Histological changes of gastric mucosa after<i>Helicobacter pylori</i>eradication: A systematic review and meta-analysis

Kong, Yan; Yi, Honggang; Dai, Juncheng; Wei, Mu-Xin

doi:10.3748/wjg.v20.i19.5903

Cited by 105 publications

(73 citation statements)

References 46 publications

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“…Helicobacter pylori is the most common persistent bacterial infection which causes chronic inflammation of the inner lining of the stomach (9). These bacteria are the main factor of causing gastritis and other diseases related to gastritis such as peptic ulcer, stomach cancer and lymphoma, more over they are known to be connected with the increase risk of precancerous lesions such as chronic atrophic gastritis (AG), or gastric intestinal metaplasia (GIM), and cancer.…”

Section: Discussionmentioning

confidence: 99%

“…These bacteria are the main factor of causing gastritis and other diseases related to gastritis such as peptic ulcer, stomach cancer and lymphoma, more over they are known to be connected with the increase risk of precancerous lesions such as chronic atrophic gastritis (AG), or gastric intestinal metaplasia (GIM), and cancer. In addition, H. pylori can cause ischemic heart disease (IHD), chronic obstructive pulmonary disease (COPD), iron deficiency anemia (IDA), cerebral and neurological disease such as Alzheimer and migraine (9)(10)(11). Owing to the fact that patients with Down syndrome have genetic defects and physical problems, it seems vital to prevent the prevalence of infection among them; hence, early detection of the infection in such patients can prevent the spread of it (12).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Helicobacter pylori Infection in Patients With Down Syndrome and Mental Retardation

Fayaz

Gachkar

Roodsari

et al. 2014

Arch Clin Infect Dis

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Background: Clinical and epidemiological data indicate that Helicobacter pylori (H. pylori) are acquired during childhood and remains for the life time of the host. Patients with physical and mental disabilities may be particularly exposed to this microorganism, because of different dietary, abilities, living, and sanitary condition. Objectives: The current study aimed to investigate the prevalence of H. pylori infection among institutionalized patients with Down syndrome and mental retardation. Patients and Methods: Seventy five institutionalized patients with Down syndrome and mental retardation, with the age range of < 10 to 50 years were selected from welfare Center, an institute for caring mental retardation and Down syndrome patients. Seventy five out patients were also included as controls too. The control population was from the same geographical area as the study group, and had comparable socioeconomic features. Sanitary condition and personal hygiene of both the intervention and control groups were considered. Serum immunoglobulin G (IgG) produced in response to H. pylori infection was measured, with the Helori-test IgG with 92% sensitivity and 95% specificity; urea breath test (UBT) was also done for all. Results: The differences between the groups were compared by t-test and X 2 test. Seropositivity for H. pylori was significantly higher in patients with Down syndrome and mental retardation than in those of the control group (P < 0.001) as the socioeconomic features did not differ between the two groups, this can be a strong consideration of the validity of this comparison (the current study showed that out of 75 specimens, 41 cases were positive by Elisa test; accordingly, UBT test results were positive too). Conclusions: The current study indicated that H. pylori infection occurs at a higher rate in patients with Down syndrome and mental retardation. This may provide more reasons to control the transmission of H. pylori among them.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori Infection in Patients With Down Syndrome and Mental Retardation

Fayaz

Gachkar

Roodsari

et al. 2014

Arch Clin Infect Dis

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“…There have been some reports of metachronous gastric cancer development after the eradication of H. pylori [11,12,13]. In addition, some studies have investigated changes in the health of the gastric mucosa, such as the severities of atrophic gastritis and intestinal metaplasia, after H. pylori eradication [14,15,16,17]. Given these situations, it is highly required to predict the risk of cancer development in the era of H. pylori eradication and development of the better predictive biomarkers for gastric cancer is necessary.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Assessment of Gastric Xanthoma as Potential Predictive Marker of Gastric Cancer

Kitamura¹,

Muguruma²,

Okamoto³

et al. 2017

Digestion

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Background/Aims: Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. Methods: A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H. pylori infection, the prevalence rate of xanthomas, and the clinicopathological features of gastric cancer. Results: Gastric xanthomas were observed in 72.5% of early gastric cancer cases. Scores for gastritis and atrophy were significantly higher in the xanthoma-positive group than those in the xanthoma-negative group. A higher prevalence of differentiated-type adenocarcinoma was found in the xanthoma-positive group. Among the cases with multiple gastric xanthomas, the prevalence of males was significantly higher than that of females. Conclusion: A high prevalence rate of gastric xanthomas in gastric cancer cases was shown. Xanthomas were highly associated with age, the severities of gastritis and atrophy, and differentiated-type adenocarcinoma. Regardless of the eradication of H. pylori, xanthomas may be useful predictive markers for the development of differentiated-type adenocarcinoma.

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“…The incidence of intestinal metaplasia is lower in Western countries than in Asian countries (13). In a meta-analysis including 16 studies, authors observed a significant resolution in atrophic gastritis at both the antrum and corpus following H. pylori treatment (14).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of intestinal metaplasia associated with alkaline reflux gastritis and Helicobacter pylori in patients without gastric surgery

Erdoğan¹,

Aksakal²

2018

J Turgut Ozal Med Cent

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Aim: Alkaline reflux gastritis is a term used for gastric mucosa damage due to reflux of duodenal and pancreatic content into stomach. In addition to many histopathological changes caused by alkaline reflux gastritis, the relationship of alkaline reflux gastritis with intestinal metaplasia is also important. Gastric intestinal metaplasia is a precancerous lesion that requires a follow-up protocol. Material and Methods:This study included 1005 patients who underwent esophagogastroduodenoscopy and were diagnosed with alkaline reflux gastritis at Endoscopy Unit of Gastroenterology Department of Karabük University, Medical School between January 2013 and January 2016. Results: When the data of these patients were retrospectively reviewed, intestinal metaplasia was detected in 203 patients (20.2%), whereas Helicobacter pylori was detected in 466 patients (46.4%). There was pyloric dysfunction in 359 patients (35.7%) but 646 patients (64.3%) did not have pyloric dysfunction. Conclusion: In our study, it was found that there was an increase in the frequency of intestinal metaplasia in patients with alkaline reflux gastritis who had increased with age, male gender and Helicobacter pylori. This was a retrospective study indicating the association of H. pylori with intestinal metaplasia in patients with alkaline reflux gastritis. We think that there is a need for further prospective studies to investigate the presence of intestinal metaplasia in patients with alkaline reflux gastritis

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Histological changes of gastric mucosa afterHelicobacter pylorieradication: A systematic review and meta-analysis

Abstract: H. pylori eradication strongly correlates with improvement in IM in the antrum and GA in the corpus and antrum of the stomach.

Cited by 105 publications

References 46 publications

Prevalence of Helicobacter pylori Infection in Patients With Down Syndrome and Mental Retardation

Prevalence of Helicobacter pylori Infection in Patients With Down Syndrome and Mental Retardation

Clinicopathological Assessment of Gastric Xanthoma as Potential Predictive Marker of Gastric Cancer

Evaluation of intestinal metaplasia associated with alkaline reflux gastritis and Helicobacter pylori in patients without gastric surgery

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