Histologic evolution of recurrent basal cell carcinoma and treatment implications

Lang, P.G.; Maize, John C.

doi:10.1016/s0190-9622(86)70020-0

Cited by 172 publications

(101 citation statements)

References 34 publications

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“…58 For the studies of treatments of BCC, the heterogeneity is large. From the literature, it is known that the risk for the recurrence of a treated BCC depends not only on the treatment modality but also on the location 59,60 ; on the size and histologic subtype of the tumor 61,62 ; and to a lesser degree, on patient-specific aspects such as age, immune status, and sex. 63 Especially with the micronodular, adenoid, and morphea subtypes of BCC and tumors localized in the H figure (danger zone) of the face, those larger than 2 cm are associated with a higher risk for recurrence.…”

Section: Effectiveness or Recurrence Ratesmentioning

confidence: 99%

A Systematic Review of Treatment Modalities for Primary Basal Cell Carcinomas

Thissen¹,

Neumann²,

Schouten³

1999

Arch Dermatol

346

257

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Section: Effectiveness or Recurrence Ratesmentioning

confidence: 99%

A Systematic Review of Treatment Modalities for Primary Basal Cell Carcinomas

Thissen¹,

Neumann²,

Schouten³

1999

Arch Dermatol

346

257

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“…Esto es más llamativo en el libro editado por Maize (l2), uno de los autores pioneros que llamó la atención sobre la capacidad agresiva y recidivante del carcinoma basocelular con patrón micronodular (7). El capítulo sobre Tumores malignos de la epidermis es prácticamente el mismo en los libros de Maize (12) y de Farmer y Hood (1 l), con pequeñas adiciones y actualizaciones en este último.…”

Section: Criterios De Clasificaciónunclassified

El informe histológico del carcinoma basocelular

Rodríguez

Hart

2001

biomedica

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o iin Dcrnialu.og a In-iii~iu luac una. rln C a n~e r o ugia I.n duu ae Derniaiu oga Fac~itao O P Mea cioa Jniveiso30 hac!uila nn Coonloia Bugola D C . CCIUIIIU~ En Colombia, ha sido costumbre hacer el informe microscópico del carcinoma basocelular sin referencia a sus patrones histológicos; es común que sólo diga 'carcinoma basocelular', sin descripción de las características microscópicas. El objetivo de este trabajo es hacer recomendaciones sobre la manera de realizar el informe histológico de este tumor, refiriéndose a sus patrones microscópicos más importantes y a otras características como su dispersión y la invasión perinerural porque tienen importancia en el pronóstico y tratamiento del paciente. Entre los múltiples patrones histológicos que adopta el carcinoma basocelular, los más comunes y de importancia pronóstica son: nodular, superficial, micronodular, trabecular, morfeiforme y fibroepitelial. El carcinoma basocelular micronodular, el trabecular y el morfeiforme son los que más extensión subclínica presentan, los más infiltrantes en profundidad, capaces de dar invasión perineural y de ser los que con mayor frecuencia recidivan, si no se resecan con márgenes suficientes o con cirugía micrográfica de Mohs. Tienen un patrón de crecimiento difuso. El carcinoma basoescamoso es ocasional y tiene capacidad de dar metástasis. El informe histológico del carcinoma basocelular debe incluir una descripción que precise el patrón histológico, el crecimiento disperso o circunscrito y la presencia o ausencia de invasión perineural; debe informar su extensión y localización: si está unido al epitelio, a qué nivel de la dermis penetra y si alcanza la grasa subcutánea o el tejido muscular. El conocimiento de estos datos permite al dermatólogo establecer el pronóstico y hacer el tratamiento más adecuado en cada caso.Palabras clave: carcinoma basocelular, patrones histológicos, informe histopatológico. Histological repon of basal cell carcinomaIn Colombia, the histopathological studies of the basal cell carcinoma are reported without reference to its microscopic characteristics. Herein, recommendations are presented for a more effective histophatological report of this tumor. Reference must be made to the important microscopic patterns as well as to features of dispersion, dissemination and perineural invasion -al1 important forthe prognosis and management of the patient. For prognosis, the most important histological patterns are nodular, superficial, micronodular, trabecular, morpheaform and fibroepithelial. Micronodular, trabecular and morpheaform basal cell carcinomas are those with the highest subclinical extension and are the most deeply infiltrating tumors, able to present perineural invasion and recurrence. They have a diffuse pattern of growth. Basosquamous cell carcinoma is rare and has the potential to metastasize. The histopathological report of basal cell carcinoma should include the description of its histological patterns, its growth type, if it is difíuse or circunscript, and the presence of perineural i...

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“…3,32,33 If the pattern could not be assessed because the biopsy specimen was too superficial, and the excisional specimen did not reveal residual tumor, the lesion was classified as "not otherwise specified." If a mixed subtype (such as superficial-nodular) was reported, or if a previous biopsy of the same lesion revealed a different subtype, the lesion was classified according to the most invasive subtype.…”

Section: Lesion Subtypementioning

confidence: 99%

“…If a mixed subtype (such as superficial-nodular) was reported, or if a previous biopsy of the same lesion revealed a different subtype, the lesion was classified according to the most invasive subtype. For statistical purposes, and based on their biological behavior, 3,32,33 a subgroup of noninvasive BCC was compiled by including all superficial and nodular BCCs. Conversely, the invasive BCC subgroup included micronodular, infiltrative, and morpheaform BCCs.…”

Section: Lesion Subtypementioning

confidence: 99%