Hippocampal theta rhythm after local administration of procaine or amphetamine into the ventral tegmental area in fear conditioned rats

Matulewicz, Paweł; Orzeł-Gryglewska, Jolanta; Braszka, Łukasz; Zawistowski, Piotr; Jurkowlaniec, E

doi:10.1016/j.neulet.2015.01.049

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…At the same time, cholinergic innervation powerfully modulates hippocampal theta oscillation power and coherence (Hasselmo 2006; Vandecasteele et al 2014). Also, inactivation of the ventral tegmental area with procaine in rats leads to impaired fear conditioning and decreased θ power of CA1 specifically at the Lθ frequency range (3–6 Hz) during immobility states, whereas control rats exhibit an increases in θ power after fear conditioning (Matulewicz et al 2015). Therefore, we speculate that interfering with increase of Lθ may impair learning and/or retrieval of context memories or, as our data suggest, introduce an error in discrimination of 2 similar but yet different contexts.…”

Section: Discussionmentioning

confidence: 99%

Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination

et al. 2017

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Heparan sulfate (HS) proteoglycans represent a major component of the extracellular matrix and are critical for brain development. However, their function in the mature brain remains to be characterized. Here, acute enzymatic digestion of HS side chains was used to uncover how HSs support hippocampal function in vitro and in vivo. We found that long-term potentiation (LTP) of synaptic transmission at CA3–CA1 Schaffer collateral synapses was impaired after removal of highly sulfated HSs with heparinase 1. This reduction was associated with decreased Ca2+ influx during LTP induction, which was the consequence of a reduced excitability of CA1 pyramidal neurons. At the subcellular level, heparinase treatment resulted in reorganization of the distal axon initial segment, as detected by a reduction in ankyrin G expression. In vivo, digestion of HSs impaired context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, HSs maintain neuronal excitability and, as a consequence, support synaptic plasticity and learning.

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Section: Discussionmentioning

confidence: 99%

Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination

et al. 2017

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“…In a recent research, it has been pointed out that procaine injection into the ventral segmental area is able to suppress temporarily the fear conditioned avoidance response in rats and also acts on hippocampus theta rhythms which are related with arousal and attention [72]. Apparently, the metabolites of Procaine are responsible for the additional pharmacologic actions.…”

Section: The Procaine-infusion -The Logic Following Of Other Parenteral Applicationsmentioning

confidence: 99%

Procaine and Procaine-Base-Infusion: A Review of the Safety and Fields of Application after Twenty Years of Use

Urm¹,

Oettmeier²,

Nazlıkul³

2018

Clin Res Open Access

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The highly-dosed infusion with Procaine-HCl with sodium-bicarbonate as additive was firstly published twenty years ago. The method advanced to a routine in many centers for pain treatment, rehabilitation and natural medicine. The aim of the procedure is the systemic use of the various pharmacological features of Procaine, especially to inhibit pain and inflammation, for vasodilatation, anti-oxidation and to harmonize the vegetative nervous system. The addition of sodium-bicarbonate balances the common latent pH-decrease in the periphery. The degradation products of Procaine, diethylaminoethanol (DEAE) and para-amino benzoic acid (PABA), have a systemic effect. For the safety of the patients after 500.000 applications: the procaine-infusion is safe. To improve the success rate of the method of the classic Procaine-Base-infusion should be realized an acid-base-diagnostic.

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“…In a recent research, it has been pointed out that procaine injection into the ventral tegmental area is able to suppress temporarily the fear conditioned avoidance response in rats and also acts on hippocampal theta rhythms which are related with arousal and attention [57]. Apparently, the metabolites of Procaine are responsible for the additional pharmacologic actions.…”

Section: The Procaine-infusion -The Logic Following Of Other Parentermentioning

confidence: 99%

The Procaine-Base-Infusion: a Review after twenty Years of Use

Oettmeier¹,

Reuter²

2017

J Med - Clin Res & Rev

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The highly-dosed infusion with Procaine-HCl with sodium-bicarbonate as additive was firstly published twenty years ago. The method advanced to a routine in many centers for pain treatment, rehabilitation and natural medicine. The aim of the procedure is the systemic use of the various pharmacological features of Procaine, especially to inhibit pain and inflammation, for vasodilatation, anti-oxidation and to harmonize the vegetative nervous system. On one hand shall the addition of sodium-bicarbonate balance the common latent pH-decrease in the periphery. On the other hand also the degradation products of Procaine (DAE and PABA) have a systemic effect. For the safety of the patients and to improve the success rate of the method it was shown that the classic Procaine-Base-infusion should be only realized on the base of a prior acid-base-diagnostic.

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Hippocampal theta rhythm after local administration of procaine or amphetamine into the ventral tegmental area in fear conditioned rats

Cited by 6 publications

References 37 publications

Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination

Heparan Sulfates Support Pyramidal Cell Excitability, Synaptic Plasticity, and Context Discrimination

Procaine and Procaine-Base-Infusion: A Review of the Safety and Fields of Application after Twenty Years of Use

The Procaine-Base-Infusion: a Review after twenty Years of Use

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