Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy

Kimura, Wataru; Morikane, Keita; Esaki, Yukiyoshi; Chan, Wing C.; Pour, Parviz M.

doi:10.1002/(sici)1097-0142(19980515)82:10<1839::aid-cncr5>3.0.co;2-i

Cited by 55 publications

(26 citation statements)

References 21 publications

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“…Nonsurgical treatments offer little, if any, survival advantage. As a result, mortality almost parallels its incidence, with a 5-year survival rate of less than 10% (Kimura et al, 1998). There are only few substantial data reporting clinical significant prognostic markers for pancreatic cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

et al. 2005

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Pancreatic cancer is one of the most aggressive gastrointestinal cancer with less than 10% long-term survivors. The apoptotic pathway deregulation is a postulated mechanism of carcinogenesis of this tumour. The present study investigated the prognostic role of apoptosis and apoptosis-involved proteins in a series of surgically resected pancreatic cancer patients. All patients affected by pancreatic adenocarcinoma and treated with surgical resection from 1988 to 2003 were considered for the study. Patients' clinical data and pathological tumour features were recorded. Survivin and Cox-2 expression were evaluated by immunohistochemical staining. Apoptotic cells were identified using the TUNEL method. Tumour specimen of 67 resected patients was included in the study. By univariate analysis, survival was influenced by Survivin overexpression. The nuclear Survivin overexpression was associated with better prognosis (P ¼ 0.0009), while its cytoplasmic overexpression resulted a negative prognostic factor (P ¼ 0.0127). Also, the apoptotic index was a statistically significant prognostic factor in a univariate model (P ¼ 0.0142). By a multivariate Cox regression analysis, both the nuclear (P ¼ 0.002) and cytoplasmic (P ¼ 0.040) Survivin overexpression maintained the prognostic statistical value. This is the first study reporting a statistical significant prognostic relevance of nuclear and cytoplasmic Survivin overexpression in pancreatic cancer. In particular, patients with high nuclear Survivin staining showed a longer survival, whereas patients with high cytoplasmic Survivin staining had a shorter overall survival.

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Section: Discussionmentioning

confidence: 99%

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

et al. 2005

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“…2 The highest incidence of K-ras mutation has been found in ductal adenocarcinoma of the pancreas, in which it ranges from 70-100%. [3][4][5] Because K-ras mutations have been found in very small incidental carcinomas, which were diagnosed only at autopsy, 6 as well as in intraductal portions of ductal carcinomas, it is considered an initial event in carcinoma development. This may make it a good tool for detecting pancreatic carcinomas at an early stage.…”

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confidence: 99%

The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium

Lüttges¹,

Schlehe²,

Menke³

et al. 1999

Cancer

130

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“…For these reasons, estimation of the exact duration needed to conclude that the diabetes occurred before or after the development of PC is difficult. The incidental pancreatic cancer detection indicates that this cancer can remain silent for a considerable time or grow very slowly 17 . Nevertheless, the notion that diabetes is a predisposing factor for PC remains questionable.…”

Section: Introductionmentioning

confidence: 99%

Type 2 Diabetes and Pancreatic Cancer – A Possible Reason

Pour¹

2011

Medical Complications of Type 2 Diabetes

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Histologic and biologic patterns of microscopic pancreatic ductal adenocarcinomas detected incidentally at autopsy

Cited by 55 publications

References 21 publications

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients

The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium

Type 2 Diabetes and Pancreatic Cancer – A Possible Reason

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