Histological changes during orthodontic tooth movement due to hyperbaric oxygen therapy

Brahmanta, Arya; Sutjipto, Sutjipto; Narmada, Ida Bagus

doi:10.20473/j.djmkg.v49.i2.p63-66

Cited by 4 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13 14 15 These biomarkers provide insight into osteogenesis and osteoclast genesis molecular and cellular biology in response to orthodontic mechanical pressures. In addition, parameters or biomarkers used to analyze in the included articles comprised AP), 16 17 collagen synthesis, 16 osteoblast, 18 osteoclast, 17 osteocyte, 19 type I collagen, 20 VEGF, 21 osteocalcin, 21 fibroblast, 18 matrix metalloproteinase-8 (MMP-8), 22 transforming growth factor (TGF)-β, 22 partial pressure of oxygen (pO 2 ), 16 partial pressure of carbon dioxide (pCO 2 ), 16 trabecular bone density, 23 24 teeth mobility, 25 PDL width, 18 number of blood vessels, 18 and TNF receptor associated factor 6 (TRAF-6). 17 From this perspective, it can be concluded that some other biomarkers involved in the orthodontic biological process might be further investigated.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Potential Use of Hyperbaric Oxygen Therapy in Orthodontic Treatment: A Systematic Review of Animal Studies

et al. 2022

View full text Add to dashboard Cite

Understanding the fundamental principles of tooth movement could reduce the duration of treatment and achieve a stable outcome, resulting in patient satisfaction. Hyperbaric oxygen therapy was a modality in which a patient inhaled 100% O2 while subjected to high atmospheric pressure. Hyperbaric oxygen therapy facilitated the supply of oxygen to the human body's organs and tissues and served a variety of applications, including patient care and wound treatment. This review article aimed to describe animal studies of the potential effects of hyperbaric oxygen therapy in orthodontic therapy. It was conducted using a systematic literature review method, including searching PubMed and Google Scholar for publications relevant to the research topics. The search was filtered to include only research on orthodontic treatment and hyperbaric oxygen therapy and was published in any year. Articles that did not specify biological components of orthodontic tooth movement (OTM) were excluded. The Preferred Reporting Items identified the papers for the Systematic Reviews and Meta-Analyses (PRISMA) strategy, which resulted in the selection of 11 publications. Hyperbaric oxygen therapy affected parameters of biomarkers representing the clinical, molecular, and cellular biology of bone formation and resorption in periodontal tissues in responding to orthodontic physical forces, including alkaline phosphatase, collagen synthesis, osteoblast, osteoclast, osteocyte, type I collagen, vascular endothelial growth factor, osteocalcin, fibroblast, matrix metalloproteinase-8, transforming growth factor-β, partial pressure of oxygen, partial pressure of carbon dioxide, trabecular bone density, and tooth mobility. Hyperbaric oxygen therapy induced an inflammatory response to follow OTM events during active orthodontic therapy. Hyperbaric oxygen therapy might play a role in the tissue healing process during passive treatment. Nonetheless, additional research should be conducted to establish the efficacy of hyperbaric oxygen therapy in orthodontics.

show abstract

Section: Discussionmentioning

confidence: 99%

“…25 The other studies used animals (Sprague-Dawley rats, 16 23 dogs, 24 guinea pigs, 18 19 21 42 and Cavia cobaya). 17 20 22 HBOT's effects got more investigated during inactive phase of orthodontic treatment. Only two studies described using HBOT in the passive phase to prevent orthodontic relapse.…”

Section: Discussionmentioning

confidence: 99%

Potential Use of Hyperbaric Oxygen Therapy in Orthodontic Treatment: A Systematic Review of Animal Studies

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In this experimental study, 25 male guinea pigs with an average age of (3  4 months) and weight around 300-400 g on average were randomly divided into equal groups. The guinea pigs were randomly assigned to three groups: the control group or group (-) with no HBOT treatment; the positive group (+) with only OTM, and the treatment group (P) with OTM and HBOT 2.4 ATA 3 × 30 minutes a day on days 8-14 and given HBOT for 7 days (Brahmanta et al, 2016a;2016b).…”

