Histological Changes in the Human Gallbladder Epithelium associated with Gallstones

Zaki, M. J.; Al-Refeidi,

doi:10.5001/omj.2009.55

Cited by 9 publications

(13 citation statements)

References 16 publications

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“…Kandung empedu yang mengandung batu berkembang menjadi kanker sebagai hasil dari iritasi terus-menerus, trauma, dan peradangan kronik. 13 Studi yang dilakukan oleh Mathur et al 17 mendapati semua perubahan yang terjadi pada mukosa kandung empedu berupa kolesistitis, hiperplasia, metaplasia, dan karsinoma lebih sering terlihat pada pasien dengan batu campuran. Pada kasus kanker kandung empedu, sekitar 88% (7 dari 8 pasien) memiliki batu campuran.…”

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“…Oleh karenanya, penelitian mengenai perubahan displasia dan keganasan yang berhubungan dengan penyakit batu kandung empedu sangat penting untuk mendapatkan pemahaman yang lebih detil dari penyakit batu kandung empedu. 13 Laitio telah meletakkan dasar pengertian mengenai tahapan patogenesis kanker kandung empedu. Metaplasia pada dinding kandung empedu yang berkembang menjadi displasia merupakan kunci dari kasinogenesis kandung empedu.…”

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Hubungan Antara Jenis Batu Dan Perubahan Mukosa Kandung Empedu Pada Pasien Batu Kandung Empedu

Kereh¹,

Lampus²,

Sapan³

et al. 2015

JBM

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This study aimed to analyze the relationship between gallstone and histopathological changes of gallbladder mucosa among patients with gallstones. Samples consisted of 38 patients with gallstones who were performed elective cholecystectomy either by laparoscopy or by laparotomy on them. Gallstones were analyzed macroscopically to determine the types of stones. Specimens of resected gallbladders were examined histopathologically to obtain the changes of gallbladder mucosa. The results showed that macroscopical analysis resulted in three types of gallstones: cholesterol stone (76.3%), pigmented stone (21.1%), and mixed stone 2.6%). Histopathologically, all resected speciments showed changes of gallbladder mucosa in the forms of chronic inflammation or associated with hyperplasia. There was no incidental cases of gallbladder cancer. An analysis of the relationship between the types of stones and the histopathological changes of gallbladder mucosa with the chi-square test showed an X2 value of 0.483 and a P value of 0.392. Conclusion: In this study, there was no relationship between the types of gallstones and the histopathological changes of gallbladder mucosa among patients with gallstone.Keywords: gallstone, cholecystectomy, gallbladder mucosaAbstrak: Penelitian ini bertujuan untuk menganalisis hubungan batu kandung empedu dengan perubahan mukosa kandung empedu pada pasien dengan batu kandung empedu. Sampel terdiri dari 38 pasien batu kandung empedu yang menjalani operasi elektif kolesistektomi, baik secara laparoskopik maupun secara terbuka. Batu kandung empedu dianalisis secara makroskopik untuk menentukan jenis batu. Spesimen reseksi kandung empedu diperiksa secara histopatologik untuk melihat ada tidaknya perubahan mukosa kandung empedu. Dari hasil analisis batu secara makroskopik didapatkan 3 jenis batu kandung empedu, yaitu batu kolesterol (76,3%), batu pigmen (21,1%), dan batu campuran (2,6%). Semua spesimen reseksi kandung empedu diperiksa secara histopatologik dan menunjukkan perubahan mukosa kandung empedu berupa radang kronis dan hiperplasia. Tidak terdapat penemuan secara insidental terhadap kanker kandung empedu. Analisis hubungan antara jenis batu kandung empedu dan perubahan mukosa kandung empedu dengan uji chi-square mendapatkan X2 = 0,483 dengan P = 0,392. Simpulan: Dalam penelitian ini tidak didapatkan hubungan antara jenis batu dan perubahan mukosa kandung empedu pada pasien dengan batu kandung empedu.Kata kunci: batu kandung empedu, kolesistektomi, mukosa kandung empedu

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Hubungan Antara Jenis Batu Dan Perubahan Mukosa Kandung Empedu Pada Pasien Batu Kandung Empedu

Kereh¹,

Lampus²,

Sapan³

et al. 2015

JBM

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“…Gall bladder dyskinesia resulting in bile stasis is considered as the main pathology responsible for gall stone formation. Three factors namely mucus, calcium and lipid act together to promote the nucleation of the stones [11] . Stones are categorized as cholesterol stones, pigment stones and the mixed stones according to their composition [12] .…”

