Histomorphological and Functional Features of the Eutopic Endometrium in Patients with Ovarian Endometriosis After Surgery—a Clinical Study

Mikhaleva, L.M.; Solomatina, A.A.; Ap, Milovanov; Beeraka, Narasimha M; Khovanskaya, T.N.; Chabieva, L.B.; Mikhalev, S.A.; Gracheva, N.A.; Chigray, L.V.; Beylerli, Ozal; Patsap, Olga I.; Aliev, Gjumrakch

doi:10.1007/s43032-021-00508-3

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…Studies on different cancer cell types, including breast ( 108 , 205 – 208 ), melanoma ( 117 ), cervical, and ovarian cancers ( 209 ), have shown that anastasis confers new traits upon cancer cells, such as increased drug resistance and migration ( 172 , 173 , 201 – 204 , 210 ). For instance, anastatic breast and cervical cancer cells are associated with enhanced chemoresistance and migration capabilities ( 203 ).…”

Section: Need For Investigating the Interplay Between Anastasis Ferro...mentioning

confidence: 99%

Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

Cao,

Lu,

Beeraka

et al. 2024

Front. Immunol.

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Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer membrane rupture, affecting mitochondrial function and cellular fate. Recent reports have described the intrinsic cellular iron metabolism and its intricate connection to ferroptosis, a significant kind of cell death characterized by iron dependence and oxidative stress regulation. Furthermore, updated molecular insights have elucidated the significance of mitochondria in ferroptosis and its implications in various cancers. In the context of cancer therapy, understanding the dual role of anastasis and ferroptosis in chemoresistance is crucial. Targeting the molecular pathways involved in anastasis may enhance the efficacy of ferroptosis inducers, providing a synergistic approach to overcome chemoresistance. Research into how DNA damage response (DDR) proteins, metabolic changes, and redox states interact during anastasis and ferroptosis can offer new insights into designing combinatorial therapeutic regimens against several cancers associated with stemness. These treatments could potentially inhibit anastasis while simultaneously inducing ferroptosis, thereby reducing the likelihood of cancer cells evading death and developing resistance to chemotherapy. The objective of this study is to explore the intricate interplay between anastasis, ferroptosis, EMT and chemoresistance, and immunotherapeutics to better understand their collective impact on cancer therapy outcomes. We searched public research databases including google scholar, PubMed, relemed, and the national library of medicine related to this topic. In this review, we discussed the interplay between the tricarboxylic acid cycle and glycolysis implicated in modulating ferroptosis, adding complexity to its regulatory mechanisms. Additionally, the regulatory role of reactive oxygen species (ROS) and the electron transport chain (ETC) in ferroptosis has garnered significant attention. Lipid metabolism, particularly involving GPX4 and System Xc- plays a significant role in both the progression of ferroptosis and cancer. There is a need to investigate the intricate interplay between anastasis, ferroptosis, and chemoresistance to better understand cancer therapy clinical outcomes. Integrating anastasis, and ferroptosis into strategies targeting chemoresistance and exploring its potential synergy with immunotherapy represent promising avenues for advancing chemoresistant cancer treatment. Understanding the intricate interplay among mitochondria, anastasis, ROS, and ferroptosis is vital in oncology, potentially revolutionizing personalized cancer treatment and drug development.

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Section: Need For Investigating the Interplay Between Anastasis Ferro...mentioning

confidence: 99%

Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

Cao,

Lu,

Beeraka

et al. 2024

Front. Immunol.

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“…For less than 50-year-old patients with early BC, the removal of ovaries ( 241 ) substantially increased long-term survival in the absence of follow-up chemotherapy. The Early BC Trialists’ Collaborative Group reported 130 deaths and 153 recurrences among 2,102 patients (<50 years old).…”

Section: Obesity-linked Effects On Breast Cancer Incidence Treatment ...mentioning

confidence: 99%

Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers

et al. 2022

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Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC) growth and metastasis. Leptin, adiponectin, estrogen, and several pro-inflammatory cytokines are involved in the development of obesity-driven BC through the activation of multiple oncogenic and pro-inflammatory pathways. The aim of this study was to assess the reported mechanisms of obesity-induced breast carcinogenesis and effectiveness of conventional and complementary BC therapies. We screened published original articles, reviews, and meta-analyses that addressed the involvement of obesity-related signaling mechanisms in BC development, BC treatment/prevention approaches, and posttreatment complications. PubMed, Medline, eMedicine, National Library of Medicine (NLM), and ReleMed databases were used to retrieve relevant studies using a set of keywords, including “obesity,” “oncogenic signaling pathways,” “inflammation,” “surgery,” “radiotherapy,” “conventional therapies,” and “diet.” Multiple studies indicated that effective BC treatment requires the involvement of diet- and exercise-based approaches in obese postmenopausal women. Furthermore, active lifestyle and diet-related interventions improved the patients’ overall quality of life and minimized adverse side effects after traditional BC treatment, including postsurgical lymphedema, post-chemo nausea, vomiting, and fatigue. Further investigation of beneficial effects of diet and physical activity may help improve obesity-linked cancer therapies.

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“…However, there are no current clinical data showing that surgical treatment of EMS can improve endometrial receptivity. Mikhaleva et al performed endometrial biopsies on EMS patients, who underwent surgical resection of the ectopic ovarian foci after 6 and 12 months and found that the ER and PR were extensively expressed in the proliferative and secretory endometrium, with the impaired formation of pinopodia in the secretory phase [ 103 ]. Thus, surgery might not be an option to overcome the bio-molecular alterations of the endometrium due to EMS.…”

Section: Intervention Strategies To Improve Endometrial Receptivitymentioning

confidence: 99%

Towards a Better Understanding of Endometriosis-Related Infertility: A Review on How Endometriosis Affects Endometrial Receptivity

Shan

Wang

2023

Biomolecules

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Endometriosis is the most common cause of infertility. Endometrial receptivity has been suggested to contribute to infertility and poor reproductive outcomes in affected women. Even though experimental and clinical data suggest that the endometrium differs in women with endometriosis, the pathogenesis of impaired endometrial receptivity remains incomplete. Therefore, this review summarizes the potential mechanisms that affect endometrial function and contribute to implantation failure. Contemporary data regarding hormone imbalance, inflammation, and immunoregulatory dysfunction will be reviewed here. In addition, genetic, epigenetic, glycosylation, metabolism and microRNA in endometriosis-related infertility/subfertility will be summarized. We provide a brief discussion and perspectives on their future clinical implications in the diagnosis and therapy to improve endometrial function in affected women.

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Histomorphological and Functional Features of the Eutopic Endometrium in Patients with Ovarian Endometriosis After Surgery—a Clinical Study

Cited by 6 publications

References 37 publications

Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers

Towards a Better Understanding of Endometriosis-Related Infertility: A Review on How Endometriosis Affects Endometrial Receptivity

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