Histologic Factors Associated With Need for Surgery in Patients With Pedunculated T1 Colorectal Carcinomas

Backes, Yara; Elias, Sjoerd G.; Groen, John N.; Schwartz, Matthijs P.; Wolfhagen, Frank H.J.; Geesing, Joost M J; Borg, Frank ter; Bergeijk, J. van; Spanier, B.W.M.; Cappel, Wouter H. de Vos tot Nederveen; Kessels, Koen; Seldenrijk, Cornelis A.; Raicu, Mihaela G.; Drillenburg, Paul; Milne, Anya N.; Kerkhof, Marjon; Seerden, Tom; Siersema, Peter D.; Vleggaar, Frank P.; Offerhaus, G. Johan A.; Laclé, Miangela M.; Moons, Leon M.G.

doi:10.1053/j.gastro.2018.01.023

Cited by 70 publications

(61 citation statements)

References 44 publications

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“…Lastly, Backes et al assessed the utility of incorporating PDC into a model aimed at assessing the need for surgical resection in pedunculated pT1 cancers. 27 They matched 37 cases with local recurrence, distant metastases and/or lymph node metastases, with 111 cases without, and compared rates of various histological parameters within the two groups. They found a significantly higher rate of high-grade PDC (defined as G2/G3 PDC ) in cases (62%) compared with controls (24%).…”

Section: Pdc In Metastatic Diseasementioning

confidence: 99%

“…5 Another study incorporated the presence of either Bd2/3 or G2/3 PDC as a single risk factor into a predictive model to determine the risk of lymph node metastasis in pedunculated pT1 cancers. 27 A handful of studies have compared protein expression and molecular profiles in PDC and TB, with most finding significant overlap between these two features. Hong et al evaluated the expression of beta-catenin, Ki-67, E-cadherin, mucin 1 (MUC1) and epithelial membrane antigen (EMA) in PDC, TB and background tumour.…”

Section: Pdc In Relation To Other Invasive Front Prognostic Markersmentioning

confidence: 99%

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Poorly differentiated clusters in colorectal cancer: a current review and implications for future practice

et al. 2020

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Summary Poorly differentiated clusters (PDC), defined as small groups of ≥5 tumour cells without glandular differentiation, have gained recent attention as a promising prognostic factor in colorectal cancer (CRC). Numerous studies have shown PDC to be significantly associated with other adverse histopathological features and worse clinical outcomes. PDC may hold particular promise in stage II colon cancer, where risk stratification plays a critical role in patient selection for adjuvant chemotherapy. In addition, emerging evidence suggests that PDC can predict lymph node metastasis in endoscopically resected pT1 CRC, potentially helping the selection of patients for oncological resection. In ‘head‐to‐head’ comparisons, PDC grade has consistently outperformed conventional histological grading systems both in terms of risk stratification and reproducibility. With a number of large‐scale studies now available, this review evaluates the evidence regarding the prognostic significance of PDC, considers its relationship with other emerging invasive front prognostic markers (such as tumour budding and stroma type), assesses its ‘practice readiness’, addressing issues such as interobserver reproducibility, scoring methodologies and special histological subtypes (e.g. micropapillary and mucinous carcinoma), and draws attention to ongoing challenges and areas in need of further study. Finally, emerging data on the role of PDC in non‐colorectal cancers are briefly considered.

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Section: Pdc In Metastatic Diseasementioning

confidence: 99%

Section: Pdc In Relation To Other Invasive Front Prognostic Markersmentioning

confidence: 99%

Poorly differentiated clusters in colorectal cancer: a current review and implications for future practice

et al. 2020

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“…13,34,35 On the other hand, the number as well as characteristics of pathological risk factors may be associated with regional lymph node metastasis risk. Backes et al 36 developed the LASSO (Least Absolute Shrinkage and Selection Operator) model to calculate the probability of pedunculated T1 cancer metastasis by inputting the presence or absence of various pathologic risk factors. Our study also con- Values are presented as number (%).…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery

et al. 2020

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cancer by routine screening tests and to then treat them to block further development into advanced colorectal cancer. Thus, clinical practice guidelines suggest various screening tests including colonoscopy. 3-5 Colonoscopy is especially useful due to its ability to detect and treat precancerous polyp and early colorectal cancer. 6 Of early colorectal cancers, superficial submucosal colorectal cancer (SSMC) defined by the depth of invasion from muscularis mucosa as less than 1,000 μm, can be completely cured by endoscopic resection if it does not have any adverse pathologic findings including poorly differentiated adenocar

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“…The least absolute shrinkage and selection operator (LASSO) method was originally designed for regression analysis [19]. Lately, it has been applied to many fields, including the construction of prognostic models for various cancers [20,21,22,23].…”

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confidence: 99%

Prognostic value of a metastasis-related gene signature in hepatocellular carcinoma

Zhou¹,

Jiang²

2020

Preprint

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Background: Surgery is a potential curative treatment for hepatocellular carcinoma (HCC), but postoperative recurrence occurs in majority of patients. Currently, there are no robust biomarkers to predict the disease progression or recurrence. Methods: Weighted gene correlation network analysis (WGCNA) was used to construct co-expression network. The least absolute shrinkage and selection operator (LASSO) method was applied to develop prognostic model. Survival analysis, gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) were performed to assess the performance. Results: By using GSE14520 dataset, 16 hub genes associated with HCC metastasis were screened. A signature of 5 metastasis-related genes was subsequently constructed by incorporating TCGA LIHC dataset. HCC patients with high risk score have low survival rate, low disease free survival rate and high recurrence rate. The prognostic value of this 5-mRNA signature was further verified in pan-cancer datasets. A nomogram was built with excellent performance and potential clinical application for prognosis. GSVA and GSVA revealed that metabolic pathways are distinct between high- and low-risk groups. Conclusions: We have established a 5-mRNA signature and a nomogram that can efficiently predict metastasis, recurrence and patient survival in HCC.

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Histologic Factors Associated With Need for Surgery in Patients With Pedunculated T1 Colorectal Carcinomas

Cited by 70 publications

References 44 publications

Poorly differentiated clusters in colorectal cancer: a current review and implications for future practice

Poorly differentiated clusters in colorectal cancer: a current review and implications for future practice

Clinical outcomes of submucosal colorectal cancer diagnosed after endoscopic resection: a focus on the need for surgery

Prognostic value of a metastasis-related gene signature in hepatocellular carcinoma

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