Histological and Nuclear Medical Comparison of Inflammation After Hemostasis with Non‐Thermal Plasma and Thermal Coagulation

Abstract

The objective of this study is to examine the invasiveness of hemostasis by non‐thermal plasma (NTP) compared with hemostasis by thermal coagulation (TC). The inflammation recovery process after hemostasis by TC and NTP was compared by using histological methods and nuclear medical molecular imaging. The necrotic areas in the NTP group disappeared after 5 days, whereas they remained 15 days after hemostasis in the TC group. The accumulation of 2‐deoxy‐2‐[18F]fluoro‐d‐glucopyranose (18F‐FDG), which reflects the existence of inflammatory cells, was higher in the TC group than in the NTP group on day 15. Thus, this study indicates that hemostasis by NTP is less inflammatory than TC. This report is the first to evaluate inflammation that occurred after hemostasis with medical devices noninvasively.

Development and characterization of a 68Ga-labeled A20FMDV2 peptide probe for the PET imaging of αvβ6 integrin-positive pancreatic ductal adenocarcinoma

“…At 52 min after injection, a 15-min PET scan followed by a 5-min CT scan were performed using Triumph LabPET12/SPECT4/CT (TriFoil Imaging Inc., Chatsworth, CA, USA) under 2.5% isoflurane anesthesia. 25 Parameters for both scans and for image reconstruction were adjusted as per those used in a previous report. 26 After PET/CT imaging, the mice were killed, and each tumor was removed and frozen for further analysis.…”

Low temperature plasma equipment applied on surgical hemostasis and wound healings

“…Based on results from a series of basic studies in plasma science, we have succeeded in developing LTP coagulation equipment that has a minimal risk for burn injury by reducing the plasma current that flows through the tissue. ( 31 )…”

Plasma-activated interfaces for biomedical engineering

“…Moreover, they are effective in activating the immune system in the treatment of atopic dermatitis and relieving patients of pruritus [ 80 , 117 ]. Tissue regeneration has been observed from the treatment of facial skin to smooth wrinkles and blood vessels to speed up coagulation [ 77 , 78 , 81 ]. It is also important that little side effects have been observed [ 44 , 118 ] thereby boding well for clinical applications [ 119 , 120 ].…”