Histamine is required during neural stem cell proliferation to increase neuron differentiation

Rodríguez‐Martínez, Griselda; Velasco, Iván; García‐López, Guadalupe; Solís, K.H.; Flores‐Herrera, Héctor; Díaz, N.F.; Molina‐Hernández, Anayansí

doi:10.1016/j.neuroscience.2012.04.049

Cited by 37 publications

(39 citation statements)

References 44 publications

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“…Interestingly, histamine increased the number of BrdU+DCX+ and Ki67+DCX+ cells but did not significantly affected the population of BrdU+DCX− or Ki67+DCX− cells. Altogether, these data indicate that histamine does not induce an overall increase of cell proliferation in the SVZ, but instead may trigger neuronal commitment (as previously showed by us—Bernardino et al, 2012) and/or induce neuroblast proliferation as previously reported (Rodríguez-Martínez et al, 2012; Molina-Hernández et al, 2013). …”

Section: Introductionsupporting

confidence: 85%

“…Recently, it was shown that histamine has a strong proneurogenic effect in neonatal SVZ (Bernardino et al, 2012) and in embryonic cortical cell cultures (Molina-Hernández and Velasco, 2008; Rodríguez-Martínez et al, 2012; Molina-Hernández et al, 2013) via H1R activation. Histamine may trigger increased transcription of FGFR1 and increased cell proliferation culminating in the differentiation of FOXP2 neuronal cells both in vitro and in vivo (Rodríguez-Martínez et al, 2012; Molina-Hernández et al, 2013) (Figure S1A).…”

Section: Introductionmentioning

confidence: 99%

“…Histamine may trigger increased transcription of FGFR1 and increased cell proliferation culminating in the differentiation of FOXP2 neuronal cells both in vitro and in vivo (Rodríguez-Martínez et al, 2012; Molina-Hernández et al, 2013) (Figure S1A). We also showed that histamine induces an increase of the expression of Mash1, Dlx2 and Ngn1 proneurogenic genes and ultimately favors the GABAergic neuronal phenotype.…”

Section: Introductionmentioning

confidence: 99%

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New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis

et al. 2014

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The subventricular zone (SVZ) contains neural stem cells (NSCs) that generate new neurons throughout life. Many brain diseases stimulate NSCs proliferation, neuronal differentiation and homing of these newborns cells into damaged regions. However, complete cell replacement has never been fully achieved. Hence, the identification of proneurogenic factors crucial for stem cell-based therapies will have an impact in brain repair. Histamine, a neurotransmitter and immune mediator, has been recently described to modulate proliferation and commitment of NSCs. Histamine levels are increased in the brain parenchyma and at the cerebrospinal fluid (CSF) upon inflammation and brain injury, thus being able to modulate neurogenesis. Herein, we add new data showing that in vivo administration of histamine in the lateral ventricles has a potent proneurogenic effect, increasing the production of new neuroblasts in the SVZ that ultimately reach the olfactory bulb (OB). This report emphasizes the multidimensional effects of histamine in the modulation of NSCs dynamics and sheds light into the promising therapeutic role of histamine for brain regenerative medicine.

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Section: Introductionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis

et al. 2014

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“…Supporting our findings, in other systems histamine has been shown to also be required for cellular proliferation. For example, during neural stem cell proliferation, histamine is necessary to increase cellular differentiation (49). Histamine has also been shown to induce airway smooth muscle cell hyperplasia (46).…”

Section: Discussionmentioning

confidence: 99%

Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling

Graf

Meng

Hargrove

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Histidine is converted to histamine by histidine decarboxylase (HDC). We have shown that cholangiocytes 1) express HDC, 2) secrete histamine, and 3) proliferate after histamine treatment via ERK1/2 signaling. In bile duct-ligated (BDL) rodents, there is enhanced biliary hyperplasia, HDC expression, and histamine secretion. This studied aimed to demonstrate that knockdown of HDC inhibits biliary proliferation via downregulation of PKA/ERK1/2 signaling. HDC(-/-) mice and matching wild-type (WT) were subjected to sham or BDL. After 1 wk, serum, liver blocks, and cholangiocytes were collected. Immunohistochemistry was performed for 1) hematoxylin and eosin, 2) intrahepatic bile duct mass (IBDM) by cytokeratin-19, and 3) HDC biliary expression. We measured serum and cholangiocyte histamine levels by enzyme immunoassay. In total liver or cholangiocytes, we studied: 1) HDC and VEGF/HIF-1α expression and 2) PCNA and PKA/ERK1/2 protein expression. In vitro, cholangiocytes were stably transfected with shRNA-HDC plasmids (or control). After transfection we evaluated pPKA, pERK1/2, and cholangiocyte proliferation by immunoblots and MTT assay. In BDL HDC(-/-) mice, there was decreased IBDM, PCNA, VEGF, and HDC expression compared with BDL WT mice. Histamine levels were decreased in BDL HDC(-/-). BDL HDC(-/-) livers were void of necrosis and inflammation compared with BDL WT. PKA/ERK1/2 protein expression (increased in WT BDL) was lower in BDL HDC(-/-) cholangiocytes. In vitro, knockdown of HDC decreased proliferation and protein expression of PKA/ERK1/2 compared with control. In conclusion, loss of HDC decreases BDL-induced biliary mass and VEGF/HIF-1α expression via PKA/ERK1/2 signaling. Our data suggest that HDC is a key regulator of biliary proliferation.

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“…Cell proliferation is the first step in neurogenesis that is followed by cell differentiation (Rodriguez-Martinez et al, 2012). There is evidence that histamine induces cell proliferation via the stimulation of rospero1 and neurogenin 1.…”

Section: Histamine and Neurogenesismentioning

confidence: 99%

Neuronal histamine and cognitive symptoms in Alzheimer's disease

et al. 2016

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Histamine is required during neural stem cell proliferation to increase neuron differentiation

Cited by 37 publications

References 44 publications

New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis

New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis

Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling

Neuronal histamine and cognitive symptoms in Alzheimer's disease

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