Histamine in the Crosstalk Between Innate Immune Cells and Neurons: Relevance for Brain Homeostasis and Disease

Bernardino, Liliana

doi:10.1007/7854_2021_235

Cited by 7 publications

(5 citation statements)

References 151 publications

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“…Histamine is known to exert a regulator, pro-inflammatory immune responses triggered by monocytes, including macrophages (Bernardino, 2021). In this study, famotidine's reduction in the accumulation of mononuclear cells suggests that famotidine has an inhibitory effect on inflammation of the airways, likely attributable to the decreased presence of mononuclear cells and the subsequent decrease in inflammatory molecules and cytokines that are produced by these cells.…”

Section: Discussionmentioning

confidence: 60%

An Investigation of Anti-inflammatory Effects of Famotidine in Rats by Evaluating Inflammatory Cells and Lung Histopathology: An Airway Model

Ali Hasan,

Abdulkhaliq Ibrahim

2023

JAHP

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P ersistent respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD) remain significant global challenges for individuals and healthcare systems due to respiratory complications, prolonged hospitalization, and heightened mortality risks (Liccardi et al., 2012). Typically, asthma involves immune system activation, leukocytes infiltration, excessive mucus production, and remodeling of the airways (Boonpiyathad et al., 2019, Athari, 2019. Moreover, COPD has emerged as a significant contributor to mortality and has been classified as the third leading cause of death worldwide (Sritharan et al., 2021, Lee andSin, 2022). Individuals with COPD face a heightened risk of infection, lung cancer, and sudden occurrences of acute pulmonary embolism (Lopez-Campos et al., 2014, Patel andPriefer, 2022).

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Section: Discussionmentioning

confidence: 60%

An Investigation of Anti-inflammatory Effects of Famotidine in Rats by Evaluating Inflammatory Cells and Lung Histopathology: An Airway Model

Ali Hasan,

Abdulkhaliq Ibrahim

2023

JAHP

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“…The content of Mast cells and HLA was different between pd samples and normal samples. Some studies have shown that histamine can regulate microglia and peripheral circulating monocytes in the brain to induce innate immune response and participate in the pathogenesis of Parkinson’s disease 31 . Other studies have shown that the activation of IFN- γ may be a potential link between Parkinson's disease and inflammation and neurodegeneration 32 , 33 .…”

Section: Discussionmentioning

confidence: 99%

Identification of Parkinson’s disease-associated chromatin regulators

Xing

Wang

2023

Sci Rep

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Parkinson’s disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments can significantly improve patients’ quality of life. There is growing evidence that chromatin regulatory proteins (CRs) are involved in a variety of biological processes, including inflammation, apoptosis, autophagy, and proliferation. But the relationship of chromatin regulators in Parkinson’s disease has not been studied. Therefore, we aim to investigate the role of CRs in the pathogenesis of Parkinson’s disease. We collected 870 chromatin regulatory factors from previous studies and downloaded data on patients with PD from the GEO database. 64 differentially expressed genes were screened, the interaction network was constructed and the key genes with the top 20 scores were calculated. Then we discussed its correlation with the immune function of PD. Finally, we screened potential drugs and miRNAs. Five genes related to the immune function of PD, BANF1, PCGF5, WDR5, RYBP and BRD2, were obtained by using the absolute value of correlation greater than 0.4. And the disease prediction model showed good predictive efficiency. We also screened 10 related drugs and 12 related miRNAs, which provided a reference for the treatment of PD. BANF1, PCGF5, WDR5, RYBP and BRD2 are related to the immune process of Parkinson’s disease and can predict the occurrence of Parkinson’s disease, which is expected to become a new target for the diagnosis and treatment of Parkinson’s disease.

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“…Neuroinflammation in PD, characterized by microglial activation, contributes to dopaminergic neuron degeneration and disease progression [ 108 ]. Notably, the substantia nigra exhibits higher microglial density than other brain regions, increasing the vulnerability of dopaminergic neurons to external immune stimuli.…”

Section: Microglial Hcn Channel Involved In Pd Neuroinflammationmentioning

confidence: 99%

“…Notably, the substantia nigra exhibits higher microglial density than other brain regions, increasing the vulnerability of dopaminergic neurons to external immune stimuli. Furthermore, systemic or intracerebral lipopolysaccharide injections significantly increase microglial proliferation and decrease the number of tyrosine hydroxylase-positive neurons in the substantia nigra [ 108 ].…”

Section: Microglial Hcn Channel Involved In Pd Neuroinflammationmentioning

confidence: 99%

Role of HCN channels in the functions of basal ganglia and Parkinson’s disease

Qi,

Yan,

Fan

et al. 2024

Cell. Mol. Life Sci.

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Parkinson's disease (PD) is a motor disorder resulting from dopaminergic neuron degeneration in the substantia nigra caused by age, genetics, and environment. The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a member of the HCN1-4 gene family and is widely expressed in basal ganglia nuclei. The hyperpolarization-activated current mediated by the HCN channel has a distinct impact on neuronal excitability and rhythmic activity associated with PD pathogenesis, as it affects the firing activity, including both firing rate and firing pattern, of neurons in the basal ganglia nuclei. This review aims to comprehensively understand the characteristics of HCN channels by summarizing their regulatory role in neuronal firing activity of the basal ganglia nuclei. Furthermore, the distribution and characteristics of HCN channels in each nucleus of the basal ganglia group and their effect on PD symptoms through modulating neuronal electrical activity are discussed. Since the roles of the substantia nigra pars compacta and reticulata, as well as globus pallidus externus and internus, are distinct in the basal ganglia circuit, they are individually described. Lastly, this investigation briefly highlights that the HCN channel expressed on microglia plays a role in the pathological process of PD by affecting the neuroinflammatory response.

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Histamine in the Crosstalk Between Innate Immune Cells and Neurons: Relevance for Brain Homeostasis and Disease

Cited by 7 publications

References 151 publications

An Investigation of Anti-inflammatory Effects of Famotidine in Rats by Evaluating Inflammatory Cells and Lung Histopathology: An Airway Model

An Investigation of Anti-inflammatory Effects of Famotidine in Rats by Evaluating Inflammatory Cells and Lung Histopathology: An Airway Model

Identification of Parkinson’s disease-associated chromatin regulators

Role of HCN channels in the functions of basal ganglia and Parkinson’s disease

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