Section: Introductionmentioning

confidence: 99%

“…Gall stones are responsible for the irritation of the columnar epithelium and is the main underlying cause for a number of histopathological changes like acute and chronic cholecystitis, cholesterolosis and pre-neoplastic conditions like metaplasia and dysplasia, ultimately culminating into the neoplasia [6,11,14] . That's why, patients with cholelithiasis need proper surveillance as most of the carcinoma of gall bladder are found in association of the stones [15,16] .…”

Section: Introductionmentioning

confidence: 99%

The spectrum of histopathological lesions in Gallbladder in cholecystectomy specimens

Gupta¹,

Faiz²,

Thakral³

et al. 2019

Int. J. Clin. Diagn. Pathol.

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Background: Gall bladder is very common organ to be affected by many pathological diseases which include wide spectrum of the lesions from congenital ones to inflammatory or premalignant and malignant lesions. Aim: Study the spectrum of histopathological lesions in gallbladder in Cholecystectomy specimens. Material and Methods: The study was conducted in the Department of Pathology, Muzaffarnagar Medical College, Muzaffarnagar. Total of 434 cholecystectomy specimen were studied. Result: Maximum cases (231/434 cases) were of chronic cholecystitis followed by acute cholecystitis (28 cases), eosinophilic cholecystitis (3 cases), cholesterolosis (31 cases), follicular cholecystitis (11 cases), xanthogranulomatous cholecystitis (9 cases) and one case each of mucocele and porcelain gall bladder. Metaplasia was seen in 83 cases (19.12%), dysplasia in 16 cases (3.68%) and malignancy in 5 cases (1.15%). Conclusion: Gall bladder with stones of prolonged duration associated with risk of premalignant and malignant conditions making histopathological examination necessary for timely recognization of lesion.

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“…1 Cholelithiasis is known to produce changes in the gallbladder mucosa ranging from acute cholecystitis, chronic cholecystitis, polyp, granulomatous cholecystitis, empyema, eosinophilic cholecystitis, metaplasia, hyperplasia and dysplasia to carcinoma. 3 The incidental detection of gallbladder cancer in routine cholecystectomy specimens is 0.3%-2%. Early clinical and radiological detection of carcinoma is difficult as only 40% cases present as solid intraluminal masses.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of AgNORs in gallbladder lesions

Kaushik¹,

Dattal²,

Gulati³

et al. 2017

Int J Res Med Sci

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Background: Quantification of argyrophillic nucleolar organizer regions (AgNORs) is a good indicator of cellular proliferation activity and is useful diagnostic tool to estimate the malignant potential of lesions in gallbladder. The aim of the present study was to study the AgNORs and assess their correlation with various lesions of the gallbladder.Methods: This study was conducted in the department of pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India. One hundred specimens of gall bladder lesions (50 cases chronic cholecystitis,30 cases epithelial hyperplasia and 20 cases of carcinoma) were study subjects. AgNOR staining was done on three micron thin sections of paraffin embedded tissue, as per the method of Crocker and Smith with safranin counterstain. The number of AgNORs, stained as black dots was counted in one hundred adjacent cells in different lesions.Results: Mean AgNOR count in chronic cholecystitis, epithelial hyperplasia and carcinoma was 2.44±0.31, 3.88±0.39 and 7.90±0.76 respectively. AgNOR counts in various lesions gradually increased from chronic cholecystitis to carcinoma and the increase was statistically significant (p<0.05).Conclusions: Despite inter-laboratory variations and lack of standardization of counts for a particular lesion, AgNOR technique is easy to perform, economical and reliable indicator of malignant potential of the gall bladder lesions, hence can be used in resource poor set up as an adjunct to histopathology.

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Histological Changes in the Human Gallbladder Epithelium associated with Gallstones

Cited by 9 publications

References 16 publications

Hubungan Antara Jenis Batu Dan Perubahan Mukosa Kandung Empedu Pada Pasien Batu Kandung Empedu

Hubungan Antara Jenis Batu Dan Perubahan Mukosa Kandung Empedu Pada Pasien Batu Kandung Empedu

The spectrum of histopathological lesions in Gallbladder in cholecystectomy specimens

Evaluation of AgNORs in gallbladder lesions

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