Histological Observations One Year After Mechanochemical Endovenous Ablation of the Great Saphenous Vein

Eekeren, Ramon R.J.P. van; Hillebrands, Jan-Luuk; Sloot, Kim van der; Vries, Jean‐Paul P.M. de; Zeebregts, Clark J.; Reijnen, Michel M.P.J.

doi:10.1583/13-4588mr.1

Cited by 22 publications

(15 citation statements)

References 9 publications

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“…A total of 28% of patients presented with small hematomas, 17% had local skin hardening, and 18% felt discomfort for more than a week after the procedure. High effectiveness of this method over follow-up periods ranging from 6 to 24 months has been confirmed in several other studies [15][16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 59%

Application of endovenous mechanochemical ablation (MOCA) with Flebogrif™ to treat varicose veins of the lower extremities: a single center experience over 3 months of observation

Zubilewicz

Terlecki

et al. 2017

Acta Angiologica

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Section: Discussionmentioning

confidence: 59%

Application of endovenous mechanochemical ablation (MOCA) with Flebogrif™ to treat varicose veins of the lower extremities: a single center experience over 3 months of observation

Zubilewicz

Terlecki

et al. 2017

Acta Angiologica

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“…One of MOCA device is ClariVein (Merit Medical, South Jordan, Utah) that combines mechanical injury to the venous endothelium using a rotating wire with simultaneous delivery and dispersion of a liquid sclerosant [5]. The liquid sclerosant causes irreversible damage to the cellular membranes of the endothelium, resulting in the fibrosis of veins [6]. Another technique to produce a nontumescent sclerosantassisted ablation is by means of Flebogrif (Balton, Poland), a device that is scratching the endothelium lining by a dedicated catheter.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Occlusion Chemically Assisted Ablation (MOCA) for Saphenous Vein Insufficiency: A Meta-Analysis of a Randomized Trial

Nugroho

Wardhana²,

Ghea³

2020

International Journal of Vascular Medicine

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Purpose. A previous meta-analysis has conducted nonrandomized trials for mechanochemical ablation (MOCA). Since medium-term follow-up data from randomized clinical trials (RCTs) are becoming available, we chose to perform a meta-analysis of RCTs to assess the efficacy and safety of MOCA for saphenous vein insufficiency. Methods. A systematic search of all RCTs comparing the anatomical success of MOCA for saphenous vein insufficiency to thermal ablation was performed using the PubMed and Cochrane Library databases. We employed the Mantel-Haenszel random-effects meta-analysis of outcomes using RevMan 5.3. Results. Four studies (615 patients) were included in this meta-analysis. The MOCA group had 93.4% and 84.5%, whereas the thermal ablation group had 95.8% and 94.8% of anatomical success rate at 1 month (short-term) and a period of more than 6 months but less than 1-year follow-up (mid-term), respectively. According to intention-to-treat analysis, there were similar anatomical successes in MOCA and thermal ablation groups at the short-term follow-up (low-quality evidence; relative risk RR=0.98 (95% CI, 0.94–1.03); P=0.44; I2=53%). The estimated effect of MOCA on anatomical success showed a statistically significant reduction at the mid-term follow-up (moderate-quality evidence; RR=0.89 (95% CI, 0.84–0.95); P=0.0002; I2=0%). MOCA had fewer incidence of nerve injury, deep vein thrombosis, and skin burns compared to the thermal ablation procedure (low-quality evidence; RR=0.33 (95% CI, 0.09–1.28); P=0.11; I2=0%). Conclusion. MOCA offered fewer major complications but lesser anatomical success at the period of more than 6 months but less than 1-year follow-up than thermal ablation. Trial Registration. This trial is registered with UMIN Clinical Trial Registry (UMIN ID 000036727).

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“…These together lead to occlusion of the vein. 39 The procedure is associated with faster recovery and less post-procedure pain and discomfort. 40 The procedure has several advantages over other ablative techniques, including (a) reduced pain, bruising and discomfort, (b) no tumescent anesthesia, (c) no risk of nerve and skin damage, and (d) rapid return to regular activity.…”

Section: Mechanochemical Endovenous Ablationmentioning

confidence: 99%

“…42 MOCA has shown a closure rate of 87 to 96%. 39,43 A randomized controlled trial comparing MOCA and RFA showed a closure rate of 92% at 4 weeks. 44 Tang et al reported no difference in occlusion while treating GSV and SSV.…”

Section: Mechanochemical Endovenous Ablationmentioning

confidence: 99%

Endovascular Management of Varicose Veins: A Review of Literature

Singhal¹,

Uthappa²

2019

J Clin Interv Radiol ISVIR

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Venous insufficiency of the lower limb is a common condition characterized by a spectrum of symptoms, including bulging leg veins, pain, swelling, and ulceration. Various treatment options are available; however, the newer endovascular options are easy, highly effective, safe, and quick in relieving symptoms. Endovascular treatment options include thermal ablation, mechanicochemical ablation, and foam sclerotherapy. This review article briefly describes various scoring systems used in varicose veins, the role of imaging, different management techniques, and guidelines proposed in the management of this condition. AbstractKeywords ► varicose vein ► intervention ► radiology

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Histological Observations One Year After Mechanochemical Endovenous Ablation of the Great Saphenous Vein

Abstract: MOCA is a novel endovenous treatment modality for saphenous vein insufficiency. Results of MOCA on the cellular level are essential to optimize treatment.

Cited by 22 publications

References 9 publications

Application of endovenous mechanochemical ablation (MOCA) with Flebogrif™ to treat varicose veins of the lower extremities: a single center experience over 3 months of observation

Application of endovenous mechanochemical ablation (MOCA) with Flebogrif™ to treat varicose veins of the lower extremities: a single center experience over 3 months of observation

Mechanical Occlusion Chemically Assisted Ablation (MOCA) for Saphenous Vein Insufficiency: A Meta-Analysis of a Randomized Trial

Endovascular Management of Varicose Veins: A Review of Literature

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