Section: The Remodeling Of Orthodontic Tooth Movement On Animal Model...mentioning

confidence: 99%

“…If the pressure is applied long enough to the teeth, there will be the remodeling of periodontal structure, including the alveolar bone. Related to the oxygen administration, vascularization performs an important role in the process of bone remodeling and as well as the oxygen pressure in it, which also contributes a shared role (Brahmanta et al, 2016b). The administration of mechanical force with orthodontic pressure to the periodontal ligament will also cause changes in blood vessels, both diameter and number of blood vessels, and transformations in the endothelium as a signal in tissue remodeling (Nareswari et al, 2019;Nugraha et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, there will be alveolar bone resorption, which requires the activity of osteoblasts and osteoclasts within the extracellular matrix (Narmada et al, 2019). To facilitate the mobility of these cells, an enzyme is needed to break down collagen, which is the largest component of the extracellular matrix, called collagenase (matrix metalloproteinase, MMP), for example, MMP-8 (Khrisnan and Davidovitch, 2006;Brahmanta et al, 2016a;2016b). Consequently, the expression of TGF-β and MMP-8 on OTM given HBOT is still not explained.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of hyperbaric oxygen 2.4 absolute atmospheres on transforming growth factor-β and matrix metalloproteinase-8 expression during orthodontic tooth movement in vivo

Brahmanta¹,

Prameswari²,

Handayani³

et al. 2021

J Pharm Pharmacogn Res

Self Cite

View full text Add to dashboard Cite

Context: Orthodontic force causes the compression of the periodontal ligament in inhibiting vascularization on the pressure side of orthodontic tooth movement (OTM), while on the opposite side, the periodontal ligament is stretched. Hyperbaric oxygen therapy (HBOT) can increase the dissolved oxygen in the blood, which can affect the tissue regeneration of the periodontal ligament. Aims: To evaluate the effect of HBO 2.4 absolute atmospheres (ATA) for 3 × 30 minutes with 5 minutes interval for 7 days as an adjuvant therapy to accelerate periodontal ligament remodeling during OTM in Cavia cobaya. Methods: The study was an experimental laboratory research with a completely randomized design. Twenty-four males C. cobaya were divided into three groups, (X1) as the control group, (X2) as the group with orthodontic force, and (X3) as the group with orthodontic force followed by HBO 2.4 ATA. Matrix Metalloproteinase (MMP)-8 and Transforming Growth Factor (TGF)-β expressions were measured by using immunohistochemistry. OTM was then examined by applying linear distance and analyzed by employing ratio test (p<0.05). Results: Ratio analysis shows HBO 2.4 ATA for 3 × 30 minutes once a day with 5 minutes intervals for 7 days has increased MMP-8 expressions in the pressure area and TGF-β in the tension area (p<0.05). Conclusions: HBO 2.4 ATA for 3 × 30 minutes once a day for 7 with 5 minutes intervals is able to effectively accelerate the periodontal ligament remodeling process expressed by the increased expression MMP-8, especially within the pressure area and TGF-β in the tension area.

show abstract

Stimulasi Pulsed Electromagnetic Field (PEMF) pada Osteogenesis Pergerakan Gigi Ortodonti

Maulana

Yueniwati

Lyrawati

et al. 2023

stoma

View full text Add to dashboard Cite

The prevalence of malocclusion and the need for orthodontic treatment in Indonesia is relatively very high. Orthodontic treatment that transmits mechanical forces to the periodontal ligament and alveolar bone cells can stimulate the periodontal ligament and alveolar bone remodeling. While this time, orthodontic treatment requires a long time, resulting in several adverse effects and discomfort. For this reason, a method that can accelerate orthodontic treatment is needed which aims to increase stability after active orthodontic treatment, to reduce the potential for relapse, and to accelerate retention time. Pulsed Electromagnetic Field (PEMF) stimulation is one of the methods that have this goal. This aim to study the stimulation mechanism of PEMF on the osteogenesis process of orthodontic tooth movement. Alveolar bone remodeling played an essential role in orthodontic tooth movement, is an active and dynamic process. The dynamic process depends on a balance between resorption and bone formation (osteogenesis). PEMF stimulation is a nonsurgical method that can promote osteogenesis through activation of Wnt signaling. Several studies showed that this method could accelerate retention time and orthodontic treatment. PEMF stimulated osteogenesis through activation of Wnt signaling in orthodontic tooth movement.

show abstract

Histological changes during orthodontic tooth movement due to hyperbaric oxygen therapy

Cited by 4 publications

References 10 publications

Potential Use of Hyperbaric Oxygen Therapy in Orthodontic Treatment: A Systematic Review of Animal Studies

Potential Use of Hyperbaric Oxygen Therapy in Orthodontic Treatment: A Systematic Review of Animal Studies

The effect of hyperbaric oxygen 2.4 absolute atmospheres on transforming growth factor-β and matrix metalloproteinase-8 expression during orthodontic tooth movement in vivo

Stimulasi Pulsed Electromagnetic Field (PEMF) pada Osteogenesis Pergerakan Gigi Ortodonti

Contact Info

Product

Resources

About