Histomorphological changes in induced benign prostatic hyperplasia with exogenous testosterone and estradiol in adult male rats treated with aqueous ethanol extract of <i>Secamone afzelii</i>

Mbaka, G. O.; Anunobi, C C; Ogunsina, Samson; Osiagwu, Daniel D.

doi:10.1016/j.ejbas.2016.11.003

Cited by 16 publications

(19 citation statements)

References 24 publications

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“…The prostate tissues were harvested and the histology was carried out according to the method already described. 25…”

Section: Prostate Tissue Histologymentioning

confidence: 99%

“…PSA, a glycoprotein found in the serum serves as a quantifiable determinant of prostatic cancer and benign prostatic hyperplasia. 25 The right interpretation of PSA levels to correctly differentiate between benign and malignant prostatic hyperplasia remains unknown. PSA level has been shown to increase in both cases but is more pronounced in prostatic cancer.…”

Section: Effect Of Methanol Leaf Extract Of Duranta Erecta On Serum Pmentioning

confidence: 99%

“…Testosterone is changed to a more powerful androgen; dihydrotestosterone (DHT) by the catalysis of the enzyme type II 5α reductase, which in turn favours the proliferation of prostatic cells (stromal and epithelial cells). , 25,29 Androgens play essential role in BPH pathogenesis. DHT can easily bind to androgen receptors (ARs) due to its higher affinity to the ARs.…”

Section: Effect Of Methanol Leaf Extract Of Duranta Erecta On Serum Tmentioning

confidence: 99%

“…14,15 Many medicinal plants rich in antioxidant property have been shown to be effective in improving oxidative stress in BPH. 25…”

Section: Effect Of Methanol Leaf Extract Of Duranta Erecta On Prostatmentioning

confidence: 99%

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Effect of Methanol Leaf Extract of Duranta erecta in Rats Induced with Benign Prostatic Hyperplasia

2020

TJNPR

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The prostate gland is one of the parts that make up the male reproductive system. It is located at the base of the urinary bladder where it aids in the production of fluid that is alkaline in nature. This fluid helps to protect the sperm. 1 When there is an overgrowth of the prostate gland; it results in Benign Prostatic Hyperplasia (BPH). 2 BPH is one of the most frequent diseases in ageing men. Benign prostatic hyperplasia manifests in 30-40% of men within the age of 40 years, and its prevalence increases linearly to 70-80% in men older than 80 years. 3 BPH disease is depicted by a noncontrollable and rapid increase of the prostate epithelial cells and stromal cells, which results in enlargement of the prostate size. 4 As prostate increases, it narrows the urethra, thus decreasing the rate of urine outflow. The retention of urine in the bladder could lead to lower urinary tract symptoms (LUTS). 5 The disordered physiological processes associated with the disease are still unclear. However, several researchers have proposed that any of the following; oxidative stress, suppression of apoptosis and uncontrollable increase in cell proliferation play vital roles in the initiation and progression of BPH. 6

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“…The prostate tissues were harvested and the histology was carried out according to the method already described. 25…”

Section: Prostate Tissue Histologymentioning

confidence: 99%

Section: Effect Of Methanol Leaf Extract Of Duranta Erecta On Serum Pmentioning

confidence: 99%

Section: Effect Of Methanol Leaf Extract Of Duranta Erecta On Serum Tmentioning

confidence: 99%

“…14,15 Many medicinal plants rich in antioxidant property have been shown to be effective in improving oxidative stress in BPH. 25…”

Section: Effect Of Methanol Leaf Extract Of Duranta Erecta On Prostatmentioning

confidence: 99%

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Effect of Methanol Leaf Extract of Duranta erecta in Rats Induced with Benign Prostatic Hyperplasia

2020

TJNPR

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“…11 Its use in the treatment of benign prostatic hyperplasia (BPH) has also been reported. 12 The phytochemical study of S. afzelii revealed a high concentration of flavonoids, saponins, reducing sugars, coumarins and the triterpenoid friedelin. 13 Because of the wide application of S. afzelii by the traditional healers, it was found necessary to evaluate its toxicity profile.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Histomorphological and Toxicological Changes in Rodents after treatment with Hydroethanolic Extract of the Secamone Afzelii Aerial Parts

