Histomorphometric analysis of inflammatory response and necrosis in re-implanted central incisor of rats treated with low-level laser therapy

Vilela, Rianne Gomes; Gjerde, Kjersti; Frigo, Lúcio; Leal-Junior, Ernesto César Pinto; Lopes-Martins, Rodrigo Álvaro Brandão; Kleine, Brígida Mônica; Prokopowitsch, Igor

doi:10.1007/s10103-011-0937-7

Cited by 21 publications

(33 citation statements)

References 19 publications

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“…The results of this study showed that in the specimens of G1, the inflammatory process and external inflammatory root resorption varied from moderate (30th day) to intense (60th day). These findings corroborate the results of a previous study which demonstrated that the selection of dry storage promotes cell necrosis of the periodontal ligament and cementum contributing to inflammation and resorption.…”

Section: Discussionsupporting

confidence: 92%

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Evaluation of laser phototherapy (λ 780 nm) after dental replantation in rats

Carvalho

Andrade

Barbosa

et al. 2016

Dental Traumatology

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Section: Discussionsupporting

confidence: 92%

“…Recently, laser phototherapy has been investigated as a clinical procedure for use after tooth replantation . Previous studies have shown that laser phototherapy increases local microcirculation , fibroblast proliferation , and collagen synthesis in many healing processes.…”

mentioning

confidence: 99%

Evaluation of laser phototherapy (λ 780 nm) after dental replantation in rats

Carvalho

Andrade

Barbosa

et al. 2016

Dental Traumatology

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show abstract

“…The observed results with the laser group, may be attributed to the modulation of the inflammatory process, which in turn is vital for diminution of the external inflammatory resorption. Vilela et al (39) had shown similar observations, were they found that laser irradiation to the entrance of alveolus and root surface before replantation inhibited the osteoclastic action and enhanced the synthesis of formative cells such as: fibroblasts, cementoblasts, and osteoblasts.…”

Section: Discussionmentioning

confidence: 74%

Root Surface Treatment Using Diode Laser in Tooth Replantation (Experimental Study in Rats)

Hafez

Karam

Ali

2019

Alexandria Dental Journal

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INTRODUCTION: Avulsion of teeth radically affects the integrity of the tooth and the supporting tissue, and impairs the natural dentition as a whole; thus, all efforts must be directed to the replantation of traumatically avulsed teeth. However, its success is limited due to the occurrence of external root resorption. The challenge is to follow an effective protocol that reduces the occurrence of root resorption and allow for reestablishment of the natural architecture of the periodontal tissue. Biomodulation provided by low level laser therapy provides a promising tool in managing the inflammatory process and augmentation of the reparative process. OBJECTIVES: Was to evaluate the effect of low-level laser therapy (LLLT) on the healing process of rat teeth replanted after delayed replantation. MATERIALS AND METHODS: Thirty healthy Albino male rats had their maxillary left incisors extracted; According to the root surface treatment before the replantation, the teeth were assigned randomly to two groups (n = 15): G1 (control)-no root surface treatment; G2 (study group)-laser diode treatment on the root surface. The teeth were replanted into their respective sockets after 30 minutes, mimicking the natural timing it would take to replant an avulsed tooth. G2 were treated with LLLT performed on the buccal and palatal mucosa every 48 hours for 15 days. The rats were sacrificed after 15, 30 and 45 days of replantation. The specimens were processed for histological and histomorphometric analysis to determine the average root resorption areas and to evaluate the histological events. RESULTS: Histomorphometric analysis showed that the study group (Laser irradiated group) showed lower areas of root resorption and ankylosis, than in control group (non-irradiated group); with a significant statistical difference (p > 0.05). Histological assessment showed restoration of periodontal ligament attachment and increased vascularity in the study group. CONCLUSIONS: Laser irradiation reduces external root resorption and ankylosis in delayed tooth replantation.

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“…Currently, radiotherapy is one of the selected treatment methods in early diagnosed cases. [8] Ionizing radiation causes chemical damage in tissues, and radiotherapy may cause chemical changes in microcirculation. There is evidence that radiotherapy creates changes in dental pulp.…”

Section: Discussionmentioning

confidence: 99%

Histopathological changes in dental pulp of rats following radiotherapy

et al. 2017

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Background:Radiotherapy is one of the oral and pharyngeal cancer treatment methods that can cause damage to the tissues in the radiation area; the purpose of this study is to evaluate the effects of radiotherapy on dental pulp tissue in rats.Materials and Methods:In this interventional, experimental double-blind study, 30 rats were studied in three groups (n = 10 each). The first group received 12 gray (Gy), the second group received 18 Gy in one session, and the third group was not exposed to radiation (control group). The 5 μm sections of mandibular molar tooth were prepared and stained with hematoxylin and eosin. Samples were studied under optical microscope to evaluate and score inflammation, necrosis, hyalinization, and vascular congestion. The data were coded and analyzed by statistical tests of χ2 and Fisher's exact tests. The significant level of P = 0.05.Results:In Group 1, necrosis in two cases, inflammation in one case, hyalinization in one case, and vascular congestion in four cases were observed. In Group 2, inflammation in four cases, hyalinization in two cases, and vascular congestion in five cases were observed. In Group 3, inflammation was observed only in one case. In comparison between the groups, no significant differences were observed in inflammation (P > 0.05), necrosis (P > 0.05), and hyalinization (P > 0.05). However, the difference was significant for vascular congestion (P < 0.05).Conclusion:Radiotherapy with doses of 12 and 18 Gy had no significant effect on inflammation, necrosis, and hyalinization in all groups; however, the difference was significant for vascular congestion.

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Histomorphometric analysis of inflammatory response and necrosis in re-implanted central incisor of rats treated with low-level laser therapy

Cited by 21 publications

References 19 publications

Evaluation of laser phototherapy (λ 780 nm) after dental replantation in rats

Evaluation of laser phototherapy (λ 780 nm) after dental replantation in rats

Root Surface Treatment Using Diode Laser in Tooth Replantation (Experimental Study in Rats)

Histopathological changes in dental pulp of rats following radiotherapy

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