Histological Study of the Effect of Induced Diabetes on the Zona Glomerulosa of the Adrenal Cortex of Adult Male Albino Rat

El-Feky, Hend Ali; Salah, Adel; Hussein, Youssef; Sabry, Mohammed

doi:10.1097/00767537-201003000-00003

Cited by 8 publications

(6 citation statements)

References 2 publications

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“…Thus, plasma aldosterone concentrations increase. However, plasma aldosterone levels were found to decrease 4 weeks after STZ injection (El-Feky et al, 2010). The cell sizes ofproximal convoluted tubule increase, the basement membrane thickens, and lipid peroxidation occurs, resulted in decreased glucose reabsorption (Lanlua et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Modifications of Adrenal Gland Ultrastructure in Streptozotocin-Induced Diabetic Model Rats

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Modifications of Adrenal Gland Ultrastructure in Streptozotocin-Induced Diabetic Model Rats

et al. 2021

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“…Birem 15 et al found 202% higher levels of ACTH in palm olive receiving animals compared to control in study of 7 months ,they found a positive correlation between ACTH levels and HDL -cholesterol. Another study 16 (EL-Feky etal, 2010) also observed that fat which enter the adrenal gland causes increase in lipid rich cells in zona fasciculata and reticularis. L Arginine used along with butter and corn oil was able to decrease the levels of ACTH but the difference was not significant among the two types of fat.…”

Section: Sections Of Adrenal Cortices Of Groupmentioning

confidence: 91%

Concomitant Use Of L-arginine With High Butter And Corn Oil Diet Prevent Their Harmful Effects On Adrenocortical Cells Of Albino Rats

Quddus¹,

Samir²,

Waqar³

et al. 2017

J. Bahria Uni. Med. Dent. Coll.

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Objective: To compare the bichemical and morphological effects of L -Arginine against the changes caused by butter and corn oil supplementation Study design: A prospective experimental study Place: Department of Anatomy BMSI, JPMC Duration: August to October 2008. Methodology:Male Albino rats weighing 200 - 240gm were selected and divided into 5 groups. Group ‘CL’ received standard laboratory diet. Group ‘Bu’ received 20% added unsalted butter in diet. Group ‘Co’ received 20% added corn oil in diet. Group ‘BuAr’ received 20% Butter with L-Arginine 300mg /kg body weight /day orally .Group‘CoAr’ received 20%corn oil along with L-Arginine 300mg/kg body weight/day orally. On completion of study period that is 4 weeks, animals were sacrifised. Blood was drawn for hormonal assays. Adrenal glands were removed and fixed in buffered neutral formalin. Right adrenals were processed and sectioned at4 µm thickness to be stained with Mallory trichrome stain to visualize blood vessel. Left adrenalswere sectioned with cryostat in 10µm sections and stained with Oil red O to visualize fat in cells. Results:Highly significant and moderately significant decrease observed in ACTH (Adrenocorticotrophic hormone)levels in Group BuArand CoAr when compared to Bu and Co respectively; insignificant difference was found between BuAr&CoAr. Moderately significant and significant decrease observed in corticosterone levels in Group BuAr and CoAr when compared to Buand Co respectively. Insignificant difference was found between BuAr and CoAr . Mallory trichrome stained section showed less dilated blood vessels in BuAr&CoAr compared to Bu & Co respectively, while difference among the former two was not remarkable. Oil red O stained sections showed less densely packed fat globules in group BuAr&CoAr compared to Bu and Co respectively. Difference between BuAr&CoAr was not marked. Conclusion: Butter has more stimulatory effect on adrenal cortical cells but the comparison with corn oil is not statistically significant except for ACTH levels. L Arginine seems to be effective in lowering the levels of stress hormones, fat accumulation and vasodilatation when given along with corn oil and butter oil.

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“…Therefore, it is important that efficient methods for the management and prevention of DM and its complications be identified (6). It is known that induction of experimental diabetes can be caused by chemical destruction or surgical removal of part of the beta cells of the pancreas, by feeding with high-fat and high-sugar diets, and by drugs such as streptozotocin (STZ) and alloxan (7). The pancreatic beta-cell toxin streptozotocin (STZ) causes rapid and irreversible necrosis in these cells.…”

Section: Introductionmentioning

confidence: 99%

“…The pancreatic beta-cell toxin streptozotocin (STZ) causes rapid and irreversible necrosis in these cells. The mechanism of STZ-induced cell injury includes increased reactive oxygen species generation, lipid peroxidation, protein oxidation, and DNA damage that results in cell death (8), producing an insulin deficiency similar to that in human diabetes type I (7).…”

Section: Introductionmentioning

confidence: 99%

Melatonin ameliorates the adrenal and pancreatic alterations in streptozotocin-induced diabetic rats: Clinical, biochemical, and descriptive histopathological studies

et al. 2022

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Previous studies have demonstrated the beneficial effects of melatonin in diabetic rats. However, limited studies have been conducted on the potential effects of melatonin on the descriptive histopathological and morphometric findings in different compartments of the adrenal glands in diabetic animal models. In this study, using a streptozotocin (STZ)-induced diabetic rat model, we sought to examine histological alterations in the pancreas and adrenal glands and observe the effect of the administration of melatonin on the histopathology and morphology of the pancreas and the adrenal gland cortex and medulla that are altered by STZ-induced hyperglycemia. Rats were randomly assigned to four different groups: Group I, normal control; Group II, melatonin group (MT) (10 mg/kg/day); Group III, (diabetic STZ group), and Group IV, diabetic (STZ) + melatonin group (MT). Throughout the experiment, the animals' fasting blood sugar levels were measured. Blood was obtained to determine the animals' cumulative blood sugar levels after sacrification. For histological and morphometrical evaluations, the pancreatic and adrenal gland tissues were dissected and processed. Our results showed that diabetic rats receiving melatonin significantly (P < 0.05) improved their fasting blood sugar and cumulative blood sugar levels compared to the diabetic group not receiving melatonin. Furthermore, histopathological examinations of the pancreatic and adrenal tissues of the diabetic rats indicated the occurrence of severe histopathological and morphometric changes. Morphometric analysis of the adrenals indicated a significant increase (P < 0.05) in the thickness of the cortex zones [zona glomerulosa (ZG), zona fasciculata (ZF), and zona reticularis (ZR)] for the diabetic STZ group compared with other groups, and a significant decrease (P < 0.05) in the diameter of the in adrenal gland medullas in the diabetic STZ rats compared to the other groups. Furthermore, treatment with melatonin restored these changes in both the pancreatic and adrenal gland tissues and produced a significant (P < 0.05) improvement in the cortex and medulla thickness compared to the untreated diabetic rats. Overall, melatonin significantly reduced the hyperglycemic levels of glucose in diabetic rats and reversed the majority of histopathological alterations in the tissues of the pancreas and adrenals, demonstrating its anti-diabetic activity.

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Histological Study of the Effect of Induced Diabetes on the Zona Glomerulosa of the Adrenal Cortex of Adult Male Albino Rat

Cited by 8 publications

References 2 publications

Modifications of Adrenal Gland Ultrastructure in Streptozotocin-Induced Diabetic Model Rats

Modifications of Adrenal Gland Ultrastructure in Streptozotocin-Induced Diabetic Model Rats

Concomitant Use Of L-arginine With High Butter And Corn Oil Diet Prevent Their Harmful Effects On Adrenocortical Cells Of Albino Rats

Melatonin ameliorates the adrenal and pancreatic alterations in streptozotocin-induced diabetic rats: Clinical, biochemical, and descriptive histopathological studies

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