2015
DOI: 10.5352/jls.2015.25.12.1415
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Histological Changes in Reproductive Organs of Pubescent Male Mice in Response to ICI 182, 780 Treatment and Recovery of the Organs with Time

Abstract: ICI 182, 780 (ICI) has been used as an estrogen receptor inhibitor in several mammalian species. This study was conducted to observe histological changes in the reproductive system of pubescent male mice following ICI treatment, as well as to investigate the recovery of the organs over time. To accomplish this, ICI at 5 mg/0.1 ml of castor oil was subcutaneously injected into 5-week-old male mice once per week for 4 weeks. The mice were then randomly divided into no-recovery, 150-day recovery, and 300-day reco… Show more

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