Mbaka

Akala

2018

J Morphol Sci

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Objective To evaluate the histomorphological and toxicological changes in rodents after treatment with hydroethanolic extract of the Secamone afzelii aerial parts. Materials and Methods An acute toxicity study on Swiss albino mice of both sexes was performed. Administration of a single dose of 2,000 mg/kg −1 of body weight (bwt) of S. afzelii extract by gavages to 5 mice showed no mortality; hence, a 1/10th dose was used as the highest therapeutic dose. The intra-peritoneal administration produced dose-dependent mortality, with median lethal dose (LD50) being ∼ 281.8 mg/kg −1. In a subacute toxicity study, Wistar rats received daily administration of the extract in the dose range of 50 to 200 mg/kg bwt for 35 days. Its effects on histological, biochemical and hematological parameters were evaluated. Results There was an initial body weight decrease in all the treated animals in the first 7 days. Thereafter, increase in body weight was observed. The treated animals also exhibited organ weight increase when compared with the control. Statistically significant increase (p < 0.05) in aspartate aminotransferase (AST) occurred in the extract treated animals, whereas alanine aminotransferase (ALT) showed a statistically insignificant (p ≥ 0.05) increase when compared with the control. Total plasma protein (TPP) and albumin (ALB) also exhibited insignificant (p ≥ 0.05) increases, while total bilirubin (T. BIL) decreased compared with the control. Insignificant (p ≥ 0.05) changes also occurred in the plasma creatinine and urea levels in the extract treated animals when compared with the control group. The liver tissue histology showed no hepatocellular damage. However, inflammatory changes occurred in the testicular tissue, in which a quantitative decrease in spermatogenic cells was observed due to extensive cellular necrosis, leaving only the basement layer of the seminiferous tubules. Conclusion S. afzelii exhibited a high safety margin, an indication that it is safe for consumption. However, after chronic administration, it caused undesirable effect in the testes that could compromise its fertility function.

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Pharmaco-Chemical Analysis and in Vivo Toxicity Assays of Edible Clays Mined in Nigeria and Consumed Globally

Odimegwu

Nkemehule

Eke

et al. 2021

Clays and clay miner.

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Edible clays are consumed by diverse groups of people, especially of African descent, living in Africa and abroad, in a behavior known as geophagy. The clays are used topically as an emollient and drying agent and internally to control diarrhea. Scientific information concerning the chemical constituents and toxicity of edible clays is scarce. The aims of the present study, therefore, were to ascertain the chemical composition of white edible clays (WEC) and gray edible clays (GEC); to determine their toxicity profiles using analytical chemical methods; to test the acute and sub-acute toxicity of edible clays in their natural form as consumed; and to compare the raw and processed clays, and also to compare the latter to a proprietary drug known as ‘Mist kaolin’ (Moko®) which contains some clay along with other chemicals. Atomic absorption spectroscopy (AAS) and gas chromatography/mass spectrometry (GC/MS) were used to determine the elements present. White female Wistar mice and rats were used for the acute and sub-acute toxicity analyses, respectively. The results from AAS showed the presence of heavy metals and metalloids in both GEC and WEC, and the GC/MS revealed the presence of contaminants such as indomethacin and ethyl benzene, but quantities were below human toxicity levels. Doses of 100–500 mg/kg of either clay type could be harmful to the digestive system, but all of the tests revealed that edible clay is not toxic to humans unless very large amounts (500–1000 mg/kg of body weight) are consumed.

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Histomorphological changes in induced benign prostatic hyperplasia with exogenous testosterone and estradiol in adult male rats treated with aqueous ethanol extract of Secamone afzelii

Abstract: Osiagwu (2017) Histomorphological changes in induced benign prostatic hyperplasia with exogenous testosterone and estradiol in adult male rats treated with aqueous ethanol extract of Secamoneafzelii, Egyptian

Cited by 16 publications

References 24 publications

Effect of Methanol Leaf Extract of Duranta erecta in Rats Induced with Benign Prostatic Hyperplasia

Effect of Methanol Leaf Extract of Duranta erecta in Rats Induced with Benign Prostatic Hyperplasia

Evaluation of the Histomorphological and Toxicological Changes in Rodents after treatment with Hydroethanolic Extract of the Secamone Afzelii Aerial Parts

Pharmaco-Chemical Analysis and in Vivo Toxicity Assays of Edible Clays Mined in Nigeria and Consumed Globally

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