Hippuric Acid and an Unidentified Compound as Possible Indicators of Residual Renal Function in Dialyzed Patients

Schoots, A.C.; Vanholder, Raymond; Gladdines, MM Marcel; Smet, Rita De; Cramers, C.A.M.G.; Ringoir, S

doi:10.1159/000412452

Cited by 3 publications

(3 citation statements)

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“…Our findings are important within the context of the search for accurate markers of uremic toxicity, since in earlier studies a significant correlation has been found between free hippuric acid concentration in serum and residual renal function [3] and the overall retention of UV-absorbing solutes [1,2]. It has also been shown that hippuric acid interferes with drug protein binding [7,8], organic anion transport [9], and glucose tolerance [10].…”

Section: Discussionmentioning

confidence: 70%

“…It has recently been demonstrated that hippuric acid concentrations give a relevant estimate of uremic solute retention in terminal renal failure [1,2] and of residual renal function [3], Since these studies have all been per formed using high-performance liquid chromatography (HPLC), the question arises whether there is a less com plex method for the determination of hippurate concen tration and to what extent the results and information obtained by such a method would be comparable with those obtained using HPLC. A less complicated method that has been used, for hippuric acid concentration mea surement, is the colorimetric method, described by Ohmori et al [4], The present study was undertaken to compare the concentration of total and free hippuric acid when determined on the same in vivo uremic serum samples, by both HPLC and the colorimetric method.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of a Colorimetric and a HPLC Method for the Determination of Serum Hippuric Acid Concentrations in Uremia

Vanholder

Smet²,

Schoots³

et al. 1988

Nephron

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Hippuric acid has been recognized as a potential marker of uremic toxicity in chronic renal failure. However, in most studies, serum hippuric acid concentrations have been determined by sophisticated methods, such as high-performance liquid chromatography. The present study was undertaken to evaluate whether the less complicated colorimetric determination method could replace such methods. Based on 21 different samples, the results obtained by both methods appeared to be correlated to each other in a highly significant way (total hippuric acid: r = 0.99, p < 0.001; free hippuric acid; r = 1.00, p < 0.001). Mean total and free hippuric acid concentrations and mean percent protein binding, obtained with both determination methods, were also identical. It is concluded that both the colorimetric method and high-performance liquid chromatography are equally reliable for the study of the concentration of hippuric acid in uremic serum and of its importance as a marker of the clinical and biochemical epiphenomena of uremic toxicity.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Correlation of a Colorimetric and a HPLC Method for the Determination of Serum Hippuric Acid Concentrations in Uremia

Vanholder

Smet²,

Schoots³

et al. 1988

Nephron

Self Cite

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“…Also, from a theoretical point of view, the equivalency concept is debatable because renal function includes not only glomerular filtration, but also tubular secretion and reabsorption, as well as various endocrine functions. Tubular secretion is especially important for the removal of organic acids such as hippuric acid, the plasma concentration of which is directly correlated to residual creatinine clearance in hemodialysis patients (16). The importance of tubular secretion in the removal of organic acids was also evident in the study by van Olden et al (17).…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Kt/V_Urea and Npna in Anuric Peritoneal Dialysis Patients: A Comparison with Predialysis Patients

Jansen

Korevaar²,

Dekker

et al. 2001

Perit Dial Int

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Objective It is unknown whether a given level of urea clearance by the native kidneys provides better or similar control of uremia than the same level of urea clearance by continuous peritoneal dialysis (PD). More insight into possible differences between renal and peritoneal urea clearances is warranted. Therefore, we investigated the relationship between Kt/Vurea and protein equivalent of total nitrogen appearance normalized to body weight (nPNA), the relationship between urea clearance and creatinine appearance, and other nutritional parameters in PD patients without residual renal function, and in predialysis end-stage renal disease patients. Patients All patients participated in the Netherlands Cooperative Study on the Adequacy of Dialysis. This is a prospective cohort study of incident dialysis patients, in whom regular assessments of renal function are done. A group of 75 PD patients was identified at the first follow-up assessment in which their urine production was less than 100 mL/day. These patients were considered the anuric group. This group was compared with a control group of 97 predialysis patients studied 0 – 4 weeks before the start of dialysis treatment. Results Linear relationships were present between Kt/Vurea and nPNA, in both the predialysis patients and the anuric PD patients. A significant difference was present between the slopes of the two regression lines (0.40 vs 0.18, p = 0.007). When Kt/Vurea exceeded 1.3/week, a given level of Kt/Vurea was associated with a higher nPNA in predialysis than in anuric PD patients. Similar relationships were found between Kturea and PNA. Kturea was also significantly related to urine or dialysate creatinine appearance. A significant difference existed between the slopes of the regression lines in the two groups of patients ( p < 0.001). A weekly Kturea of 70 L was associated with a urine creatinine appearance of 11.0 mmol/day and a dialysate creatinine appearance of 8.4 mmol/day. Nutritional status measured with creatinine appearance and Subjective Global Assessment was better in the predialysis population, despite much lower values for Kt/Vurea in these patients. Conclusions The relationship between Kt/Vurea and nPNA in anuric PD patients is different from that in a predialysis population. It follows from our results that, when Kt/Vurea is above 1.3/week, a given level of Kt/Vurea is associated with a higher nPNA in predialysis than in anuric PD patients. This challenges the concept of equivalency between renal and peritoneal Kt/Vurea with respect to control of uremic morbidity.

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A case report of acute thinner poisoning complicated by acute renal dysfunction on admission.

Tanaka

Ohkura

Tajimi

et al. 1999

Nihon Shuchu Chiryo Igakukai zasshi J Jpn Soc Intensive Care Me

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Hippuric Acid and an Unidentified Compound as Possible Indicators of Residual Renal Function in Dialyzed Patients

Cited by 3 publications

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Correlation of a Colorimetric and a HPLC Method for the Determination of Serum Hippuric Acid Concentrations in Uremia

Correlation of a Colorimetric and a HPLC Method for the Determination of Serum Hippuric Acid Concentrations in Uremia

The Relationship between Kt/V_Urea and Npna in Anuric Peritoneal Dialysis Patients: A Comparison with Predialysis Patients

A case report of acute thinner poisoning complicated by acute renal dysfunction on admission.

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Hippuric Acid and an Unidentified Compound as Possible Indicators of Residual Renal Function in Dialyzed Patients

Cited by 3 publications

References 0 publications

Correlation of a Colorimetric and a HPLC Method for the Determination of Serum Hippuric Acid Concentrations in Uremia

Correlation of a Colorimetric and a HPLC Method for the Determination of Serum Hippuric Acid Concentrations in Uremia

The Relationship between Kt/VUrea and Npna in Anuric Peritoneal Dialysis Patients: A Comparison with Predialysis Patients

A case report of acute thinner poisoning complicated by acute renal dysfunction on admission.

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Product

Resources

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The Relationship between Kt/V_Urea and Npna in Anuric Peritoneal Dialysis Patients: A Comparison with Predialysis Patients