Histamine Release from Isolated and Intact Mast Cells of Rats

Gb, West

doi:10.1159/000232822

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1982

1993

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Cited by 4 publications

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“…Much of this conclusion results from the finding that relatively large concen trations of dextran are required to release histamine from isolated cells. With con A, the reverse is true as this releaser is very active in vitro [7].…”

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confidence: 98%

Ethylenediamine Tetraacetic Acid and Histamine Release from Rat Mast Cells

West¹

1982

Int Arch Allergy Immunol

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The action of ethylenediamine tetraacetic acid (EDTA) on the release of histamine induced by clinical dextran, concanavalin A and compound 48/80 has been studied in rats after intraperitoneal and intrapedial injection as well as in tubes containing isolated peritoneal mast cells. Whereas large doses of EDTA were required for inhibiting histamine release in the whole animal, relatively much smaller concentrations were necessary when the inhibitor was injected locally into the paw or included in the incubation mixture with isolated cells. When dextran was used as the histamine releaser, EDTA was relatively much more effective an inhibitor in vitro than in vivo.

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confidence: 98%