Histamine Synthesis by White Cells during Storage of Platelet Concentrates

Muylle, L.; Beert, J. F.; Mertens, Gerhard; Bult, Hidde

doi:10.1046/j.1423-0410.1998.7430193.x

Cited by 8 publications

(5 citation statements)

References 19 publications

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“…We conclude that both donor and recipient factors are associated with incident ATRs. Furthermore, we conclude that storage‐related effects, such as proallergic mediators that accumulate during storage 22,23 or through interaction with plastic 24 do not appear to be as strongly associated with ATRs as donor and recipient factors. There are likely both donor and recipient attributes that are needed concurrently to elicit an ATR, and their relative contributions to an ATR developing may change with time and circumstances.…”

Section: Discussionmentioning

confidence: 81%

Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes

et al. 2011

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Section: Discussionmentioning

confidence: 81%

Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes

et al. 2011

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“…Subsequently, the buffycoats from three donors are washed in PAS, pooled and centrifuged before transferal to a storage bag. At storage the BCPC units have a leukocyte count, which may be too low to contribute with further histamine accumulation during storage [19]. The histamine concentration in APC units was within the range in plasma from normal donors.…”

Section: Discussionmentioning

confidence: 87%

Extracellular accumulation of bioactive substances during preparation and storage of various platelet concentrates

et al. 2001

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Background: Side effects of platelet transfusion may be associated with infusion of bioactive substances. We therefore studied extracellular accumulation of histamine, plasminogen activator inhibitor (PAI)-1, vascular endothelial growth factor (VEGF), and interleukin (IL)-6 during preparation and storage of various platelet concentrates. Methods: Twenty buffy-coat-derived platelet pools (BCPC) were prepared and stored in platelet additive solutions (PAS). Twelve apheresis platelet (APC) units were prepared using the COBE Spectra LRS, and 14 were prepared using the Fenwal Amicus Separator. After preparation half of the content was drawn from each APC unit. The normal ranges of the substances were determined in plasma from all donors, and the extracellular concentrations of the substances were determined in supernatants collected on days 0, 1, 3, 5, and 7 of storage from all platelet preparations. Results: The platelet counts were not significantly different in BCPC units and APC units. The BCPC units had a significantly higher white cell count than the APC units (P < 0.0001), but the count was significantly higher in the Amicus APC units than in the COBE APC units (P < 0.0001). The extracellular histamine concentration was significantly (P < 0.001) increased in BCPC units after preparation and without further increase during storage, while there was no accumulation of histamine in APC units. After preparation the PAI-1 concentration was significantly (P < 0.02) higher in BCPC units than in APC units, but during storage PAI-1 increased significantly (P < 0.05) more in APC units than in BCPC units. Similarly, VEGF concentration was significantly (P < 0.05) higher in BCPC units than in APC units after preparation. During storage, however, VEGF increased more in BCPC units compared with COBE Spectra APC units (P < 0.05), but compared with Amicus Separator APC units only for the first 3 days of storage. At days 5 and 7 of storage the VEGF concentration was significantly higher in the Amicus APC units than in the COBE APC units (P < 0.05). IL-6 was not detectable in any of the concentrates after preparation or during storage. Conclusion: Platelet concentrates prepared by the apheresis method may contain less white cell derived bioactive substances than platelet concentrates prepared by the buffy-coat method. However, a substantial storage time dependent platelet derived bioactive substance accumulation takes place in all platelet concentrates tested, presumably due to platelet disintegration. Am. J. Hematol. 67:157-162, 2001.

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“…Histamine is present in blood components. Levels of histamine in blood components depend on the number of WBCs and duration of storage; however, leukoreduction markedly reduces plasma concentrations in blood components 82‐86 . The lack of an effect of leukoreduction on incidence rates of ATRs argues against a role for passive transfer of histamine as a cause of ATRs.…”

Section: Relationship Of Specific Mediators and Predispositions To Atrsmentioning

confidence: 99%

Scratching the surface of allergic transfusion reactions

et al. 2012

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Allergic transfusion reactions (ATRs) are a spectrum of hypersensitivity reactions that are the most common adverse reaction to platelets and plasma, occurring in up to 2% of transfusions. Despite the ubiquity of these reactions, little is known about their mechanism. In a small subset of severe reactions, specific antibody has been implicated as causal, although this mechanism does not explain all ATRs. Evidence suggests that donor, product, and recipient factors are involved, and it is possible that many ATRs are multi-factorial. Further understanding of the mechanisms of ATRs is necessary so that rationally designed and cost-effective prevention measures can be developed.

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Histamine Synthesis by White Cells during Storage of Platelet Concentrates

Abstract: Histamine is not synthesized during storage of platelets, whereas IL-6 is. The addition of disodium cromoglycate, a substance that inhibits granulocyte activation, had no effect on the release of histamine or on the total histamine content at various storage times.

Cited by 8 publications

References 19 publications

Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes

Allergic transfusion reactions to platelets are associated more with recipient and donor factors than with product attributes

Extracellular accumulation of bioactive substances during preparation and storage of various platelet concentrates

Scratching the surface of allergic transfusion reactions

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