Histocompatibility antigens controlled by the I region of the murine H-2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity.

Klein, Jan; Chiang, Chinlee; Hauptfeld,

doi:10.1084/jem.145.2.450

Cited by 62 publications

(7 citation statements)

References 14 publications

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“…Not suprisingly, anti-H-2 antisera (in this case, anti-H2'') also inhibited the CTL-target cell interaction. Although I region specific CTL have been described (Billings et al 1978, Klein et al 1977, we know of no evidence to suggest that the I region plays a role at the effector cell level in the CTL-target cell interaction in viral systems.…”

Section: Mhc Restriction Oe Effector-target Cell Interactionsmentioning

confidence: 99%

Induction, Control and Consequences of Virus Specific Cytotoxic T Cells

Finberg

Benacerraf

1981

Immunological Reviews

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Section: Mhc Restriction Oe Effector-target Cell Interactionsmentioning

confidence: 99%

Induction, Control and Consequences of Virus Specific Cytotoxic T Cells

Finberg

Benacerraf

1981

Immunological Reviews

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“…It would seem, therefore, that with respect to Tc cell recognition D' is in a category similar to I region-coded antigens. Such antigens can be recognized by some clones in allogeneic Tc cell populations, (30)(31)(32), albeit at a lower frequency that H-2K or H-2D antigens, but they are not directly involved in the recognition by Tc cells of virus-infected self cells, or H-2 compatible cells bearing non-self minor H antigens (3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic T-cell responses show more restricted specificity for self than for non-self H-2D-coded antigens

Blanden¹,

Kees²

1978

The Journal of Experimental Medicine

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The specificity of recognition of H-2 antigens by various subsets of Tc cells was investigated with respect to the two separate molecules known to be coded in the H-2D(d) region (a) D which carries the private specificity H-2.4 and (b) D' which carries the public specificity H-2.28. BALB/c.H-2(db) mutant mice express D but not D' on their cell surfaces, whereas wild-type BALB/c mice express both D and D'. H-2 restricted Tc cells specific for viral-plus- H-2D(d)-coded antigens on infected self cells, or minor H-plus-H-2D(d)-coded antigens on H-2-compatible cells apparently recognize D, but do not detectably recognize D. In contrast, BALB/c-H-2(db) anti-BALB/c Tc cell responses do recognize D' (the only known antigen which is not shared by mutant and wild-type); furthermore, D' is also detectably recognized by a significant proportion of the Tc cells that respond in MLR to H-2D(d)-coded antigens. In these latter responses, D' was recognized separately from D, i.e., the response was not "H-2 restricted". These results indicate that H-2 restricted Tc cell responses to modified-self cells are more specific for self H-2D(d)-coded antigens then are allogeneic Tc cell responses directed at the same antigens, in that haplotype-unique (private) specificity recognition (of the D molecule) exclusively occurs only in the former, not the latter case. The implications of this specificity of H-2 restricted responses for possible processes of somatic selection of anti-self recognition structures on progenitor Tc cells are briefly discussed.

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“…But, as Table 1 shows (see also Ref. 16), class I identity between stimulator and target is not required for class I1 CML to occur. In this experiment, we generated effector cells against Ik (class 11) antigens in the context of H-2KaH-2Dd class I antigens and tested the effectors against targets carrying Ik antigens in the context of H-2KkH-2Dk antigens.…”

Section: K-ization Of the I Regionmentioning

confidence: 92%

The unity of genes in the Major histocompatibility complex

Klein

1978

Arthritis & Rheumatism

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The major histocompatibility complex (MHC) of the mouse can be genetically divided into several regions specialized to performing specific functions. Thus the class I regions (K and D ) code for antigens that activate effector (killer) T cells, class I1 region (I) for antigens causing T-cell proliferation, and class I11 regions ( 8 ) for complement components. A strong case is made for the theory that the division of labor within the MHC is not absolute. Evidence is presented that class I antigens can sometimes cause as strong T-cell proliferation as class I1 antigens; that class I1 antigens can generate effector T cells; and that class I antigens may be involved in the immune response to some antigens. The fact that different regions can perform similar functions argues for the unity of the MHC genes.

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Histocompatibility antigens controlled by the I region of the murine H-2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity.

Cited by 62 publications

References 14 publications

Induction, Control and Consequences of Virus Specific Cytotoxic T Cells

Induction, Control and Consequences of Virus Specific Cytotoxic T Cells

Cytotoxic T-cell responses show more restricted specificity for self than for non-self H-2D-coded antigens

The unity of genes in the Major histocompatibility complex

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