Histologic Study of Acute Vocal Fold Wound Healing after Corticosteroid Injection in a Rabbit Model

Abstract

The present results suggest that dexamethasone reduces collagen deposition during acute vocal fold wound healing.

Investigation of Experimental Wound Closure Techniques in Voice Microsurgery

“…Three of the more commonly used models in operative studies are rabbits (Thibeault, Gray et al 2002;Thibeault, Bless et al 2003;Branski, Rosen et al 2005;Carneiro and Scapini 2009;Campagnolo, Tsuji et al 2010), dogs (Garrett, Coleman et al 2000;Fleming, McGuff et al 2001;Rousseau, Hirano et al 2003;Karajanagi, Lopez-Guerra et al 2011) and pigs (Blakeslee, Banks et al 1995;Garrett, Coleman et al 2000;Jiang, Raviv et al 2001;Alipour and Jaiswal 2008;Fonseca, Malafaia et al 2010). …”

“…Branski et al (Branski, Rosen et al 2005) studied the healing process of rabbit vocal fold after injury, using a neonatal laryngoscope to access the vocal fold. Campagnolo et al (Campagnolo, Tsuji et al 2010) studied the healing effects of injectable corticosteroids after vocal fold surgery using a custom made laryngoscope for access.…”

“…Extensive work has focused on improving wound closure methods to minimize scar tissue formation, ranging from micro-suturing which allows for primary healing (Woo 1995;Tsuji, Nita et al 2009), to the use of tissue adhesives like fibrin glue (Bleach, Milford et al 1997;Flock 2005;Kitahara, Masuda et al 2005;Finck, Harmegnies et al 2010;Skodacek, Arnold et al 2011), and the use of chemical agents (Campagnolo, Tsuji et al 2010) like Mitomycin-C (Branski, Verdolini et al 2006;Fonseca, Malafaia et al 2010) or stem cells (Hong, Lee et al) to enhance the healing process of vocal fold wounds. However, various challenges faced in the execution of voice microsurgery add to the complexity of wound closure.…”

The Possibilities of Cell Technologies in the Treatment of Cicatricial Lesions of the Vocal Folds

“…Максимум клеточной инфильтрации наблюдается ко 2−3-м сут. На 3-й день отмечается ча-стичная эпителизация, к 5-му дню раневая поверхность полностью покрыта утолщенным эпителиальным слоем, появляется матрикс новообразованного коллагена [15,19,20]. Более плотный и неорганизованный коллаген образуется к 10-му дню.…”

Efeitos da injeção e reinjeção do fator de crescimento de hepatócito sobre a cicatrização de pregas vocais de coelhos

“…Inúmeros trabalhos na literatura descrevem a injeção de substâncias como opção para tratar a fibrose, tais como gelfoam (Schramm et al, 1978), Nakayama et al, 1993), colágeno (Ford et al, 1992(Ford et al, , 1995Remacle et al, 1999;Bjorck et al, 2002), gordura (Sataloff et al, 1997;Hsiung et al, 2000;Neuenschwander et al, 2001), combinação de gordura e fáscia (Hsiung et al, 2004), ácido hialurônico (Hallen et al, 1998(Hallen et al, , 1999Dahlqvist et al, 2004;Hertegard et al, 2006b), ácido hialurônico com colágeno 1999; Campagnolo et al, 2010), mitomicina-C (Garrett et al, 2001), células tronco mesenquimais humanas (Hertegard et al, 2006a), células tronco embrionárias humanas (Cedervall et al, 2007), entre outros.…”