Histomorphometric analysis of extraction sockets augmented with Bio‐Oss Collagen after a 6‐week healing period: A prospective study

Heberer, Susanne; Al-Chawaf, Bassem; Hildebrand, Detlef; Nelson, John J.; Nelson, Katja

doi:10.1111/j.1600-0501.2008.01617.x

Cited by 64 publications

(90 citation statements)

References 23 publications

(45 reference statements)

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“…The histologic results of the non-membrane group indicate that the process of socket healing may be initiated from the apical and lateral regions of the extraction socket walls in agreement with observations from previous studies in which soft tissue closure was not performed [10,36]. The periosteum did not contribute to the formation of new bone matrix in the extraction sockets [10] since the open sockets healed with gradual wound contracture and lateral epithelial overgrowth [6,10,37]. Conversely, the sites that were grafted with β-TCP/Clg + membrane demonstrated a more uniform bone structure both in the apical and in the coronal regions of the sockets.…”

Section: Discussionsupporting

confidence: 89%

“…Cells stained for osteonectin (red arrows) were seen close to the newly mineralized bone (immune staining; magnification, ×40) In contrast to the findings of previous studies which observed healing of larger bone defects, the current study showed that the preserved extraction sockets contained 9.7% and 12.5% residual graft in β-TCP/Clg nonmembrane and β-TCP/Clg + membrane groups, respectively. One reason for such favorable results is the regeneration potential of the intact four-walled alveolar sockets common to both groups in this study [10,23]. Both groups showed the residual particles of graft to be well incorporated into the newly mineralized bone as well as into the bone marrow and marginal osteoid [25].…”

Section: Discussionmentioning

confidence: 73%

“…Therefore, preservation of extraction socket dimensions has been attempted by many investigators immediately following tooth extraction [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation

et al. 2011

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The aim of this study was to investigate the healing of human extraction sockets filled with β-tricalcium phosphate and type I collagen (β-TCP/Clg) cones with or without a barrier membrane. Twenty patients were divided in two groups: (A) β-TCP/Clg non-membrane and (B) β-TCP/Clg + barrier membrane. Clinical examination and biopsies from the grafted sites were collected 9 months later. Bone samples were analyzed using histomorphometry and immunohistochemistry. The horizontal dimension of the alveolar ridge was significantly reduced 9 months after socket preservation in the non-membrane group. There was bone formation with no significant differences between the two groups in the areas occupied by new bone (A = 42.4%; B = 45.3%), marrow (A = 42.7%; B = 35.7%), or residual graft (A = 9.7%; B = 12.5%). Immunohistochemistry revealed osteonectin expression in both groups. Both groups demonstrated sufficient amounts of vital bone and socket morphology to support dental implant placement after the 9-month healing period. A future trial to evaluate the alveolar outcomes at an earlier 6-month time point rather than the 9 months used in this study would be of interest.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 73%

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Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation

et al. 2011

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“…This is based on the observation that shear and compression forces are constantly applied to the grafts in the augmentation sites. For that purpose, collagen-based matrices have been evaluated in preclinical and clinical studies in ridge preservation techniques and are currently under investigation for soft tissue volume augmentation (Jung et al 2004, Heberer et al 2008, Araujo et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Soft tissue volume augmentation by the use of collagen‐based matrices: a volumetric analysis

Thoma

Jung

Schneider

et al. 2010

J Clinic Periodontology

113

136

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Thoma DS, Jung RE, Schneider D, Cochran DL, Ender A, Jones AA, Görlach C, Uebersax L, Graf‐Hausner U, Hämmerle CHF. Soft tissue volume augmentation by the use of collagen‐based matrices: a volumetric analysis. J Clin Peridontol 2010; 37: 659–666. doi: 10.1111/j.1600‐051X.2010.01581.x. Abstract Objectives: The aim was to test whether or not soft tissue augmentation with a newly developed collagen matrix (CM) leads to volume gain in chronic ridge defects similar to those obtained by an autogenous subepithelial connective tissue graft (SCTG). Material and Methods: In six dogs, soft tissue volume augmentation was performed by randomly allocating three treatment modalities to chronic ridge defects (CM, SCTG, sham‐operated control). Impressions were taken before augmentation (baseline), at 28, and 84 days. The obtained casts were optically scanned and the images were digitally analysed. A defined region of interest was measured in all sites and the volume differences between the time points were calculated. Results: The mean volume differences per area between baseline and 28 days amounted to a gain of 1.6 mm (CM; SD±0.9), 1.5 mm (SCTG; ±0.1), and a loss of 0.003 mm (control; ±0.3). At 84 days, the mean volume differences per area to baseline measured a gain of 1.4 mm (CM; ±1.1), 1.4 mm (SCTG; ±0.4), and a loss of 0.3 mm (control; ±0.3). The differences between CM and SCTG were statistically significant compared with control at 28 and 84 days (p<0.001). Conclusion: Within the limits of this animal study, the CM may serve as a replacement for autogenous connective tissue.

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“…. Com relação aos implantes imediatos, a presença de perda óssea marginal ainda representa um desafio para o clínico [37][38][39][40] . Sendo assim, tanto na utilização de técnicas de preservação do rebordo, quanto na instalação de implantes imediatos, inúmeros aspectos devem ser observados, na tentativa de se obter melhor previsibilidade dos resultados.…”

Section: Introductionunclassified

Influência do 'biotipo periodontal' na remodelação dos tecidos moles e da tábua óssea vestibular em alvéolos pós-exodontia e implantes imediatos, com e sem enxerto xenógeno

Maia¹

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Histomorphometric analysis of extraction sockets augmented with Bio‐Oss Collagen after a 6‐week healing period: A prospective study

Cited by 64 publications

References 23 publications

Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation

Beta-tricalcium phosphate/type I collagen cones with or without a barrier membrane in human extraction socket healing: clinical, histologic, histomorphometric, and immunohistochemical evaluation

Soft tissue volume augmentation by the use of collagen‐based matrices: a volumetric analysis

Influência do 'biotipo periodontal' na remodelação dos tecidos moles e da tábua óssea vestibular em alvéolos pós-exodontia e implantes imediatos, com e sem enxerto xenógeno

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