Histidine polypeptide-hybridized nanoscale metal–organic framework to sense drug loading/release

Xu, Yanan; Li, Zhenhua; Xiu, Dan; Sun, Guotao; Snow, Christopher D.; Wang, Yao; Belfiore, Laurence A.; Tang, Jianguo

doi:10.1016/j.matdes.2021.109741

Cited by 17 publications

(7 citation statements)

References 43 publications

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“…If embraced and honed, protein crystals would represent a new class of functional materials, with applications in sorting and storage, but with highly customizable inner surfaces. The highly ordered crystal framework has been recognized as a functional assembly joining the ranks of other well established porous materials like zeolites or metal‐organic frameworks (MOFs; Safaei et al, 2019; Xu et al, 2021; Yuan et al, 2018) or the recently described protein‐metal‐organic frameworks (POFs) that use metal–protein complexes in place of metal nodes (Bailey et al, 2017; Sontz et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Diverse crystalline protein scaffolds through metal‐dependent polymorphism

Liutkus,

Sasselli,

Rojas

et al. 2024

Protein Science

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As protein crystals are increasingly finding diverse applications as scaffolds, controlled crystal polymorphism presents a facile strategy to form crystalline assemblies with controllable porosity with minimal to no protein engineering. Polymorphs of consensus tetratricopeptide repeat proteins with varying porosity were obtained through co‐crystallization with metal salts, exploiting the innate metal ion geometric requirements. A single structurally exposed negative amino acid cluster was responsible for metal coordination, despite the abundance of negatively charged residues. Density functional theory calculations showed that while most of the crystals were the most thermodynamically stable assemblies, some were kinetically trapped states. Thus, crystalline porosity diversity is achieved and controlled with metal coordination, opening a new scope in the application of proteins as biocompatible protein‐metal‐organic frameworks (POFs). In addition, metal‐dependent polymorphic crystals allow direct comparison of metal coordination preferences.

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Section: Introductionmentioning

confidence: 99%

Diverse crystalline protein scaffolds through metal‐dependent polymorphism

Liutkus,

Sasselli,

Rojas

et al. 2024

Protein Science

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“…Zeolitic imidazolate framework-8 (ZIF-8), a zinc-based MOF, possesses a large specific surface area, high drug-loading capacity and porosity, excellent mechanical stability, and tunable surface characteristics. , ZIF-8 remains structurally stable under normal physiological conditions. However, in the mildly acidic environment of tumor tissue, the protonation of organic ligands in the framework of ZIF-8 will accelerate its degradation, , which possesses tremendous potential in the field of drug delivery. To endow MIPs with a higher drug loading capacity, better biocompatibility, and controlled drug release, this research innovatively proposed using hydrophilic material hyaluronic acid (HA)-modified ZIF-8 loaded with anticancer drug doxorubicin (DOX) (ZIF-8/DOX-HA) as a substrate to prepare the molecularly imprinted film on its surface to improve the drug loading performance, which further protect the stable encapsulation of the drug in ZIF-8 and reduce toxic and side effects in normal tissues.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Imprinted Polymer Based on ZIF-8/DOX-HA for Synergistically Targeting Prostate Cancer Cells and Controlled Drug Release with Multiple Responses

Song

Shuang

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Improving the drug loading and delivery efficiency of biodegradable nanomaterials used for targeting prostate cancer (PCa) remains a challenging task. To accomplish this task, herein, a new surface molecularly imprinted polymer (ZIF-8/DOX-HA@MIP) was designed and constructed with a hyaluronic acid (HA)-modified zeolitic imidazolate framework-8 (ZIF-8) metal–organic framework loaded with doxorubicin (DOX) as a substrate and a responsive molecularly imprinted polymer film as a shell. Owing to the large surface area of ZIF-8, DOX was successfully loaded into the ZIF-8/DOX-HA@MIP with a high drug loading efficiency (more than 88%). In vitro cell experiments have shown that the strengthened targeting ability of ZIF-8/DOX-HA@MIP to PCa cells was realized through the synergistic effect of HA and the molecularly imprinted membrane. Under the condition of simulated tumor microenvironment solution, Zn species were released and the particle size of ZIF-8/DOX-HA@MIP decreased gradually by the synergistic effect of hyaluronidase, pH, and glutathione, showing excellent biodegradability. In vivo antitumor research indicated the excellent antitumor activity and biocompatibility of ZIF-8/DOX-HA@MIP. The multifunctional ZIF-8/DOX-HA@MIP constructed herein provides a novel impetus for the development of targeted drug delivery in PCa treatment and a new strategy for treating other tumors.

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“…Nowadays, the application of MOFs in biomedicine is mature. The formation of stable host-guest structures with MOFs enables the immobilization of biomacromolecules, such as proteins (enzymes, [14][15][16][17][18][19][20] antigens and antibodies, [21][22][23][24] and protein drugs [25][26][27][28][29][30][31] ), nucleic acids (DNA [32][33][34][35][36][37] and RNA [38][39][40][41][42] ), and other biomacromolecular drugs, [43][44][45][46][47][48][49] for immunotherapy, starvation therapy, oxidation therapy, gene therapy, and other different therapeutic approaches. [50] However, in 2005, Prof. Yaghi's group had proposed another innovative structure-covalent organic frameworks (COFs).…”

Section: Introductionmentioning

confidence: 99%

Covalent Organic Frameworks as a Biomacromolecule Immobilization Platform for Biomedical and Related Applications

Wang

Lewis

Wang

et al. 2022

Advanced Therapeutics

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With the development of biotherapeutic field, biomacromolecules with definite curative and small side effects have gradually become a hot spot in the research and development of new drugs. However, the use of biomacromolecules as drug candidates pose some technical difficulties related to their medicinal properties, mainly drug stability and in vivo transport and delivery. Currently, diverse nanodrug delivery systems have been used to deliver biomacromolecules because they can maintain stability, significantly increase bioavailability, and improve targeted distribution of biomacromolecules, thereby improving efficacy and reducing toxicity. In recent years, covalent organic frameworks (COFs) have attracted increasing interest as stable, efficient, and reusable biomacromolecule immobilization carriers. COFs exhibit good stability and biocompatibility with no biological toxicity, making them outstanding host materials for immobilizing biomacromolecules. However, the synthesis of COFs requires severe experimental conditions; the commonly used strategies for immobilizing biomacromolecules in metal-organic frameworks (MOFs), such as biomimetic mineralization, one-pot synthesis, and coprecipitation, are likely not applicable to COFs. Herein, three strategies for immobilizing biomacromolecules in COFs and the multifunctional biomedical applications of the biomacromolecule@COF composite systems are reviewed. Next, the superior properties and cutting-edge applications of MOFs are mentioned and then the advantages of COF-MOF hybrid materials are highlighted.

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Histidine polypeptide-hybridized nanoscale metal–organic framework to sense drug loading/release

Cited by 17 publications

References 43 publications

Diverse crystalline protein scaffolds through metal‐dependent polymorphism

Diverse crystalline protein scaffolds through metal‐dependent polymorphism

Biodegradable Imprinted Polymer Based on ZIF-8/DOX-HA for Synergistically Targeting Prostate Cancer Cells and Controlled Drug Release with Multiple Responses

Covalent Organic Frameworks as a Biomacromolecule Immobilization Platform for Biomedical and Related Applications

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