Histamine and 5-Hydroxytryptamine in the Blood of Infants and Children

Mitchell, Robert J.; Cass, Rosemary

doi:10.1172/jci103837

Cited by 52 publications

(33 citation statements)

References 25 publications

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“…There does not appear to be any defective uptake of 5HT by platelets deriving from cord blood (Stacey, 1965), despite a limited experiment implying the contrary by Mitchell and Cass (1959). Enhanced breakdown of 5HT, though theoretically possible, is unlikely, for monoamine oxidase, the enzyme largely responsible for its inactivation, is decreased during the newborn period both in the human (Epps, 1945) and in the rat (Shimizu and Morikawa, 1959;Nachmias, 1960;Karki, Kuntzman, and Brodie, 1962). Endogenous release of 5HT from viable platelets has never been demonstrated under physiological conditions, though some exchange of radio-isotopically labelled amine has been noted in patients with the carcinoid syndrome (Zucker, Hellman, and Zumoff, 1964), and alkaline extracts of various tissues can provoke such release in vitro (Toh, 1956;Giarman, Potter, and Day, 1960).…”

Section: Discussionmentioning

confidence: 89%

“…In certain experimental animals, brain 5HT levels are low at birth (Kato, 1960;Nachmias, 1960;Karki et al, 1962;Smith, Stacey, and Young, 1962;Hsia, Nishimura, and Brenchley, 1963), though there is some species variation (Pepeu and Giarman, 1962). If this finding can be extrapolated to man, there exists the likelihood of defective synthesis of 5HT in early life.…”

Section: Discussionmentioning

confidence: 99%

“…Taking the difference of method into account, values determined by Mitchell and Cass (1959) in umbilical venous blood (12 ± 12 m,ug./ml.) are not dissimilar from those described here.…”

Section: Discussionmentioning

confidence: 99%

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Blood 5-hydroxytryptamine levels in the newborn.

Hazra¹,

Benson²,

Sandler³

1965

Archives of Disease in Childhood

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During the course of a long-term investigation, still in progress, designed to shed light on the observation of Pare, Sandler, and Stacey (1960) that certain children with mental handicap have high blood 5-hydroxytryptamine (5HT) concentrations, some data on levels in normal newborn infants were obtained which seem to be worthy of record. MethodWhole-blood 5HT levels were measured by the method of Contractor (1964) with the following modifications. (a) Capillary blood obtained from the heel with minimal squeezing was used instead of venous blood. It had previously been established in four normal adults that 5HT levels in capillary and venous blood drawn simultaneously were in close agreement. (b) The procedure was scaled down to allow the use of 1 ml. blood instead of 2 ml. and carboxymethylcellulose columns were reduced in height from 10 to 5 cm. These changes inevitably reduced the sensitivity of the procedure and increased the error of the method from ± 5 % to ± 36%, but as the observed changes in blood levels in each age-group were greater than this margin of error, they were considered to be significant.Platelets were counted by the method of Dacie and Lewis (1963). ResultsSamples of capillary blood were taken from normal full-term infants at 1 day and 1 week of life * Present address:

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Blood 5-hydroxytryptamine levels in the newborn.

Hazra¹,

Benson²,

Sandler³

1965

Archives of Disease in Childhood

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“…Mitchell & Cass (1959) found slightly elevated levels of histamine in blood from the umbilical vein (one case in ten was above 100 ng/ml). Subsequently Bjurd.…”

Section: Introductionmentioning

confidence: 92%

Histamine and granulocytes in the umbilical cord blood of infants at birth

Mitchell

Porter

1970

British J Pharmacology

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Summary Histamine levels in whole blood and plasma from the umbilical arteries and veins, together with circulating basophil and eosinophil counts, were determined in two groups of healthy infants, “term” and “pre‐term”. No significant arteriovenous differences were found except in the basophil counts of the “pre‐term” group. This result was consistent with the finding of significant arteriovenous correlations for all these sets of estimations except the basophil counts in the “pre‐term” group. No significant differences were found between the mean values in either group except for the difference between the mean basophil counts for venous blood. Plasma histamine levels (arterial and venous) were usually less than the lowest limit of the method (1.8 ng/ml). Very small amounts of histamine were detected, however, in one venous and one arterial specimen in the “pre‐term” group, but these did not produce a significant difference between the levels for the two groups of infants.

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“…Electrocardiogram, electromyogram, and radiographs of the chest and skull were normal. In normal children, the serotonin level (Hazra, Benson, and Sandler, 1965;Mitchell, and Cass, 1959) and the urinary excretion of 5-hydroxyindoleacetic acid (Serra, 1958;Rappallini and Murtagh, 1962) approach adult values between 6 weeks and 4 months of age.…”

mentioning

confidence: 99%