels are decreased by aging (Saroja et al, 2014). Also, they showed significant correlation with the time spent in target quadrant; hence according with Saroja et al (2014) these are two key parameter of memory retrieval which in turn unambiguously links the serotonergic receptor system to spatial memory performance.…”

Section: -Ht7 Receptor Stimulationmentioning

confidence: 99%

5-HT7 receptor stimulation and blockade: a therapeutic paradox about memory formation and amnesia

Meneses

2014

Front. Behav. Neurosci.

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“…All procedures were performed at 4°C as published previously (Saroja et al, ). The extracted membrane receptor proteins were then aliquoted and stored at −80°C until use.…”

Section: Methodsmentioning

confidence: 99%

“…Homogenization, sample preparation, and extraction of membrane proteins All procedures were performed at 48C as published previously (Saroja et al, 2014). The extracted membrane receptor proteins were then aliquoted and stored at 2808C until use.…”

Section: Biochemical Analysesmentioning

confidence: 99%

Individual phases of contextual fear conditioning differentially modulate dorsal and ventral hippocampal GluA1-3, GluN1-containing receptor complexes and subunits

Sase

Sialana

et al. 2015

Hippocampus

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In contextual fear conditioning (CFC), the use of pharmacological and lesion approaches has helped to understand that there are differential roles for the dorsal hippocampus (DH) and the ventral hippocampus (VH) in the acquisition, consolidation and retrieval phases. Concomitant analysis of the DH and the VH in individual phases with respect to α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors and N-methyl-D-aspartate receptor subtype N1 (GluN1)-containing complexes (RCC) and subunits has not been reported so far. Herein, CFC was performed in mice that were euthanized at different time points. DH and VH samples were taken for the determination of RCC and subunit levels using BN- and SDS-PAGE, respectively, with subsequent Western blotting. Evaluation of spine densities, morphology, and immunohistochemistry of GluA1 and GluA2 was performed. In the acquisition phase levels of GluA1-RCC and subunits in VH were increased. In the consolidation phase GluA1- and GluA2-RCC levels were increased in DH and VH, while both receptor subunit levels were increased in the VH only. In the retrieval phase GluA1-RCC, subunits thereof and GluA2-RCC were increased in DH and VH, whereas GluA2 subunits were increased in the VH only. GluN1-RCC levels were increased in acquisition and consolidation phase, while subunit levels in the acquisition phase were increased only in the DH. The immunohistochemical studies in the individual phases in subareas of hippocampus supported immunochemical changes of GluA1 and GluA2 RCC's. Dendritic spine densities and the prevalence of thin spines in the acquisition phase of VH and mushroom spines in the retrieval phase of the VH and DH were increased. The findings from the current study suggest different receptor and receptor complex patterns in the individual phases in CFC and in DH and VH. The results propose that different RCCs are formed in the individual phases and that VH and DH may be involved in CFC.

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Hippocampal monoamine receptor complex levels linked to spatial memory decline in the aging C57BL/6J

Cited by 17 publications

References 55 publications

Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review

Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review

5-HT7 receptor stimulation and blockade: a therapeutic paradox about memory formation and amnesia

Individual phases of contextual fear conditioning differentially modulate dorsal and ventral hippocampal GluA1-3, GluN1-containing receptor complexes and subunits

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