1991
DOI: 10.1136/jcp.44.3.219
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Histometric studies on cellular infiltrates of tuberculin tests in patients with sarcoidosis.

Abstract: The density and microanatomical location of CD4 and CD8 lymphocytes and of monocytes/macrophages at the site of a tuberculin test were measured in 13 patients with sarcoidosis, and the results were compared with those seen in a group of healthy controls. The cellular infiltrate was significantly reduced in the sarcoid subjects compared with the controls for all cell phenotypes studied; the ratio of CD4 positive:CD8 positive lymphocytes was significantly increased in the sarcoid group. Clinically negative react… Show more

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Cited by 4 publications
(2 citation statements)
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“…Several articles report this for patients with altered immune conditions: cancer (1)(2)(3)(4)(5), viral infections (6-9), Whipple's disease (10), mycosis fungoides (8,(11)(12)(13)(14) and sarcoidosis (15)(16)(17)(18)(19). These findings are referred to as skin anergy, a faulty cellular immune response and the opposite of allergy.…”
Section: Examples Of Skin Hyporeactivitymentioning
confidence: 99%
See 1 more Smart Citation
“…Several articles report this for patients with altered immune conditions: cancer (1)(2)(3)(4)(5), viral infections (6-9), Whipple's disease (10), mycosis fungoides (8,(11)(12)(13)(14) and sarcoidosis (15)(16)(17)(18)(19). These findings are referred to as skin anergy, a faulty cellular immune response and the opposite of allergy.…”
Section: Examples Of Skin Hyporeactivitymentioning
confidence: 99%
“…Prior to a single application of a selected contact Table 1. Observations of skin hyporeactivity/anergy Observations of skin hyporeactivity/anergy UV radiation (13-14, 26, 28) corticosteroid therapy (23)(24)(25)(26) immunomodulator treatment (22,(26)(27) sarcoidosis (15)(16)(17)(18)(19) cancer (1-5) viral infection (7), HIV (6), measles (8-9) Whipple's (10) mycosis fungoides (11)(12)(13)(14) allergen under a Finn Chamber for 24 h, the Ginkgo formulation was applied to intact skin 2¿ daily for 2 weeks. Visual scoring was performed 2 and 3 days after patch removal.…”
Section: Examples Of Skin Hyporeactivitymentioning
confidence: 99%