Histochemical alterations in rabbit testis produced by manganese chloride

Imam, Zaka; Chandra, Satya V.

doi:10.1016/0041-008x(75)90118-0

Cited by 33 publications

(2 citation statements)

References 9 publications

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“…Increase in the activity of testicular G6PDH associated with the damage to seminiferous tubules has been reported in manganese-and styrene-treated animals (Imam and Chandra 1975;Srivastava et al 1989). The increase in the activity of G6PDH observed in the DBP-treated animals is probably due to the damage and shrinkage of the tubular component of the testis.…”

Section: Discussionmentioning

confidence: 87%

Testicular effects of di-n-butyl phthalate (DBP): Biochemical and histopathological alterations

et al. 1990

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Di-n-butyl phthalate (DBP) was administered to young male rats by gavage at the doses of 250, 500 and 1,000 mg/kg body weight/day for 15 days. A significant decrease in testes weight was observed at 500 and 1,000 mg/kg doses of DBP. Histopathological examination revealed marked degeneration of seminiferous tubules. The activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as sorbitol dehydrogenase and acid phosphatase, were decreased significantly, while that of lactate dehydrogenase was significantly increased, coincident with degeneration of spermatogenic cells. The activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells, beta-glucuronidase, gamma-glutamyl transpeptidase and glucose-6-phosphate dehydrogenase were significantly increased. Thus the alterations in activity of these testicular cell specific enzymes suggest that DBP exposure during early life could affect the testicular functions.

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Section: Discussionmentioning

confidence: 87%

Testicular effects of di-n-butyl phthalate (DBP): Biochemical and histopathological alterations

et al. 1990

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“…Damage to peripheral glands such as testis or adrenals can also upset the normal hypothalamohyphophyseal feedback mechanisms by which their secretion is regulated. For example, while manganese is generally thought to directly damage certain nerve pathways, it also has a damaging effect on the testis (Imam and Chandra, 1975 Hong et al, 1984) may also modify an animal's behavioral characteristics. Altered production of trophic hormones can then cause a variety of behavioral changes.…”

Section: Goals Of Neurotoxic Studymentioning

confidence: 99%

The biochemical evaluation of neurotoxic damage

Bondy

1986

Fundamental and Applied Toxicology

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The specific problems related to the study of chemicals that damage the nervous system are discussed. Such damage may be direct or may occur by a series of sequential events. Such a series of events may involve other organs and biochemical targets not confined to nerve tissue. The complexity of investigation of the mode of action of rather nonspecific toxic agents requires that a circumscribed objective be defined and examples of such goals are given. One of these is to attempt to determine which neuronal circuits are damaged by a given toxic agent and how this might cause alterations of behavior. Acrylamide and triethyl lead are used to exemplify the application of neurotransmitter receptor analysis to correlation of deranged nerve activity patterns with modulation of behavior. Such evaluation can set the stage for more detailed biochemical studies of neurotoxic mechanisms.

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