Histological characteristics of early‐stage oral tongue cancer in young versus older patients: A multicenter matched‐pair analysis

Bello, Ibrahim O.; Almangush, Alhadi; Heikkinen, Ilkka; Haglund, Caj; Coletta, Ricardo D.; Kowalski, Luiz Paulo; Mäkitie, Antti; Nieminen, Pentti; Leivo, Ilmo; Salo, Tuula

doi:10.1111/odi.13288

Cited by 14 publications

(10 citation statements)

References 19 publications

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“…In young adults, the role of prognostic factors such as genetic or histopathological alterations has been studied 33‐35 . In this regard, the discussion has focused on the role of unknown risk and prognostic factors in young patients with OTSCC.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

et al. 2021

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While evidence suggests an increasing incidence of tongue cancer in young adults, published findings regarding the prognostic role of age at diagnosis are inconsistent. We performed a meta‐analysis of the literature to highlight key points that might help in understanding the association between age of oral tongue cancer patients at diagnosis and their prognosis. According to age at diagnosis, a systematic literature review of all published cohort studies assessing the recurrence risks and mortality associated with tongue cancer was conducted. We compared the risk estimates between patients aged >45 years and those aged <45 years at diagnosis. Random‐effects models were used to calculate summary relative risk estimates (SRRs) according to different clinical outcomes and sources of between‐study heterogeneity (I2) and bias. We included 31 independent cohort studies published between 1989 and 2019; these studies included a total of 28,288 patients. When risk estimations were not adjusted for confounders, no significant association was found between age at diagnosis and overall survival (OS). Conversely, after adjustment for confounders, older age at diagnosis was associated with a significantly increased risk of mortality. The difference between SRRs for adjusted and unadjusted estimates was significant (p < 0.01). Younger patients had a significantly higher risk of local recurrence. Younger patients with oral tongue cancer have better OS but a greater risk of recurrence than older patients. These findings should be validated in a large prospective cohort study which considers all confounders and prognostic factors.

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Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

et al. 2021

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“…The incidence of OSCC has increased in many countries, especially in younger individuals, but whether young and old patients with OSCC have a different prognosis is controversial [2]. Recent studies have revealed no significant differences in tumor stage or grade in the comparisons of the characteristics of OSCC in young and old patients [3][4][5]. Therefore, the discovery of factors that facilitate OSCC prognosis is one of the key challenges that we need to overcome.…”

Section: Introductionmentioning

confidence: 99%

Impact of Preoperative Low Prognostic Nutritional Index and High Intramuscular Adipose Tissue Content on Outcomes of Patients with Oral Squamous Cell Carcinoma

Yoshimura

Suzuki

Takayama

et al. 2020

Cancers

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The impact of preoperative malnutrition and sarcopenia on survival in oral squamous cell carcinoma (OSCC) patients remains controversial. We investigated the effects of the preoperative nutritional status and abnormalities in body composition on the mortality of OSCC patients. A retrospective study involving 103 patients with OSCC was conducted. Disease-specific survival (DSS) according to the preoperative psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC) was evaluated. Univariate and multivariate analyses were performed to determine the predictive performance of the covariates with respect to DSS. The DSS rate in patients with high IMAC and low PMI was significantly lower than that in controls. Multivariate analysis revealed that a low preoperative Prognostic Nutritional Index (PNI) and high IMAC were independent risk factors. We demonstrated that preoperative malnutrition and abnormal body composition, such as preoperative skeletal muscle quality, are associated with DSS in OSCC patients. Our study suggests that the evaluation of preoperative malnutrition and skeletal muscle quality would be useful for predicting mortality in patients with OSCC.

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“…This result supports the previous study that compared the clinicopathology of early stage OTSCC between young and elderly adults. [ 16 ]…”

Section: Resultsmentioning

confidence: 99%

Multicenter retrospective analysis of clinicopathological features and prognosis of oral tongue squamous cell carcinoma in adolescent and young adult patients

et al. 2021

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The aim of this study is to report the differences in clinicopathological features of oral tongue squamous cell carcinoma (OTSCC) and survival between adolescent and young adult (AYA) patients and elderly patients and to find the prognosticators. The medical records of 101 AYA patients and 175 control patients with OTSCC who underwent surgery were reviewed. Variables related to prognosis and their clinicopathological associations were analyzed. The 5-year overall survival (5y-OS) rates of AYA and control patients with stage I and II OTSCC were 94.4% and 89.6% (P = .353), respectively, and their 5-year disease-free survival (5y-DFS) rates were 82.0% and 76.6%, respectively (P = .476). The 5y-OS rates of patients with stages III and IV OTSCC were 83.3% and 66.7% (P = .333), respectively, and their 5y-DFS rates were 75.0% and 57.1% (P = .335), respectively. Logistic regression analysis revealed that there was no significant clinicopathological difference in AYA and control group. Furthermore, there was no significant difference in 5y-OS rates between patients who underwent elective neck dissection (END) and those who underwent therapeutic neck dissection (TND) in both group (P = 0.717 and 0.688). Overall, the present study revealed the clinicopathological features and prognosis of OTSCC were similar in AYA patients and elderly patients. Moreover, as there was no significant difference in OS between patients who underwent END and those who underwent TND in AYA and control groups, our results suggest that the indication for END in AYA patients with clinical N0 OTSCC is similar to that for elderly patients.Abbreviations: 5y-OS = 5-year overall survival, AYA = adolescent and young adult, CLNM = cervical lymph node metastasis, DFS = disease-free survival, END = elective neck dissection, OCLNM = occult cervical lymph node metastasis, OS = overall survival, OSCC = oral squamous cell carcinoma, OTSCC = oral tongue squamous cell carcinoma, SCC = squamous cell carcinoma, TND = therapeutic neck dissection.

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Histological characteristics of early‐stage oral tongue cancer in young versus older patients: A multicenter matched‐pair analysis

Cited by 14 publications

References 19 publications

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

Impact of Preoperative Low Prognostic Nutritional Index and High Intramuscular Adipose Tissue Content on Outcomes of Patients with Oral Squamous Cell Carcinoma

Multicenter retrospective analysis of clinicopathological features and prognosis of oral tongue squamous cell carcinoma in adolescent and young adult patients

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