Histocompatibility (HL-A) Antigens Associated with Psoriasis

Russell, Thomas J.; Schultes, Lorain M.; Kuban, Donald J.

doi:10.1056/nejm197210122871503

Cited by 336 publications

(141 citation statements)

References 10 publications

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“…The restults stupport observations previouisly reported on HLA-A1 and B17 in this disease (11)(12)(13)(14)(15)(16)(17)(18)(19). HLA-A1 wats fouind to be parit of the "psoriasis halplotvpe" in famiiily sttudies (25,26).…”

Section: Discussionsupporting

confidence: 57%

See 1 more Smart Citation

Histocompatibility alloantigens in psoriasis and psoriatic arthritis. Evidence for the influence of multiple genes in the major histocompatibility complex.

Murray¹,

Mann²,

Gerber³

et al. 1980

J. Clin. Invest.

106

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A B S T R A C T The frequency of HLA-A, B, and Cw antigens as well as the antigens expressed preferentially on B cells and monocytes (DRw and Il-like) was examinied in a normal popuilation alnd two related disease populations, psoriasis and psoriatic arthritis. HLA antigens distinguishing the two disease populations were fouind. Psoriatic patients demonstrated an increase in frequency of HLA-A1, B17, and B13. Patients with psoriatic arthritis demonstrated an increased frequency of HLA-A26, B38, and DRw4. Antigens showing a common increase in frequiency in the two disease populations were HLA-Cw6, DRw7, and la744. These results demonstrate genetic differences as well as similarities in the two populations of patients with the common clinical feature of psoriasis. In addition to the above analysis, we examiined the association of individual alloantigens elevated in frequency in the diseased population. These same alloantigens were examined for association in the normal population. This analysis revealed HLA antigen associations in the two disease groups that differed from the association of several antigens in the normal population.The results suggest that at least two genetic factors, one mapping in the HLA-A, C-B region and one mapping in the HLA-B-DRw region are associated with the disease states. Thus, multiple factors controlled by genes Dr. C. Murray is a Research

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Section: Discussionsupporting

confidence: 57%

“…Antigenis controlled by HLA-A, B, and C loci are serologically defined in cytotoxicity assays, and the D locus is detected bv a mnixed lymnphocyte reaction. It has been reported that the HLA-B13, B17, B37, Bw16, Cw3, and Cw6 halve inereased frequiencies in psoriasis (10)(11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Histocompatibility alloantigens in psoriasis and psoriatic arthritis. Evidence for the influence of multiple genes in the major histocompatibility complex.

Murray¹,

Mann²,

Gerber³

et al. 1980

J. Clin. Invest.

106

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show abstract

“…A potential psoriasis locus in the MHC had been long suspected, based on serologic typing identifying an association between psoriasis and the HLA-Cw Ã 060 allele of the MHC class I molecule HLA-C (Russell et al 1972;Tiilikainen et al 1980). However, the identification of the actual causative PSORS1 gene has proven to be challenging because of the extensive linkage disequilibrium (LD)-the tendency for particular alleles at two or more loci to be inherited together more often than would be predicted by chance-present within the MHC.…”

Section: Psors1mentioning

confidence: 99%

Psoriasis

Meglio

Villanova

Nestle

2014

Cold Spring Harbor Perspectives in Medicine

267

202

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Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.This skin is me, I can't get out.

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“…As with most autoimmune diseases, there is a strong contribution of HLA alleles, particularly Cw6 and B57 (7)(8)(9)(10)(11)(12). PS can also be independent of HLA, and genetic linkage studies of multiply affected families have mapped susceptibility loci to chromosomes 1q21, 3q21, 4q, 14q31, 17q24-q25 and 19p13 (1,(13)(14)(15)(16)(17) (unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies

Bowcock

Shannon

et al. 2001

Human Molecular Genetics

241

199

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Approximately 2% of the Caucasian population is affected by psoriasis (PS); a chronic inflammatory skin disease triggered by both genetic and environmental risk factors. In addition to a major contribution from the HLA class I region, PS susceptibility loci have been mapped to a number of regions including 1q21, 3q21, 4qter, 14q31-q32, 17q24-q25, 19p13.3 and 20p. Some of these overlap with loci implicated in other autoimmune/inflammatory diseases. Global gene expression studies are beginning to provide insights into the etiology of these and other complex diseases. We used Affymetrix oligonucleotide arrays comprising approximately 12 000 known genes to initiate a more comprehensive analysis of the transcriptional changes that occur in involved and uninvolved skin of 15 psoriatic patients versus six normal controls. Expression levels of the transcripts detected on the arrays were first used to determine the relationship of samples to each other using hierarchical clustering. This analysis clearly differentiated involved psoriatic skin from uninvolved and normal skin. Clusters of differentially expressed genes with similar expression patterns in the same samples were then identified. Six out of 32 clusters contained a total of 177 transcripts that were differentially expressed in involved psoriatic skin versus normal skin. These differences were independent of the gender, age, skin site and HLA class I status of the patient. Ten of the 177 genes were also differentially expressed in uninvolved skin, and several mapped to regions previously shown to harbor psoriasis susceptibility loci.

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Histocompatibility (HL-A) Antigens Associated with Psoriasis

Cited by 336 publications

References 10 publications

Histocompatibility alloantigens in psoriasis and psoriatic arthritis. Evidence for the influence of multiple genes in the major histocompatibility complex.

Histocompatibility alloantigens in psoriasis and psoriatic arthritis. Evidence for the influence of multiple genes in the major histocompatibility complex.

Psoriasis

Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies

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