Histological study on the possible protective effect of pentoxifylline on pancreatic acini of l-arginine-induced acute pancreatitis in adult male albino rats

Soliman, Mervat M.; Kefafy, Maisa A; Mansour, Magda; Ali, Amira Fahmy; Esa, Walaa Abdellah Ismail Ibrahim

doi:10.4103/1110-2098.149789

Cited by 5 publications

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“…These findings were in agreement with the results of previous studies which reported these histo-pathological changes after 1 day of induction of AP [19,22,44]. According to Nevalainen and Aho [31], oedema is the most common denominator of AP induced by any method, and reflects inflammatory mechanisms.…”

Section: Discussionsupporting

confidence: 93%

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

Sadek

Khattab

2017

Folia Morphol

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Background: Acute pancreatitis (AP) is an inflammatory disease that has an incre- Materials and methods: Thirty-six adult male albino rats were used in this study. Animals were divided into four groups; Control group (Group A; n = 6), Mel group (Group B; n = 6), L-arg group (Group C; n = 12) receiving two doses of L-arg injection with 1 h interval in-between, and L-arg+Mel group (Group D; n = 12) receiving Mel 1 h after each L-arg injection. 24 h after the second L-arg injection, the serum levels of amylase (AM), lipase (LP), interleukin-6 (IL-6) and (Folia Morphol 2017; 76, 1: 66-73)

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Section: Discussionsupporting

confidence: 93%

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

Sadek

Khattab

2017

Folia Morphol

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The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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The possible protective effect of luteolin on cardiovascular and hepatic changes in metabolic syndrome rat model

Fikry,

Saleh,

Sadek

et al. 2024

Cell Tissue Res

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Histological study on the possible protective effect of pentoxifylline on pancreatic acini of l-arginine-induced acute pancreatitis in adult male albino rats

Cited by 5 publications

References 0 publications

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

The protective role of melatonin on L-arginine-induced acute pancreatitis in adult male albino rats

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

The possible protective effect of luteolin on cardiovascular and hepatic changes in metabolic syndrome rat model

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