Hippocampal resting-state functional connectivity with the mPFC and DLPFC moderates and mediates the association between education level and memory function in subjective cognitive decline

Xu, Shurui; Sun, Qianqian; Li, Ming; Luo, Jia; Cai, Guiyan; Chen, Ruilin; Zhang, Lin; Liu, Jiao

doi:10.26599/bsa.2021.9050013

Cited by 4 publications

(5 citation statements)

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“…The observed fluctuations in network topology during the break were likely to be directly related to ongoing cognitive processing (Shine and Poldrack, 2018). The current research on RSNs showed that the functional couplings between regions at resting state contained information relevant to cognition, perception, and behavior (Sadaghiani and Kleinschmidt, 2013), rather than simply reflecting an invariant structural anatomy, historical coactivation patterns, or internal dynamics of local areas; the intrinsic activity predicted subsequent perceptual processing (van den Berg et al, 2016;Xu et al, 2021).…”

Section: The High Synchrony Of the Resting State High-order Cognitive...mentioning

confidence: 70%

The Task Pre-Configuration Is Associated With Cognitive Performance Evidence From the Brain Synchrony

Xiang

Fan

Wei

et al. 2022

Front. Comput. Neurosci.

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Although many resting state and task state characteristics have been studied, it is still unclear how the brain network switches from the resting state during tasks. The current theory shows that the brain is a complex dynamic system and synchrony is defined to measure brain activity. The study compared the changes of synchrony between the resting state and different task states in healthy young participants (N = 954). It also examined the ability to switch from the resting state to the task-general architecture of synchrony. We found that the synchrony increased significantly during the tasks. And the results showed that the brain has a task-general architecture of synchrony during different tasks. The main feature of task-based reasoning is that the increase in synchrony of high-order cognitive networks is significant, while the increase in synchrony of sensorimotor networks is relatively low. In addition, the high synchrony of high-order cognitive networks in the resting state can promote task switching effectively and the pre-configured participants have better cognitive performance, which shows that spontaneous brain activity and cognitive ability are closely related. These results revealed changes in the brain network configuration for switching between the resting state and task state, highlighting the consistent changes in the brain network between different tasks. Also, there was an important relationship between the switching ability and the cognitive performance.

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Section: The High Synchrony Of the Resting State High-order Cognitive...mentioning

confidence: 70%

The Task Pre-Configuration Is Associated With Cognitive Performance Evidence From the Brain Synchrony

Xiang

Fan

Wei

et al. 2022

Front. Comput. Neurosci.

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“…Neuroimaging studies of episodic memory have long shown prefrontal activity associated with episodic retrieval [1,78,79]. The DLPFC has been associated with different aspects of retrieval including being in a retrieval mode [80][81][82], post-retrieval monitoring and evaluation [20,[83][84][85][86], general decision operations [87][88][89], and control-related modulation of the hippocampus [90][91][92]. Much of the fMRI work focusing on understanding the role of the PFC in retrieval has examined the right DLPFC because it showed more robust activation in earlier studies [1,[13][14][15][16][17]80,81], but a meta-analysis of fMRI studies of episodic memory also show the left DLPFC has a role [93].…”

Section: Episodic Memory and The Role Of The Left And Right Prefronta...mentioning

confidence: 99%

Lack of effects of online HD-tDCS over the left or right DLPFC in an associative memory and metamemory monitoring task

Imperio,

Chua

2024

PLoS ONE

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Neuroimaging studies have shown that activity in the prefrontal cortex correlates with two critical aspects of normal memory functioning: retrieval of episodic memories and subjective “feelings-of-knowing" about our memory. Brain stimulation can be used to test the causal role of the prefrontal cortex in these processes, and whether the role differs for the left versus right prefrontal cortex. We compared the effects of online High-Definition transcranial Direct Current Stimulation (HD-tDCS) over the left or right dorsolateral prefrontal cortex (DLPFC) compared to sham during a proverb-name associative memory and feeling-of-knowing task. There were no significant effects of HD-tDCS on either associative recognition or feeling-of-knowing performance, with Bayesian analyses showing moderate support for the null hypotheses. Despite past work showing effects of HD-tDCS on other memory and feeling-of-knowing tasks, and neuroimaging showing effects with similar tasks, these findings add to the literature of non-significant effects with tDCS. This work highlights the need to better understand factors that determine the effectiveness of tDCS, especially if tDCS is to have a successful future as a clinical intervention.

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“…A previous study has proved that the apolipoprotein E (APOE) ε4 allele is a genetic risk factor for AD, whereas educational attainments have protective effects against cognitive decline in aging and patients with AD (Li et al, 2021 ). Thus, the progression from SCD to MCI and AD may need multidimensional analyses, such as clinical cognitive scales (Tabatabaei-Jafari et al, 2018 ), education level (Xu et al, 2021 ), structural indexes (Moore et al, 2018 ), functional indexes (Sun et al, 2016 ), cerebrospinal fluid (Hays et al, 2018 ), and cortical glucose metabolism measured by positron emission tomography (PET) (Eliassen et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Dynamic Functional Networks in Subjective Cognitive Decline and Alzheimer's Disease

Wang

Liu

et al. 2022

Front. Comput. Neurosci.

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Subjective cognitive decline (SCD) is considered to be the preclinical stage of Alzheimer's disease (AD) and has the potential for the early diagnosis and intervention of AD. It was implicated that CSF-tau, which increases very early in the disease process in AD, has a high sensitivity and specificity to differentiate AD from normal aging, and the highly connected brain regions behaved more tau burden in patients with AD. Thus, a highly connected state measured by dynamic functional connectivity may serve as the early changes of AD. In this study, forty-five normal controls (NC), thirty-six individuals with SCD, and thirty-five patients with AD were enrolled to obtain the resting-state functional magnetic resonance imaging scanning. Sliding windows, Pearson correlation, and clustering analysis were combined to investigate the different levels of information transformation states. Three states, namely, the low state, the middle state, and the high state, were characterized based on the strength of functional connectivity between each pair of brain regions. For the global dynamic functional connectivity analysis, statistically significant differences were found among groups in the three states, and the functional connectivity in the middle state was positively correlated with cognitive scales. Furthermore, the whole brain was parcellated into four networks, namely, default mode network (DMN), cognitive control network (CCN), sensorimotor network (SMN), and occipital-cerebellum network (OCN). For the local network analysis, statistically significant differences in CCN for low state and SMN for middle state and high state were found in normal controls and patients with AD. Meanwhile, the differences were also found in normal controls and individuals with SCD. In addition, the functional connectivity in SMN for high state was positively correlated with cognitive scales. Converging results showed the changes in dynamic functional states in individuals with SCD and patients with AD. In addition, the changes were mainly in the high strength of the functional connectivity state.

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Hippocampal resting-state functional connectivity with the mPFC and DLPFC moderates and mediates the association between education level and memory function in subjective cognitive decline

Cited by 4 publications

References 58 publications

The Task Pre-Configuration Is Associated With Cognitive Performance Evidence From the Brain Synchrony

The Task Pre-Configuration Is Associated With Cognitive Performance Evidence From the Brain Synchrony

Lack of effects of online HD-tDCS over the left or right DLPFC in an associative memory and metamemory monitoring task

Abnormal Dynamic Functional Networks in Subjective Cognitive Decline and Alzheimer's Disease

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