2023
DOI: 10.48057/hematologa.v26i3.475
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Histiocitosis de células de Langerhans en adultos. Reporte de 2 casos

Abstract: La histiocitosis de células de Langerhans (HCL) es una neoplasia mieloide de células dendríticas (CD) caracterizada por la expansión clonal de precursores mieloides que expresan los antígenos de superficie CD1a+ y CD207+ (langerina). La HCL es una enfermedad rara e infrecuente, de aparición predominantemente pediátrica con una incidencia anual que oscila entre 2 y 9 casos por millón, siendo aun más rara en adultos, con una incidencia anual estimada de aproximadamente 1 caso por millón, aunque probablemente est… Show more

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Cited by 1 publication
(2 citation statements)
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“…In contrast to usual skin cells, pathological Langerhans cells appear round, functionally and immunologically immature, surrounded by eosinophiles, macrophages, lymphocytes, and sometimes giant multinucleate cells 5 . Diagnosis is performed by biopsy of the lesion to ascertain presence of Birbeck granules, and immunohistochemical confirmation by the markers CD1a, S100 or CD207.…”
Section: Introductionmentioning
confidence: 90%
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“…In contrast to usual skin cells, pathological Langerhans cells appear round, functionally and immunologically immature, surrounded by eosinophiles, macrophages, lymphocytes, and sometimes giant multinucleate cells 5 . Diagnosis is performed by biopsy of the lesion to ascertain presence of Birbeck granules, and immunohistochemical confirmation by the markers CD1a, S100 or CD207.…”
Section: Introductionmentioning
confidence: 90%
“…It has been associated to a mutation of the gene BRAF 600 E and activation of ERK 1-3 . In 50 % to 90 % of the cases diagnosed, patients are between less than one year old to 15 years old 4 , with an estimated annual incidence of 2 to 10 cases per million children 5 .…”
Section: Introductionmentioning
confidence: 99%